Advanced in Glucose Biosensing

A special issue of Chemosensors (ISSN 2227-9040).

Deadline for manuscript submissions: closed (30 November 2016) | Viewed by 6001

Special Issue Editors


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Guest Editor
Department of Mechanical Engineering, Iowa State University, Ames, IA 50011, USA
Interests: electrochemical sensors and biosensors; nanomaterials; graphene; point-of-care diagnostics; printed biosensors; flexible electronics; quantum dot bioconjugates

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Guest Editor
Department of Agricultural & Biological Engineering, University of Florida, Gainesville FL, 32611, USA
Interests: electrochemical sensors and biosensors; small molecule sensing; nanomaterials; root and seed physiology
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Special Issue Information

Dear Colleagues,

Diabetic mellitus is a metabolic disease marked by high levels of blood glucose that can lead to serious complications including kidney failure, blindness, cardiovascular disease, and premature death. The World Health Organization estimates that the number of people with diabetes is approximately 350 million with projections of 590 million by 2035. In order to prevent diabetic complications, diabetics must contain tight glycemic control by monitoring their glucose levels throughout the day, typically through fingerprick blood glucose biosensors. Fingerprick glucose biosensing is quite arduous to the diabetic patient, requiring hand washing, a finger prick with a lancet, and blood application to a test strip which is often times painful, publicly embarrassing, costly to the patient, and limited to one-time snapshot measurements of blood glucose levels.

This Special Issue is devoted to exploring new advances in glucose biosensing that seek to overcome the drawbacks of conventional fingerprick glucose biosensing. Glucose biosensors that are geared towards obtaining patient blood glucose levels by monitoring other sampling medium, such as tears, saliva, and sweat, in a noninvasive or continuous fashion are particularly encouraged. Studies that use new or nonconventional materials to improve biosensor transduction (e.g., nanomaterials, such as graphene, carbon nanotubes, or metallic nanoparticles) or eliminate the need for biological agents (e.g., non-enzymatic biosensing) are also of interest. Research that changes the paradigm of glucose biosensing by presenting a completely new transduction element such as eye contact lenses that monitor glucose in tears or wearable tattoos/bandages that monitor glucose in sweat or subcutaneous fluid are of high interest. Manuscripts focused on diverse sensing modalities, including optical or electrochemical sensing, as well as those focused on cloud-based data management or the advancement of the Internet of Things with regards to glucose biosensing will also be accepted.

Prof. Dr. Jonathan Claussen
Prof. Dr. Eric McLamore
Guest Editors

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Keywords

  • Glucose
  • Biosensors
  • Nanomaterials
  • Wearable biosensors
  • Noninvasive biosensors
  • Electrochemical biosensors
  • Optical biosensors
  • Enzymes

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Published Papers (1 paper)

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Article
Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose Monitoring
by Mohammed Marie and Omar Manasreh
Chemosensors 2017, 5(1), 4; https://doi.org/10.3390/chemosensors5010004 - 26 Jan 2017
Cited by 3 | Viewed by 5528
Abstract
The influence of the as-grown zinc oxide nanorods (ZnO NRs) on the fabricated electrochemical sensor for in vitro glucose monitoring were investigated. A direct growth of ZnO NRs was performed on the Si/SiO2/Au electrode, using hydrothermal and sol-gel techniques at low [...] Read more.
The influence of the as-grown zinc oxide nanorods (ZnO NRs) on the fabricated electrochemical sensor for in vitro glucose monitoring were investigated. A direct growth of ZnO NRs was performed on the Si/SiO2/Au electrode, using hydrothermal and sol-gel techniques at low temperatures. The structure, consisting of a Si/SiO2/Au/GOx/Nafion membrane, was considered as a baseline, and it was tested under several applied potential 0.1–0.8 V. The immobilized working electrode, with GOx and a nafion membrane, was characterized amperometrically using a source meter Keithely 2410, and an electrochemical impedance Gamry potentiostat. The sensor exhibited the following: a high sensitivity of ~0.468 mA/cm2 mM, a low detection limit in the order of 166.6 µM, and a fast and sharp response time of around 2 s. The highest sensitivity and the lowest limit of detection were obtained at 0.4 volt, after the growth of ZnO NRs. The highest net sensitivity was obtained after subtracting the sensitivity of the baseline, and it was in the order of 0.315 mA/cm2·mM. The device was tested with a range of glucose concentrations from 1–10 mM, showing a linear line from 3–8 mM, and the device was saturated after exceeding high concentrations of glucose. Such devices can be used for in vitro glucose monitoring, since glucose changes can be accurately detected. Full article
(This article belongs to the Special Issue Advanced in Glucose Biosensing)
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