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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research in Chronic Dermatoses, 2nd Edition

edited by

Antonio Martorell-Calatayud

and

Piotr K. Krajewski

submission deadline 31 Aug 2025 | 2 articles | Viewed by 16337 | Submission Open

Keywords: dermatopathology; dermatosurgery; skin biology; molecular biology; genetics; JAK inhibitors; antibodies

(This special issue belongs to the Section Molecular Medicine)

The Role of Neuroinflammation in Neurodegenerative Diseases

edited by

Wenqiang Fan

submission deadline 31 Aug 2025 | 6 articles | Viewed by 12676 | Submission Open

Keywords: molecular neuropathology; neuroinflammation; multiple sclerosis; neurodegenerative diseases; dementias

(This special issue belongs to the Section Molecular Medicine)

Natural Products as Potential Sources of Antidiabetic Compounds, 2nd Edition

edited by

Hidayat Hussain

submission deadline 31 Aug 2025 | 5 articles | Viewed by 9564 | Submission Open

Keywords: natural products; natural product derivatives; antidiabetic agents; α -glucosidase inhibitors; amylase inhibitors; PTP1B inhibitors; DPP-4 inhibitors; molecular level; kinetic studies; in vitro studies; in vivo studies; computational methods; mode of action

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Metabolic Interactions Between the Gut Microbiome and Organism

edited by Sree V. Chintapalli

submission deadline 31 Aug 2025 | 4 articles | Viewed by 9472 | Submission Open

Keywords: microbiota dysbiosis; metabolism; inflammation; gut– brain axis; metabolic interactions

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights and Therapeutic Advances in Hematological Disorders

edited by

Eleni Gavriilaki

submission deadline 31 Aug 2025 | 7 articles | Viewed by 8655 | Submission Open

Keywords: acute leukemia; myeloproliferative neoplasms; lymphoma; multiple myeloma; hemoglobinopathies; hemophilia

(This special issue belongs to the Section Molecular Medicine)

Network Pharmacology, Multi-targets and Receptor–Receptor Interactions in the CNS

edited by

Chiara Cervetto

and

Massimo Grilli

submission deadline 31 Aug 2025 | 3 articles | Viewed by 8409 | Submission Open

Keywords: network pharmacology; multi-targets; receptor– receptor interactions; target proteins; drug therapy in CNS; receptors

(This special issue belongs to the Section Molecular Pharmacology)

Linking Genomic Changes with Cancer in the NGS Era, 2nd Edition

edited by Javier Azúa-Romeo and

Paula Paulo

submission deadline 31 Aug 2025 | 6 articles | Viewed by 7370 | Submission Open

Keywords: next-generation sequencing (NGS); genetic variation; driver gene; functional validation; gene editing; cancer

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Mechanisms in Demyelinating Disorders and Remyelination Strategies of the CNS

edited by

Paschalis Theotokis

submission deadline 31 Aug 2025 | 4 articles | Viewed by 7024 | Submission Open

Keywords: demyelination; molecular mechanisms; oligodendrocyte precursor cells; myelinogenesis; dysmyelination; lipid metabolism; microglia and macrophages; experimental autoimmune encephalomyelitis; biomarkers; remyelination

(This special issue belongs to the Section Molecular Medicine)

Editorial Board Members' Collection Series: Natural Product Pharmacology

edited by

Sherif T.S. Hassan

and

Mosharraf Sarker

submission deadline 31 Aug 2025 | 1 articles | Viewed by 4787 | Submission Open

Keywords: natural compounds; bioactive molecules; molecular mechanisms; therapeutic targets; drug discovery; pharmacokinetics; pharmacodynamics; cellular signaling pathways

(This special issue belongs to the Section Molecular Pharmacology)

Cancer Biomarkers: Discovery and Applications

edited by

Po-Ming Chen

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4425 | Submission Open

Keywords: cancer biomarkers; precision medicine; prevention; prognosis; diagnosis

(This special issue belongs to the Section Molecular Medicine)

