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Children
Special Issues
Prenatal Diagnosis—Postnatal Implications
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Prenatal Diagnosis—Postnatal Implications

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Neonatology".

Deadline for manuscript submissions: closed (25 July 2024) | Viewed by 772

Special Issue Editors

Dr. Nicolae Sebastian Ionescu

E-Mail Website
Guest Editor
Pediatric Surgery Department, ‘M.S. Curie’ Emergency Clinical Hospital for Children, 041451 Bucharest, Romania
Interests: endoscopic surgery; prenatal diagnostics and counselling; pulmonary malformation; short bowel; bacterial translocation
Dr. Jurgen Schleef

E-Mail Website
Guest Editor
Department of Pediatric Surgery and Urology, Institute of Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy
Interests: endoscopic surgery; prenatal diagnostics and counselling; pulmonary malformation; short bowel; bacterial translocation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, significant progress has been made in the field of morphological ultrasound, and thus the prenatal diagnosis for most congenital anomalies is more accurate. Earlier diagnosis offers physicians important information about the prenatal evolution of the pathology, representing the history of the described anomaly.

Corroborating the prenatal investigations with postnatal assessment, we are able to guide therapeutic strategy, taking into account not only the current condition but also the complete evolution of the pathology.

This Special Issue, titled “Prenatal Diagnosis—Postnatal Implications”, aims to highlight the significance of prenatal diagnosis in the management of congenital anomalies, considering multiple therapeutic approaches, such as fetal surgery, non-operative management, and surgical management.

We invite authors to contribute to this Special Issue with original articles and comprehensive review articles.

We will be glad to welcome any well-documented contribution.

Dr. Nicolae Sebastian Ionescu
Dr. Jurgen Schleef
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prenatal diagnosis
  • congenital anomalies
  • newborn surgery
  • conservative treatment
  • minimally invasive surgery
  • foetal surgery
  • ethics of congenital malformations approach
  • predictive factors

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Published Papers (1 paper)

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11 pages, 11221 KiB  
Case Report
Minimally Invasive Fetoscopic Resection of Life-Threatening Amniotic Band Constrictions in a Human Fetus at 22 + 2 Weeks of Gestation Complicated by Subtotal Chorioamniotic Separation and Partial Placental Abruption
by Nadja Riehle, Oliver Nowak, Leila Messroghli, Samantha Wakerlin, Thomas Schaible and Thomas Kohl
Children 2025, 12(1), 20; https://doi.org/10.3390/children12010020 - 26 Dec 2024
Viewed by 446
Abstract
Amniotic band syndrome is a constrictive phenomenon in fetal development that can provoke limb autoamputation, malformation, trunk division, and umbilical cord strangulation. The latter two complications will ultimately lead to fetal demise if left untreated. If detected early enough, select cases may benefit [...] Read more.
Amniotic band syndrome is a constrictive phenomenon in fetal development that can provoke limb autoamputation, malformation, trunk division, and umbilical cord strangulation. The latter two complications will ultimately lead to fetal demise if left untreated. If detected early enough, select cases may benefit from prenatal resection of the amniotic bands, thus preventing amputation and fetal death. Yet, especially in the presence of complete chorioamniotic separation, these procedures are rare, technically difficult, and not without significant risk. Objectives: The purpose of this report is to present the surgical technique and outcome of a challenging percutaneous fetoscopic intervention in a human fetus with amniotic band constrictions of a fetal thigh, retroplacental hematoma, partial placental abruption, subtotal chorioamniotic separation, and multiple amniotic bands encircling the umbilical cord. Methods: Minimally invasive, fetoscopic surgery to salvage the fetal life and lower leg was performed at 22 + 2 weeks of gestation under general maternofetal anesthesia. Results: Total resection of all amniotic bands was achieved, notwithstanding the aforementioned challenges. No surgical complications were observed. Despite preterm delivery at 25 + 4 weeks of gestation, the postnatal experience for the infant was favorable and uncomplicated as it furthermore benefitted from neonatal intensive care. At almost three years of age, the child remains healthy and demonstrates normal function of the formerly constricted leg. Conclusions: Our case shows that the combination of tested percutaneous fetoscopic techniques, high-risk obstetrics, and modern neonatology can overcome multiple obstacles in order to save a fetal patient stuck in a near-hopeless situation. Full article
(This article belongs to the Special Issue Prenatal Diagnosis—Postnatal Implications)
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