Rab GTPases: From Molecular Mechanism to Pathology

Dear Colleagues,

Rab GTPases are major coordinators of intracellular membrane trafficking, including vesicle transport, membrane fission, tethering, docking and fusion events. Rab GTPases are strictly controlled by two important regulators: the guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) that undergo conformational changes by translocation between the cytosol and membranes. In addition to the molecular mechanisms, studies using knockout mice and genetic analysis of humans have reported that Rab proteins are associated with various neurological diseases, immune diseases, cancer and other pathological conditions.

This Special Issue, “Rab GTPases: From Molecular Mechanism to Pathology”, aims to collect high quality research articles, review articles and communications (including opinion and hypothesis papers) in all fields of Rab GTPases and their regulators, with a focus on molecular and cell biological research. Since the aim of this Special Issue is to illustrate, through selected works, frontier research in Rab GTPases and their regulators, we encourage relevant experts and colleagues to contribute papers reflecting the latest progress in their particular research field. Even papers regarding organelle formation alone and membrane trafficking alone are welcomed.

Prof. Dr. Takayuki Tsukuba
Collection Editor

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