Genomic Analysis of Common Disease, 2nd Edition

edited by

Golder N. Wilson

submission deadline 31 Aug 2025 | 4 articles | Viewed by 4038 | Submission Open

Keywords: genomic analysis; microarray analysis; whole exome sequencing; pathogenic mutations; copy number variants; DNA sequence variation; intellectual disability; autism; connective tissue dysplasia

(This special issue belongs to the Section Molecular Medicine)

Innovative Strategies and Applications for Drug Discovery

edited by

Wanjoo Chun

submission deadline 31 Aug 2025 | 2 articles | Viewed by 3959 | Submission Open

Keywords: drug discovery; computational strategies; molecular docking; pharmacophore modeling; molecular dynamics simulations

(This special issue belongs to the Section Molecular Medicine)

Mental Disorder: Focus on Pathogenesis to Treatment

edited by

Carmen Concerto

submission deadline 31 Aug 2025 | 4 articles | Viewed by 3892 | Submission Open

Keywords: mental disorders; neurobiological; oxidative stress; neuroinflammation; gene variants

(This special issue belongs to the Section Molecular Medicine)

Insights from Genetics, Epigenetics, and Microbiome Research in Obesity: Integrative Approaches to Understand Metabolic Disorders

edited by Shengping Yang

submission deadline 31 Aug 2025 | 4 articles | Viewed by 3587 | Submission Open

Keywords: obesity; epigenetics; microbiom; genetics; bioinformatics

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Unraveling the Molecular Marvels of Heart Repair and Regeneration

edited by

Nilanjana Maulik

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2713 | Submission Open

Keywords: cardiac repair; angiogenesis; heart failure; ischemia; reperfusion; reactive oxygen; cell therapy; exosome therapy; gene therapy; apoptosis; ischemic preconditioning; gene editing

(This special issue belongs to the Section Molecular Medicine)

The Significance of Transcription Factors, miRNAs, and lncRNAs in Anticancer Drug Development, 2nd Edition

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2411 | Submission Open

Keywords: transcription factors; microRNAs (miRNAs); long non-coding RNAs (lncRNAs); anticancer drugs; cancer; coactivators

(This special issue belongs to the Section Molecular Medicine)

Early Molecular Diagnosis and Comprehensive Treatment of Tumors

edited by

Chan-Yen Kuo

submission deadline 31 Aug 2025 | 3 articles | Viewed by 1887 | Submission Open

Keywords: next-generation sequencing (NGS); novel biomarkers; precision medicine; targeted therapy; immunotherapy; integrative treatment; personalized cancer treatment

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

The Modulatory Effects of Plants with Therapeutic Potential in Neuropsychiatric Disorder

edited by

Alin Ciobica

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1808 | Submission Open

Keywords: plant biodiversity; antioxidant effects; therapeutic potential; neuropsychiatric disorders; oxidative stress markers; inflammatory markers

(This special issue belongs to the Section Molecular Pharmacology)

Hormonal Regulation in Germ Cell Development

edited by

Kwan Sik Min

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1689 | Submission Open

Keywords: spermatogenesis; steroidogenesis; sex hormones; sex hormone receptors; gonadotropin; germ cell differentiation; androgen; luteinizing hormone; follicle-stimulating hormone; glycoprotein hormone receptors

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Bioinformatics Research in Bacterial Genomics, Metagenomics and Metatranscriptomics: 2nd Edition

edited by

Vesselin Baev

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1151 | Submission Open

Keywords: bacterial genomics and functional analysis; genome-wide comparative genomics; bioinformatics methods and tools; metagenomics; metatranscriptomics

(This special issue belongs to the Section Molecular Microbiology)

Mechanisms and Pathophysiology of Obesity

edited by Padmamalini Baskaran

submission deadline 31 Aug 2025 | 1 articles | Viewed by 913 | Submission Open

Keywords: understanding genetic factors for obesity at the molecular level; understanding environmental factors for obesity at the molecular level; contribution of insulin resistance to obesity and ways to combat; circadian misalignment– molecular level understanding of its contribution to obesity and ways to mitigate it; effective and individualized obesity treatment strategies for stress; molecular understanding of the influence of parental obesity on childhood overweight; molecular mechanisms of maternal smoking on childhood obesity; therapeutic interventions for obesity through recombinant hormones; role of gut hormones in the treatment of obesity; development of new digital tools for weight management interventions

