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Children
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Current Research on Cleft Lip in Children
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Current Research on Cleft Lip in Children

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Dentistry".

Deadline for manuscript submissions: closed (25 July 2022) | Viewed by 17813

Special Issue Editors

Prof. Dr. Thais Marchini Oliveira

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Guest Editor
Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry and Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, SP, Brazil
Interests: children with oral clefts and the relation to the rehabilitative progress of children; in terms of medicine; speech; dentistry; physiology; psychology
Special Issues, Collections and Topics in MDPI journals
Dr. Eloá Cristina Passucci Ambrósio

E-Mail Website
Co-Guest Editor
Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry and Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, SP, Brazil
Interests: pediatric dentistry; anomalies craniofacial; cleft lip; cleft palate; 3D image
Special Issues, Collections and Topics in MDPI journals
Dr. Paula Karine Jorge

E-Mail Website
Co-Guest Editor
Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry and Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, SP, Brazil
Interests: pediatric dentistry; cleft lip and palate; proteome
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Maria Aparecida Andrade Moreira Machado

E-Mail Website
Co-Guest Editor
Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry and Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, SP, Brazil
Interests: pediatric dentistry
Special Issues, Collections and Topics in MDPI journals
Dr. Cleide Felício Carvalho Carrara

E-Mail Website
Co-Guest Editor
Department of Pediatric Dentistry, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, SP, Brazil
Interests: cleft lip and palate; pediatric dentistry; tooth eruption and orthodontics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will include papers about all aspects of oral clefts in children in order to expand the evaluation and management of experimental and theoretical results about quality of life, growth and development, speech disorders, epidemiological, genetic and environmental factors linked with oral clefts, and to increase the understanding of fundamental principles and biological questions of oral clefts.

Aims

This Special Issue, titled Current Research on Cleft Lip in Children, will be published in Children (ISSN 2227-9067), an international open-access journal dedicated to a streamlined yet scientifically rigorous dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries.

The Issue focuses on sharing clinical, epidemiological and translational science relevant to children with oral clefs. Moreover, the primary goals of the Special Issue are to highlight knowledge about all aspects about children with oral cleft, such as epidemiological and clinical challenges, etiology, speech disorders, quality of life, growth and development, and related anomalies in order to help rehabilitate and reinsert patients in society. In addition to original research, the Issue will publish expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in children with oral clefs. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits the rapid open-access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.

Scope

Topics of interest include, but are not limited to:

  • Public Health and Epidemiology;
  • Growth and Development
    • Maxilla;
    • Dental cast;
    • Three-dimensional imaging;
    • Facial profile;
    • Relationship maxilla and mandible;
  • Pediatric Subspecialties
    • Neurology;
    • Developmental/behavioral medicine;
    • Neonatal/perinatal medicine;
    • Plastic surgery;
    • Systemic disorders;
  • Quality of life
    • Family relationship;
    • Society;
    • Patients with oral clefts;
    • Psychological aspects;
  • Speech disorders;
  • Etiology
    • Genetics;
    • Environment;
  • Epidemiology
    • General aspects.

Prof. Dr. Thais Marchini Oliveira
Dr. Eloá Cristina Passucci Ambrósio
Prof. Dr. Paula Karine Jorge
Prof. Dr. Maria Aparecida Andrade Moreira Machado
Dr. Cleide Felício Carvalho Carrara
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral cleft
  • cleft lip and palate
  • growth and development
  • speech disorders
  • quality of life
  • etiology
  • genetic and environmental factors

Published Papers (6 papers)

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Editorial

Jump to: Research

3 pages, 184 KiB  
Editorial
Research on Cleft Lip and Palate: What Is New?
by Eloá Cristina Passucci Ambrosio, Paula Karine Jorge, Cleide Felício Carvalho Carrara, Maria Aparecida Andrade Moreira Machado and Thais Marchini Oliveira
Children 2024, 11(1), 25; https://doi.org/10.3390/children11010025 - 25 Dec 2023
Viewed by 1362
Abstract
Craniofacial development begins during the fourth week of intrauterine life (IUL) [...] Full article
(This article belongs to the Special Issue Current Research on Cleft Lip in Children)

