Advances in Pediatric Multisystem Inflammatory Syndrome
A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Allergy and Immunology".
Deadline for manuscript submissions: closed (15 January 2024) | Viewed by 4536
Special Issue Editor
Special Issue Information
Dear Colleagues,
At first, after reviewing the reports coming out of China in early 2020, it seemed that hyperinflammation was one of the primary reasons for the high mortality rate of severe COVID-19 disease. The first prediction of its immunopathology came not by chance but from pediatric rheumatologists with great expertise in treating multisystem inflammatory syndromes (MIS). Dreaded representatives of these syndromes, hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS), are potentially life-threatening conditions. The latter can occur in children with certain autoimmune disorders. In the last decade, pediatric rheumatology and the understanding of autoinflammation and diseases related to innate immunity have progressed dramatically. Autoinflammatory diseases are commonly associated with symptoms of hyperinflammation, while the presence of autoinflammation is often linked to causes of hyperinflammatory syndromes. Although we are certain that in severe COVID-19, we face a localized cytokine "flooding" instead of a systemic “storm,” more attention than ever before is being directed to multisystemic inflammatory syndromes.
In April 2020, United Kingdom health officials reported the first cases of what would become known as multisystem inflammatory syndrome in children (MIS-C). The children affected had various symptoms that emerged suddenly and then progressed rapidly. As word of the syndrome spread worldwide, more cases began to be reported, prompting widespread interest among pediatricians.
The latest immunological research has been translated into everyday clinical practice at lightning speed. This is, on the one hand, a fantastic achievement of medicine. On the other, general pediatricians are struggling to keep up with the many newly introduced concepts. This situation has been further complicated because clinicians, immunologists, and biologists often use overlapping but slightly different terminology.
This Special Issue aims to help readers understand the various terms for inflammation, including hyperinflammation, multisystem inflammatory syndrome, autoimmunity, and autoinflammation.
The Special Issue is currently soliciting papers that present the latest scientific results in a practical manner. We are looking for articles that not only describe the findings of scientific studies but also provide insight into how these findings can be applied in everyday life. We believe that this type of translation is essential for making scientific progress accessible to a broader audience. In addition, we feel that this approach will help to promote public understanding and support for scientific research. We encourage scientists from all disciplines to submit their work for consideration.
Dr. Tamás Constantin
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- multisystem inflammatory syndromes
- hyperinflammation
- multisystem inflammatory syndrome in children
- autoimmunity
- autoinflammation
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.