(This special issue belongs to the Section Molecular Medicine)

Molecular Research in Osteoarthritis and Osteoarticular Diseases, 2nd Edition

edited by

Ye Liu

submission deadline 31 Aug 2025 | Viewed by 117 | Submission Open

Keywords: osteoarthritis; cartilage regeneration; bioinformatics; biomarkers; inflammation; cartilage; metabolic imbalance

(This special issue belongs to the Section Molecular Medicine)

The Role of the Immune System in the Progression of Chronic Liver Disease

edited by

Ana Maretti-Mira

submission deadline 10 Sep 2025 | 1 articles | Viewed by 5184 | Submission Open

Keywords: autoimmune hepatitis; epigenetics; fatty liver; inflammation; liver fibrosis; liver repair; therapeutic targets and interventions; transcriptomics; viral hepatitis

(This special issue belongs to the Section Molecular Medicine)

Novel Immunotherapy for Neurological Diseases

edited by

Michel-Edwar Mickael

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2021 | Submission Open

Keywords: T cells; immune; neurological disorders; Alzheimer's disease

(This special issue belongs to the Section Molecular Medicine)

Targeting Tumor Microenvironment for Cancer Therapy, 3rd Edition

edited by

Ming-Wei Lin

and

Cheng-Che Lee

submission deadline 30 Sep 2025 | 10 articles | Viewed by 16366 | Submission Open

Keywords: chemotherapy; cancer; tumor; tumor microenvironment; cancer stem cells; cancer therapy; cancer stemness; chemoresistance

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Regulation in Allergy and Immune Diseases, Immunodeficiencies, 2nd Edition

edited by

Kinga Lis

submission deadline 30 Sep 2025 | 4 articles | Viewed by 15040 | Submission Open

Keywords: allergy and hypersensitivity mechanisms; cross-reactivity in allergy; component resolved diagnostic (CRD); immunodeficiencies; experimental research methods in allergology; biochemical properties of allergens

(This special issue belongs to the Section Molecular Medicine)

Tumorigenesis and Tumor Microenvironment

edited by

Yaser Gamallat

submission deadline 30 Sep 2025 | 4 articles | Viewed by 11045 | Submission Open

Keywords: tumorigenesis; tumor growth; tumor progression; tumor metastasis; cancers

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Reproductive Biology and Germ Cell Development, 2nd Edition

edited by

Huafeng Wang

submission deadline 30 Sep 2025 | 5 articles | Viewed by 10095 | Submission Open

Keywords: reproduction; fertilization; sperm; oocyte; signaling; infertility

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Cerebrovascular Diseases: From Pathogenesis to Treatment

edited by

Adria Arboix

Teresa Gasull

and Francisco Purroy

submission deadline 30 Sep 2025 | 8 articles | Viewed by 9806 | Submission Open

Keywords: stroke; ischemic; hemorrhagic; neuronal death; molecular mechanisms; inflammation; epigenetics; ischemic tolerance; ferroptosis; free radicals; treatment

(This special issue belongs to the Section Molecular Medicine)

Human and Animal Infectious Diseases: Prevention, Diagnosis and Treatment, 2nd Edition

edited by

Sherif T.S. Hassan

submission deadline 30 Sep 2025 | 5 articles | Viewed by 7329 | Submission Open

Keywords: bacterial infections; fungal infections; viral infections; infectious microorganisms; molecular medicine techniques; diagnosis; treatment; and prevention approaches; molecular and physiological investigations; cellular and genetic studies; disease pathogenesis; computational methods; drug design and development

(This special issue belongs to the Section Molecular Medicine)

