Novel Approaches in Stem Cell Research
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (7 April 2022) | Viewed by 3939
Special Issue Editor
Interests: pluripotent stem cells; neurosensory systems; stem cell differentiation; neuroplasticity; neurogenesis; retinal organoids; gene therapy; organ-on-chip
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Besides general shortcomings and ethical problems of animal models with regard to clinical, pharmacological and biological research, broadly used animals such as mice do not represent the human organisms in many regards. Stem cells and their resulting model systems comprise the important 3R-potential to significantly reduce, refine and replace current animal models, and to increase the translatability of results from preclinical to clinical phases to make the entire drug development process much more economic, quicker, and safer. A variety of novel models based on stem cells and their differentiated progeny have appeared just lately. Here, not only organoids and assembloids, but also Organ-on-a-chip (OoaC) Systems were found that combine unique features of cell-assays (human genes) and animal models (complex tissues and blood circulation). Advanced stem cell model systems open up entirely new possibilities in research and therefore should be considered as one of the most promising techniques for current and future approaches.
Prof. Dr. Stefan Liebau
Guest Editor
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Keywords
- pluripotent stem cells
- stem cell differentiation
- models
- organ-on-chip
- assembloids
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