Research

Jump to: Editorial

12 pages, 3514 KiB  
Article
A Point-of-Care Digital Workflow for 3D Printed Passive Presurgical Orthopedic Plates in Cleft Care
by Parichehr Zarean, Paridokht Zarean, Florian M. Thieringer, Andreas A. Mueller, Sabine Kressmann, Martin Erismann, Neha Sharma and Benito K. Benitez
Children 2022, 9(8), 1261; https://doi.org/10.3390/children9081261 - 20 Aug 2022
Cited by 8 | Viewed by 5401
Abstract
Cleft lip and palate are one of the most common congenital craniofacial malformations. As an initial treatment, presurgical orthopedics is considered standard treatment at many cleft centers. Digital impressions are becoming feasible in cleft care. Computer-aided design (CAD) and three-dimensional (3D) printing are [...] Read more.
Cleft lip and palate are one of the most common congenital craniofacial malformations. As an initial treatment, presurgical orthopedics is considered standard treatment at many cleft centers. Digital impressions are becoming feasible in cleft care. Computer-aided design (CAD) and three-dimensional (3D) printing are manufacturing standards in dentistry. The assimilation of these technologies has the potential to alter the traditional workflow for the fabrication of customized presurgical orthopedic plates. We present a digital workflow comprising three steps: 3D digital image acquisition with an intraoral scanner, open-source CAD modeling, and point-of-care 3D printing for the fabrication of personalized passive presurgical plates for newborns with cleft lip and palate. The digital workflow resulted in patient-related benefits, such as no risk of airway obstruction with quicker data acquisition (range 1–2.5 min). Throughput time was higher in the digital workflow 260–350 min compared to 135 min in the conventional workflow. The manual and personal intervention time was reduced from 135 min to 60 min. We show a clinically useful digital workflow for presurgical plates in cleft treatment. Once care providers overcome procurement costs, digital impressions, and point-of-care 3D printing will simplify these workflows and have the potential to become standard for cleft care. Full article
(This article belongs to the Special Issue Current Research on Cleft Lip in Children)
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13 pages, 1546 KiB  
Article
Craniofacial Growth at Age 6–11 Years after One-Stage Cleft Lip and Palate Repair: A Retrospective Comparative Study with Historical Controls
by Benito K. Benitez, Seraina K. Weibel, Florian S. Halbeisen, Yoriko Lill, Prasad Nalabothu, Ana Tache and Andreas A. Mueller
Children 2022, 9(8), 1228; https://doi.org/10.3390/children9081228 - 13 Aug 2022
Cited by 2 | Viewed by 1633
Abstract
Background: Primary alveolar bone grafting inhibits craniofacial growth. However, its effect on craniofacial growth in one-stage cleft lip and palate protocols is unknown. This study investigated whether primary alveolar bone grafting performed during one-stage unilateral cleft lip and palate repair negatively affects growth [...] Read more.
Background: Primary alveolar bone grafting inhibits craniofacial growth. However, its effect on craniofacial growth in one-stage cleft lip and palate protocols is unknown. This study investigated whether primary alveolar bone grafting performed during one-stage unilateral cleft lip and palate repair negatively affects growth up to 6–11 years old. Methods: The craniofacial growth, dental arch relationship and palatal morphology at 6–11 years old in children with unilateral cleft lip and palate were compared retrospectively. Two cohorts after a one-stage protocol without (Group A) and with (Group B) primary bone grafting at the same center were compared. Further, cephalometric measurements for growth were compared with an external cohort of a one-stage protocol and a heathy control. Results: Group A comprised 16 patients assessed at 6.8 years (SD 0.83), and Group B comprised 15 patients assessed at 9 years (SD 2.0). Cephalometric measurements indicated similar sagittal maxillary growth deficits and a significant deviation in maxillary inclination in both groups compared to the healthy group. Moderate to severe changes in palatal morphology were observed in 70% of the members in both groups. Conclusion: Omitting primary alveolar bone grafting under the one-stage protocol with two-flap palatoplasty studied did not improve growth at 6–11 years. The results implicate two-flap palatoplasty with secondary healing as having greater adverse effects on growth than primary alveolar bone grafting. Dental and palatal morphology was considerably compromised regardless of primary alveolar bone grafting. Full article
(This article belongs to the Special Issue Current Research on Cleft Lip in Children)
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9 pages, 259 KiB  
Article
Oral-Health-Related Quality of Life among Non-Syndromic School-Age Children with Orofacial Clefts: Results from a Cross-Sectional Study in Northern Italy
by Patrizia Defabianis, Cesare Cogo, Stefania Massa and Federica Romano
Children 2022, 9(7), 1098; https://doi.org/10.3390/children9071098 - 21 Jul 2022
Cited by 7 | Viewed by 1614
Abstract
The aim of this cross-sectional study was to determine the influence of orofacial clefts on the oral-health-related quality of life (OHRQoL) in a group of Italian children and adolescents and to examine whether gender, age, cleft type, and surgical protocol were associated with [...] Read more.
