Omics Technologies and Genomic Studies Unraveling Alzheimer’s Disease Heterogeneity
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Bioinformatics and Systems Biology".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 79
Special Issue Editor
Interests: Alzheimer's association; bioinformatics; genetics; genomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alzheimer’s disease (AD) is a heterogeneous and complex phenotype. Both environmental and genetic factors significantly influence AD. The variability in risk and resilience factors, alongside the differences in neuropathological phenotypes associated with AD, complicates both diagnosis and treatment. Ongoing research aims to elucidate the biological diversity of AD through multi-omics approaches in both peripheral and brain tissues, including single-cell analyses, biomarkers, endophenotypes, imaging, etc. Over 70 genetic loci and various biomarkers have been linked to AD, indicating that multiple pathways may contribute to this disease. Additionally, it is important to note that some individuals exhibit AD pathology without displaying any symptoms. Addressing the heterogeneity of AD is crucial for accurate diagnosis, prevention, treatment, and prediction of disease progression. We invite submissions that explore the heterogeneity of AD, including studies conducted within diverse populations that report novel discoveries or evaluate existing AD markers in new populations. Furthermore, literature reviews and bioinformatics publications that propose innovative methodologies for studying disease heterogeneity are also encouraged.
Dr. Perry G. Ridge
Guest Editor
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Keywords
- Alzheimer
- multi-omics approaches
- heterogeneity
- genetic loci and biomarkers
- neurodegenerative disease research
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