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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Protein Domains: Structure and Molecular Function

edited by Guangfeng Zhou

submission deadline 10 Nov 2025 | 4 articles | Viewed by 11809

Keywords: protein structure; protein domains; domain classification; protein engineering; protein design; protein modeling; machine learning; deep learning; protein structure prediction; protein function prediction

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Neuropituitary Hormones in Metabolic Disorders

edited by

Claudia Camerino

submission deadline 10 Nov 2025 | Viewed by 162

Keywords: oxytocin; vasopressin; thermoregulation; obesity; Prader– Willi syndrome; autism spectrum disorder; anorexia nervosa; craniopharyngioma; metabolic disorders; hypothalamic pituitary disorders; oxytocin-deficiency; vasopressin-deficiency

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Modulation of Oxidative Stress: A Global Perspective for Climate Change Adaptation

edited by

Tihomir Kovač

and

Tihana Marček

submission deadline 15 Nov 2025 | Viewed by 272 | Submission Open

Keywords: oxidative stress; modulation; climate change; environmental factors; adaption

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Biology in Dentistry: Innovations in Diagnosis, Treatment, and Biomaterials

edited by

Maria Maddalena Marrapodi

and Valentina Belli

submission deadline 20 Nov 2025 | 2 articles | Viewed by 5772 | Submission Open

Keywords: oral microbiome; tissue regeneration; biomimetic materials

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Research on Virus-Induced Cellular and Molecular Responses

edited by

Rudian Zhang

submission deadline 30 Nov 2025 | 6 articles | Viewed by 14566 | Submission Open

Keywords: virus infectivity; infectious diseases; cellular stress; autophagy

(This special issue belongs to the Section Molecular Microbiology)

Natural Product in Skin Inflammation and Barrier Function Damage

edited by

Hsiu-Mei Chiang

submission deadline 30 Nov 2025 | 3 articles | Viewed by 9183 | Submission Open

Keywords: skin inflammation; barrier function damage; natural compounds; antioxidant properties; antiaging

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Radiation Oncology

edited by Allen Chen

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6348 | Submission Open

Keywords: molecular and cellular radiobiology; radiation physics; DNA damage and repair; radiation response; cancers

(This special issue belongs to the Section Molecular Medicine)

Cardiovascular Disease: From Molecular Mechanisms to Therapeutic Innovations

edited by Andrea Marzullo

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5373 | Submission Open

Keywords: cardiovascular pathophysiology; molecular biomarkers; inflammation and oxidative stress; therapeutic targets; lipid metabolism

(This special issue belongs to the Section Molecular Medicine)

Omics Analysis for Personalized Medicine

edited by

Golder N. Wilson

and

Tadeja Kuret

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5095 | Submission Open

Keywords: genomics; epigenomics; transcriptomics; proteomics; metabolomics; multi-omics; high throughput; personalized medicine; immune-mediated inflammatory diseases

(This special issue belongs to the Section Molecular Medicine)

Tumor Immunology: From Molecular Mechanisms to Treatment

edited by

Deepika Awasthi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3256 | Submission Open

Keywords: cellular metabolism; metabolic reprogramming; immunometabolism; tumor microenvironment; immunotherapy; metabolites; immunosuppression; immune cells; tumor cells

(This special issue belongs to the Section Molecular Medicine)

Molecular Keys to Bioactivity: Pharmacophore and SAR Exploration in Organic Compounds

edited by

Claudiu N. Lungu

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2529 | Submission Open

Keywords: structure– activity relationship; pharmacophore; chirality; bioactive molecules; morphogenesis; protein targets; membrane interaction; natural products; synthetic organic compounds; drug discovery

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Natural Phytochemicals as Modulators of Cellular Pathways and Therapeutic Targets in Disease Models

edited by

Jui-Hung Yen

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2278 | Submission Open

Keywords: phytochemicals; cellular signaling pathways; disease models; therapeutic targets; synergistic effects; natural products; bioactive modulators

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

The Green Revolution in Cancer Research: Bioactive Substances from Plants as Promising Therapeutics

edited by Johura Ansary

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2257 | Submission Open

Keywords: bioactive compound; cancer research; plant-derived; anti-cancer properties; therapeutic strategies

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Advanced Research in Glioblastoma and Neuroblastoma

edited by

Maria G. Bottone

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1828 | Submission Open

Keywords: glioblastoma; neuroblastoma; neuropharmaceuticals; drug design; blood– brain barrier; molecular therapeutics; brain-tumor biomarkers