The aim of this cross-sectional study was to determine the influence of orofacial clefts on the oral-health-related quality of life (OHRQoL) in a group of Italian children and adolescents and to examine whether gender, age, cleft type, and surgical protocol were associated with patients’ OHRQoL. A total of 71 patients with cleft lip and/or cleft palate (CLP) and 71 age- and gender-matched controls (aged 8 to 18 years) were asked to complete the Child Oral Health Impact Profile (COHIP), a validated and reliable questionnaire to assess self-reported OHRQoL in children and teenagers. Children with orofacial clefts showed statistically significant lower quality of life scores than controls for total OHRQoL and for each of the subscales. Gender, the type of cleft, and the type of surgical protocol had no significant influence on OHRQoL. The negative impact of CLP on the area of self-image was greater in 12–18-year-olds, indicating a higher need for psychosocial counselling. These findings suggest that Italian CLP children and adolescents experience a poorer OHRQoL in comparison to their non-cleft peers. Full article
(This article belongs to the Special Issue Current Research on Cleft Lip in Children)
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11 pages, 485 KiB  
Article
The Perception and Experience of Parents of Children with Cleft Lip and Palate Concerning the Use Pre-Surgical Infant Orthopedics: A Questionnaire-Based Cross-Sectional Survey
by Shaymaa Hadi Albustani, Arkadiusz Dziedzic and Mushriq Abid
Children 2022, 9(7), 1054; https://doi.org/10.3390/children9071054 - 15 Jul 2022
Cited by 6 | Viewed by 3497
Abstract
Background: A transitory period prior to the surgical correction of cleft lip and palate (CLP) is associated with adverse impacts, which may require a medical intervention. Pre-surgical infant orthopedics (PSIO) is deemed to reduce the functional and psychological burden, offering a transition until [...] Read more.
Background: A transitory period prior to the surgical correction of cleft lip and palate (CLP) is associated with adverse impacts, which may require a medical intervention. Pre-surgical infant orthopedics (PSIO) is deemed to reduce the functional and psychological burden, offering a transition until the definite surgical intervention. Aim: To assess the attitude of Iraqi mothers concerning the application and management of pre-surgical orthopedic appliances in children with cleft lip and palate, taking consideration of the mothers’ occupational status. Methods: The cross-sectional study was conducted in the College of Dentistry at Baghdad University from 5 January 2020 to 4 December 2021. A questionnaire form was validated based on existing data related to the assessment of parents’ satisfaction concerning PSIO. Results: A concern related to the impression procedure was reported by a minority of the participants (6.8%) and it was associated mainly to the perceptions of housewives’ vs. working mothers (p < 0.05). The perceived infants’ discomfort during the impression procedure reported at 11.9% was significantly associated with housewives’ status (p < 0.05). In general, the vast majority of respondents considered the impression as being non-invasive (96.6%). Most mothers found no difficulties in following the instructions of the specialist regarding the insertion of the PSIO and/or taping the elastic bands (62.7%). Respondents believed that CLP infants routinely require PSIO treatment. Interestingly, only a minority of mothers performed an Internet search to look for information about PSIO (7%). The majority indicated the PSIO treatment as beneficial for their infant and a substantial proportion of respondents were satisfied with the outcomes of PSIO, encouraging other parents to consent the PSIO treatment. Conclusion: In general, mothers broadly acknowledged the primary concept of PSIO and accepted the proposed treatment, with a positive attitude towards pre-surgical CLP management, regardless their socio-economic status. They seemed to understand well the expected benefits of PSIO, including feeding improvement, normalization of speech, and optimization of future surgical outcomes. Full article
(This article belongs to the Special Issue Current Research on Cleft Lip in Children)
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17 pages, 5681 KiB  
Article
Multiple Skeletal Anomalies of Sprague Dawley Rats following Prenatal Exposure to Anastatica hierochuntica, as Delineated by a Modified Double-Staining Method
by Siti Rosmani Md Zin, Mohammed Abdullah Alshawsh and Zahurin Mohamed
Children 2022, 9(5), 763; https://doi.org/10.3390/children9050763 - 23 May 2022
Cited by 4 | Viewed by 2527
Abstract
Anastatica hierochuntica (A. hierochuntica) is a plant that originates from Middle Eastern countries. This herb is commonly consumed by pregnant women to ease the process of childbirth. However, consumption of A. hierochuntica during the prenatal period may disrupt foetal development. In [...] Read more.
Anastatica hierochuntica (A. hierochuntica) is a plant that originates from Middle Eastern countries. This herb is commonly consumed by pregnant women to ease the process of childbirth. However, consumption of A. hierochuntica during the prenatal period may disrupt foetal development. In this study, we aimed to evaluate the potential effects of four different doses (0, 250, 500 and 1000 mg/kg) of A. hierochuntica aqueous extract (AHAE) on the skeletal development of Sprague Dawley rat foetuses. The AHAE was administered from gestational day (GD) 6 till GD20. We also aimed to produce a simplified and reproducible skeletal staining procedure for proper skeletal assessment of full-term Sprague Dawley rat foetuses. Skeletal structures were stained using a modified method that utilised Alcian Blue 8GX and Alizarin Red S dyes. The staining procedure involved fixation, skinning, evisceration, cartilage staining, bone staining and clearing. Our modified staining technique has successfully showed a clear demarcation between the bone and cartilage components, which enabled objective assessment of the skeletal ossification following administration of AHAE. Some skeletal anomalies such as sacrocaudal agenesis and maxillary defect (cleft lip) were observed in 250 and 1000 mg/kg groups, respectively. These findings indicate potential toxicity effects of AHAE on the developing foetuses. Full article
(This article belongs to the Special Issue Current Research on Cleft Lip in Children)
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