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Children, Volume 12, Issue 8

August 2025 - 145 articles

Cover Story: We examined a 12-week exercise program focusing on rhythm, balance, and coordination in ASD (n = 15) or ADHD (n = 12), ages 6–12. Primitive reflexes, fine motor skills, and social–behavioral functioning (SRS-2 for ASD, Conners-3 for ADHD) were assessed before and after. In ASD, left-side asymmetrical tonic neck reflex retention decreased (= 0.012), and right-hand fine motor skills improved (p = 0.023). ADHD showed similar motor gains (p = 0.007) and lower Conners-3 total score and global index (p = 0.016, p = 0.020). ASD had a non-significant trend to lower SRS-2 total score. Findings suggest that rhythm-, balance-, and coordination-focused exercise may integrate certain primitive reflexes and improve fine motor and social–behavioral skills, with practical value for clinical and educational settings. View this paper
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Articles (145)

  • Article
  • Open Access
1,257 Views
11 Pages

Parapneumonic Effusion Versus Pulmonary Empyema in Children: Analysis of Risk Factors and Laboratory Predictors Through a Single Center Experience

  • Marta Improta,
  • Francesca Morlino,
  • Roberta Ragucci,
  • Carolina D’Anna,
  • Stefania Muzzica,
  • Vincenzo Tipo,
  • Antonietta Giannattasio and
  • Marco Maglione

21 August 2025

Background: Parapneumonic effusion is a common complication of community-acquired pneumonia and can range from a simple inflammatory transudate to an organized purulent collection, known as empyema. Progression to empyema significantly worsens the pr...

  • Article
  • Open Access
685 Views
14 Pages

Clinical and Molecular Characterizations of Mitochondrial Disorders: A Tertiary-Care Center Experience

  • Mohammed Almuqbil,
  • Najla Binsabbar,
  • Shahad Alsaif,
  • Sulaiman Almasoud,
  • Talah Albasry,
  • Duaa Baarmah,
  • Waleed Altwaijri and
  • Ahmed Alrumayyan

21 August 2025

Background: Given the limited research on mitochondrial diseases in our area, specifically regarding their genetic variability and diverse clinical manifestations, and considering the significant number of consanguineous marriages in our region, we a...

  • Article
  • Open Access
570 Views
18 Pages

21 August 2025

Background: Thrombospondin-1 (TSP-1) is a matricellular protein involved in kidney fibrosis, potentially influencing the progression of proteinuria. However, its potential as a predictive biomarker for proteinuria events in children with chronic kidn...

  • Article
  • Open Access
573 Views
18 Pages

Parental Knowledge, Attitude and Practices Toward Cariogenic Potential of Pediatric Oral Medications

  • Reham M. Al-Amoudi,
  • Heba Mohamed Elkhodary,
  • Shahad N. Abudawood,
  • Azza El-Housseiny and
  • Osama M. Felemban

21 August 2025

Background/Objectives: Sugar added to pediatric oral medications may increase the risk of dental caries and erosion. Parental awareness and practices play a crucial role in minimizing the oral health risks associated with such medications. Therefore,...

  • Article
  • Open Access
1,932 Views
14 Pages

A 10-Year Review of the Efficacy of Cranial Remolding Orthosis Treatment and Factors That Influence Outcomes for Infants with Isolated Deformational Plagiocephaly

  • Anna L. Trebilcock,
  • Jill L. Findley,
  • J. Suzanne Cherry,
  • Jeffrey A. Kasparek,
  • Melody M. Gordon,
  • Stephen P. Beals and
  • Timothy R. Littlefield

21 August 2025

Background/objectives: The purpose of this study was to examine the overall efficacy and treatment outcomes of CROs in the treatment of isolated deformational plagiocephaly and investigate the variables that influence treatment efficacy. Methods: Thi...

  • Article
  • Open Access
893 Views
32 Pages

21 August 2025

Background/Objectives: Anxiety is a hallmark feature of Williams syndrome (WS), with very high prevalence rates of generalised anxiety disorder (GAD) and specific phobias in both school-aged children and adults, yet a relatively lower prevalence of s...

  • Article
  • Open Access
640 Views
12 Pages

Effect of Midazolam Premedication on Salivary Cortisol Levels in Pediatric Patients with Negative Frankl Behavior: A Pilot Study

  • Juan Ignacio Aura-Tormos,
  • Laura Marqués-Martínez,
  • Esther Garcia-Miralles,
  • Isabel Torres-Cuevas,
  • Bianca Quartararo and
  • Clara Guinot-Barona

20 August 2025

Background/Objectives: This pilot study aimed to evaluate stress levels in pediatric patients classified as definitely negative according to the Frankl scale by measuring salivary cortisol concentrations. Additionally, the study assessed the impact o...

  • Systematic Review
  • Open Access
1,569 Views
23 Pages

Perinatal and Childhood Risk Factors of Adverse Early Childhood Developmental Outcomes: A Systematic Review Using a Socioecological Model

  • Kendalem Asmare Atalell,
  • Gavin Pereira,
  • Bereket Duko,
  • Sylvester Dodzi Nyadanu and
  • Gizachew A. Tessema

20 August 2025

Background: Adverse early childhood developmental outcomes across physical, cognitive, language, communication, and socioemotional domains are major global health concerns. This systematic review aimed to synthesise perinatal and childhood risk facto...

  • Systematic Review
  • Open Access
814 Views
21 Pages

Parental Psychological Response to Prenatal Congenital Heart Defect Diagnosis

  • Cristina Tecar,
  • Lacramioara Eliza Chiperi and
  • Dafin Fior Muresanu

20 August 2025

Background: This systematic review aims to summarize the most recent data from the literature on the psychological aspects of parents of children prenatally diagnosed with congenital heart defects (CHDs). Methods: A comprehensive literature search wa...

  • Article
  • Open Access
1,183 Views
18 Pages

Competitive Anxiety, Sports Injury, and Playing Category in Youth Soccer Players

  • Rafael Sánchez-Ruiz,
  • Laura Gil-Caselles,
  • Alejo García-Naveira,
  • Félix Arbinaga,
  • Roberto Ruiz-Barquín and
  • Aurelio Olmedilla-Zafra

20 August 2025

Background: Adolescence is a critical period of physical, psychological, and social development, during which athletes are particularly vulnerable to stress and injuries. Competitive anxiety has been identified as a psychological factor that may incr...

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Children - ISSN 2227-9067Creative Common CC BY license