(This special issue belongs to the Section Molecular Medicine)

Advances in Drug Delivery: Molecular Mechanisms, Therapeutic Applications, and Technologies

edited by

Wenhao Wang

and

Zhengwei Huang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1072 | Submission Open

Keywords: drug delivery; stimulus-responsive drug delivery systems; controlled-release drug delivery systems; theranostics; carrier– biological system interactions; delivery barriers; molecular mechanisms

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Harnessing Genomic Data for Disease Understanding and Drug Discovery

edited by

Gaurav Tripathi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 958 | Submission Open

Keywords: pharmacogenomics; genomics; transcriptomics; epigenomics; drug discovery

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Novel Pharmacological Strategies and Molecular Mechanisms in Nonclinical Research

edited by

Vanessa Mateus

submission deadline 30 Nov 2025 | 1 articles | Viewed by 847 | Submission Open

Keywords: molecular pharmacology; drug targets; signal transduction pathways; nonclinical models; receptor-ligand interactions; pharmacogenomics; preclinical drug development; gene expression modulation; mechanism of action; translational pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Exploring Novel Therapeutic Targets for Neuropsychiatric Disorders: Current Research and Future Direction

edited by Claudia Bregonzio

submission deadline 30 Nov 2025 | Viewed by 126 | Submission Open

Keywords: microvascular alterations; Parkinson’ s disease; Alzheimer disease; schizophrenia; depression

(This special issue belongs to the Section Molecular Medicine)

Advancements in Biomedical Optics and Brain Metabolism

edited by Jennifer M. Lynch

submission deadline 30 Nov 2025 | Viewed by 80 | Submission Open

Keywords: biomedical optics; brain metabolism; optical neuroimaging; cerebral blood flow; near-infrared spectroscopy; diffuse correlation spectroscopy; neurocritical care; noninvasive monitoring; optical biomarkers; brain health

(This special issue belongs to the Section Molecular Medicine)

Future Challenges of Targeted Therapy of Cancers: 2nd Edition

edited by

Simona Gurzu

submission deadline 10 Dec 2025 | 12 articles | Viewed by 18321 | Submission Open

Keywords: biomarkers; tumor tissue; individualized therapy; gene profile; epithelial– mesenchymal transition; immunotherapy; angiogenesis; metastases; oncology; pathology

(This special issue belongs to the Section Molecular Medicine)

Latest Review Papers in Molecular Biology 2025

edited by

Madhav Bhatia

submission deadline 31 Dec 2025 | 23 articles | Viewed by 56367 | Submission Open

Keywords: molecular biology; molecular plant sciences; molecular cell biology; molecular medicine; molecular pathology

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Technological Advances Around Next-Generation Sequencing Application

edited by

Gaurav Tripathi

submission deadline 31 Dec 2025 | 9 articles | Viewed by 25656 | Submission Open

Keywords: next-generation sequencing; single-cell sequencing; long-read sequencing; metagenomics; epigenomics; cancer genomics; clinical applications; liquid biopsy; CRISPR-Cas9; precision medicine; personalized healthcare

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Targeting Tumor Microenvironment for Cancer Therapy, 3rd Edition

edited by

Ming-Wei Lin

and

Cheng-Che Lee

submission deadline 31 Dec 2025 | 10 articles | Viewed by 22432 | Submission Open

Keywords: chemotherapy; cancer; tumor; tumor microenvironment; cancer stem cells; cancer therapy; cancer stemness; chemoresistance

(This special issue belongs to the Section Molecular Medicine)

Natural Compounds: An Adjuvant Strategy in Cancer Management

edited by Monia Cecati and

Arianna Vignini

submission deadline 31 Dec 2025 | 8 articles | Viewed by 22066 | Submission Open

Keywords: cancer; phytochemicals; bioactive compounds; anti-tumor; cancer treatment

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Effects of Environmental Factors on Cardiovascular Disease: From Molecular Effects to Possible Future Clinic Application

edited by

Angelika Edyta Charkiewicz

submission deadline 31 Dec 2025 | 5 articles | Viewed by 18364 | Submission Open

Keywords: environmental factors; cardiovascular diseases; disease and chronic risk; health status; healthy eating; healthy lifestyle; physical activity; alcohol consumption reduction; tobacco cessation; public health; population health; psychosocial factors; dietary recommendations; nutrient intake; health outcomes

