Nucleic Acid Probes
A special issue of Chemosensors (ISSN 2227-9040).
Deadline for manuscript submissions: closed (31 August 2014) | Viewed by 27781
Special Issue Editor
Special Issue Information
Dear Colleagues,
Revolutionary advances in genome sequencing and nucleic acid biology over the past 15 years have resulted in an explosion of data and knowledge about the identity, function and regulation of cellular DNA and RNA. This insight is increasingly harnessed for applications in molecular biology, biotechnology, and medicine. In parallel with these advances, there has been a growing need for techniques that enable detection of nucleic acids. Cleverly designed probes and assays are already used to localize RNA expression in living cells, perform advanced karyotyping, detect disease-related single nucleotide polymorphisms (SNPs), monitor enzyme activity, detect biological threat agents, and monitor PCR in real-time, to name only but a few important examples.
In this special issue of Chemosensors, we welcome communications, full papers and focused reviews on topics that pertain to the use of reporter-modified oligonucleotides and analogues thereof for the detection of nucleic acids and other biomolecules. This includes - but is not limited to - development and characterization of novel reporter-modified oligonucleotides/PNA/polyamides, aptasensors, assays and biosensors. Emphasis should be on chemistry/technology development and proof-of-concept studies, rather than adaptation of a well-established probes/assays/sensors to a new biological target. Please join us in collecting some of the best work in this exciting area from laboratories worldwide.
Dr. Patrick J. Hrdlicka
Guest Editor
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Keywords
- DNA/RNA/triplex/quadruplex/i-DNA/Z-DNA/H-DNA detection
- detection via fluorescence, electrochemistry or EPR spectroscopy
- hybridization probes
- SNP-discriminating probes
- base-discriminating fluorescent nucleotides
- intrinsically fluorescent probes
- detection of abasic sites or insertion/deletion mutations
- elucidation of protein function
- aptasensors
- molecular beacons
- dual probes
- FRET wires
- biosensors
- fluorescence in situ hybridization
- tricomponent reactions
- QUAL; ECHO; LNA; PNA; polyamides; TALEN; CRISPR
- zinc fingers
- Invaders
- gold nanoparticles
- nanomaterials
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