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

The Contribution and Application of Molecular Biology in the Applied Biosciences—Focusing on Medicine, Biomaterials and Tissue Engineering Fields, 2nd Edition

edited by

Ioannis Tsamesidis

and

Evangelia Stalika

submission deadline 31 Dec 2025 | 7 articles | Viewed by 13527 | Submission Open

Keywords: medicine; biomaterials; tissue engineering; molecular biology; patients’ reported outcomes; personalized medicine

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Recombinant Proteins for Molecular Biology Research: Technologies and Applications

edited by

Tsutomu Arakawa

and

Yasunari Matsuzaka

submission deadline 31 Dec 2025 | 7 articles | Viewed by 12468 | Submission Open

Keywords: recombinant proteins; vaccine; intra-cellular signaling factors; membrane proteins; drug targets

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advances in Pharmacotherapeutic Strategies to Prevent Tumor Development, Progression and Treatment Resistance, 2nd Edition

edited by

Peter C. Hart

submission deadline 31 Dec 2025 | 4 articles | Viewed by 11404 | Submission Open

Keywords: cancer; therapeutic resistance; drug tolerance; mechanisms of tumor development; mechanisms of tumor progression

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanism of HPV’s Involvement in Cancers

edited by Xuesong Wen

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9786 | Submission Open

Keywords: HPV; HPV carcinogenesis; viral interaction; HPV genotyping; head and neck cancer; immune balance; cervical cancer

(This special issue belongs to the Section Molecular Medicine)

Functional Genomics and Comparative Genomics Analysis in Plants, 3rd Edition

edited by

Quan Zou

, Ran Su and Qiangguo Jin

submission deadline 31 Dec 2025 | 9 articles | Viewed by 8414 | Submission Open

Keywords: de novo genome sequencing; pan-genomic analyses; genome re-sequencing; GWAS analyses; RNA-seq; metabolomics; gene family analyses; plant evolutionary analyses; bioinformatics; database

(This special issue belongs to the Section Molecular Plant Sciences)

Phytochemicals in Cancer Chemoprevention and Treatment: 2nd Edition

edited by

Wojciech Trybus

Ewa Trybus

and

Aneta Wȩgierek-Ciuk

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6731 | Submission Open

Keywords: phytochemicals; chemoprevention; cancer therapy; oxidative stress; apoptosis; autophagy; mitotic catastrophe; cell cycle; cytotoxicity; DNA damage; molecular pathways

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Insights into Cancer Biomarkers: Identification and Practical Applications

edited by

Mihaela Chivu-Economescu

submission deadline 31 Dec 2025 | 5 articles | Viewed by 6664 | Submission Open

Keywords: cancer biomarkers; liquid biopsy; early detection; progression; prognosis; treatment monitoring

(This special issue belongs to the Section Molecular Medicine)

Innovations in Marine Biotechnology and Molecular Biology

edited by Huarong Guo

submission deadline 31 Dec 2025 | 5 articles | Viewed by 6524 | Submission Open

Keywords: marine animal; marine algae; marine microorganism; marine biotechnology; molecular biology

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Oral Cancer: Prophylaxis, Etiopathogenesis and Treatment, 2nd Edition

edited by

Violeta Popovici

and

Emma Adriana Ozon

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6360 | Submission Open

Keywords: oral carcinogenesis; biomarkers; cell signaling; natural products; phytochemicals; medicinal plants; essential oils; antimicrobial activity; cytotoxicity; phytotherapy; drug discovery; drug delivery; pharmaceutical formulation

(This special issue belongs to the Section Molecular Medicine)

Multiple Myeloma: From Molecular Mechanism to Diagnosis and Therapy

edited by

Jari Intra

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6051 | Submission Open

Keywords: multiple myeloma; blood cancer; immunopathogenesis; biomarker; immunoglobulin

(This special issue belongs to the Section Molecular Medicine)

New Immunological Therapeutic Strategies in Kidney Disease

edited by

Yasunari Matsuzaka

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5511 | Submission Open

Keywords: IgA nephritis; IL-23/IL-17 pathway; CAR T-cell therapy; mesenchymal stem cells; innate lymphoid cells

(This special issue belongs to the Section Molecular Medicine)

Feature Papers in Molecular Medicine 2025

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 31 Dec 2025 | 6 articles | Viewed by 4699 | Submission Open

Keywords: pathogenesis; angiogenesis; autoimmune diseases; inflammatory; cancer; cardiovascular diseases; development and differentiation; endocrinology; genetics; epigenetics; hematology; hypoxia research; immunology; infectious diseases; metabolic disorders; neuroscience of diseases; regenerative medicine; prevention; therapeutics; stem cell research

(This special issue belongs to the Section Molecular Medicine)

Applications of Natural and Pseudo-Natural Products in Drug Discovery and Development 2025

edited by

Hidayat Hussain

submission deadline 31 Dec 2025 | 7 articles | Viewed by 4693 | Submission Open

Keywords: natural products; pseudo-natural products; drug discovery; molecular level; in vitro studies; in vivo studies; computational methods; mode of action; computational methods

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Advances in Molecular Therapies and Disease Associations in Diabetes

edited by

Hongbao Cao

and Shaolei Teng

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4204 | Submission Open

Keywords: diabetes; molecular therapies; comorbidities; genomics; proteomics; metabolomics; multi-omics; precision medicine

(This special issue belongs to the Section Molecular Medicine)

The Molecular Basis of Immunotherapy in Cancer Treatment

edited by Hassan Dastsooz

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3777 | Submission Open

Keywords: immunotherapy; cancer; CAR-T cell therapy; monoclonal antibodies; immunomodulation; cytokines; immune evasion mechanisms

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanism and Advances in Gynecological Pathology: From Bench to Bedside

edited by

Ahsanullah Unar

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2985 | Submission Open

Keywords: gynecological cancers; molecular pathology; biomarkers; genetic alterations; epigenetics; tumor microenvironment; personalized medicine; targeted therapy; endometriosis; ovarian cancer

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Functions of Long Non-Coding RNAs: Implications for Diseases and Therapy

edited by

Bodhisattwa Banerjee

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2867 | Submission Open

Keywords: long non-coding RNAs (lncRNAs); gene regulation; molecular mechanisms; chromatin remodeling; epigenetic control; disease pathophysiology; biomarker discovery; therapeutic strategies; translational research

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Breeding and Genetics Research in Plants—3rd Edition

edited by

Shimeles Tilahun

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2607 | Submission Open

Keywords: genetic basis; genomic selection/prediction; molecular breeding; biotic and abiotic stresses; qPCR

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Bioinformatics and Molecular Research on Alzheimer’s Disease

edited by Aristidis G. Vrahatis

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1231 | Submission Open

Keywords: Alzheimer’ s disease; single-cell sequencing; molecular biomarkers; single-cell RNA-seq; single-cell ATAC-seq; spatial transcriptomics

(This special issue belongs to the Section Molecular Medicine)

New Advances in Plant Responses to Environmental Stresses

edited by

Fuyuan Zhu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 786 | Submission Open

Keywords: abiotic stress; functional proteomics; stress response; salt stress; heavy metal stress

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in piRNA Biology and Processing: Mechanisms and Applications

edited by

Yicheng Luo

submission deadline 31 Dec 2025 | Viewed by 371 | Submission Open

Keywords: piRNA; Piwi; transposable elements; epigenetics; genetics; development; cancer

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Design and Synthesis of Bioactive Peptides and Molecular Conjugates for Targeted Drug Delivery

edited by

Ashmeet Singh

submission deadline 31 Dec 2025 | Viewed by 259 | Submission Open

Keywords: peptides; non-covalent synthesis; fluorescent probes; biomaterials; stimuli-responsive; hydrogels; site specific; drug delivery

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Biomaterials for Disease Diagnosis and Therapy: Emerging Molecular Innovations and Applications

edited by Md Tipu Sultan

submission deadline 31 Dec 2025 | Viewed by 127 | Submission Open

Keywords: biomaterials; disease diagnosis; nanoparticles; hydrogels; scaffolds; bio 3D printing; bioink; biosensors; drug delivery; tissue engineering; biocompatibility; translational medicine; cancer; neurodegenerative disorders; disease model; 3D-printed microfluidic devices; organ on a chip; 3D-printed medical devices

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Targeted Therapies and Biomarker Discovery in Health and Disease

edited by

Rodrigo Pinheiro Araldi

submission deadline 31 Dec 2025 | Viewed by 107 | Submission Open

Keywords: multi-omics technologies; targeted therapies; biomarkers; oncology; neurology

(This special issue belongs to the Section Molecular Pharmacology)

Innovative Strategies in Overcoming Antimicrobial Resistance: From Phage Therapy to Combination

edited by Rajnikant Sharma

submission deadline 31 Dec 2025 | Viewed by 106 | Submission Open

Keywords: bacteriophages; phage therapy; antimicrobial resistance; phage engineering; phage-antibiotic combination; phage pharmacokinetics

(This special issue belongs to the Section Molecular Microbiology)

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