Molecular Research of Urological Diseases

edited by Juhyun Shin

submission deadline 30 Sep 2025 | 5 articles | Viewed by 6838 | Submission Open

Keywords: anticancer drugs; apoptosis mechanism; cell death and proliferation; bioinformatics; natural product

(This special issue belongs to the Section Molecular Medicine)

DNA Damage and Repair in Health and Diseases

edited by

Tomasz Popławski

submission deadline 30 Sep 2025 | 4 articles | Viewed by 6739 | Submission Open

Keywords: DNA damage; DNA repair; DNA repair enzymes; genome stability; oxidative damage; cancers; autoimmune diseases

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Innate Immunity Responds to Virus Infection

edited by Zhenlu Chong

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2952 | Submission Open

Keywords: viral infection; cGAS-STING; RIG-I; toll-like receptors; IFN-I; IFN-III; JAK-STAT pathway; ubiquitination; cellular and molecular studies; animal model

(This special issue belongs to the Section Molecular Microbiology)

Microalga Biotechnology and Applications: Molecular and Cellular Mechanisms

edited by

Angel Llamas

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2237 | Submission Open

Keywords: microalgae; biotechnology; cyanobacteria; chlamydomonas; cellular stress; nutrient limitations; molecular mechanisms; omics technologies

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Targeted Therapeutic Approaches in Cancer: Combining Natural Compounds and Conventional Drugs

edited by

Alok Bhushan

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1506 | Submission Open

Keywords: natural compounds; cancer; repurposing; combination; polychemotherapy; pharmaceuticals; nutraceuticals; molecular targets; metabolomics; immunotherapy

(This special issue belongs to the Section Molecular Medicine)

Molecular Research in Bioactivity of Natural Products, 3rd Edition

edited by

Magdalena Bartnik

and

Wirginia Kukula-Koch

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1131 | Submission Open

Keywords: molecular research; molecular properties; metabolic pathway; phytochemicals; natural products; apoptosis; bioactivity assessment; chemical composition; therapeutic targets

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Research on Virus-Related Infectious Disease

edited by Guangcai Duan and

Shuaiyin Chen

submission deadline 30 Sep 2025 | 1 articles | Viewed by 834 | Submission Open

Keywords: molecular diagnosis of viruses; viral genomics; host– virus interactions; molecular pathways; therapeutic targets; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights into Phytochemicals: Therapeutic Potential in Metabolic Disorders and Cancer

edited by

Mohamed Addi

submission deadline 30 Sep 2025 | 1 articles | Viewed by 683 | Submission Open

Keywords: phytochemicals; molecular mechanisms; cancer therapeutics; metabolic disorders; natural compounds; signal transduction; epigenetic regulation; oxidative stress; anti-inflammatory agents; plant-based

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Post-Translational Modification Networks in Disease and Therapy: From Chromatin Regulation to Protein Stability

edited by

Zhe Yang

submission deadline 30 Sep 2025 | 1 articles | Viewed by 620 | Submission Open

Keywords: post-translational modifications; protein stability; chromatin regulation; phosphorylation; ubiquitination; methylation; acetylation; sumoylation; disease mechanisms; targeted therapy

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Basis of Autoimmune Diseases

edited by

Ranjeet Singh Mahla

submission deadline 30 Sep 2025 | 1 articles | Viewed by 541 | Submission Open

Keywords: autoimmune diseases; immune regulation; molecular mechanisms; genetic predisposition; epigenetics; cytokines; biomarkers; immune checkpoints; targeted therapies; genomics; transcriptomics; proteomics; systems biology; inflammation; immune tolerance

(This special issue belongs to the Section Molecular Medicine)

Molecules at Play in Cardiovascular Diseases

edited by

Dumitru A. Iacobas

submission deadline 30 Sep 2025 | 1 articles | Viewed by 452 | Submission Open

Keywords: arrythmias; arteriosclerosis; congenital heart disease; coronary disease; diabetic cardiomyopathy; dilated cardiomyopathy; endocarditis; high blood pressure; hypertrophic cardiomyopathy; valvular heart diseases

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Therapeutic Advances in Hypertension Management and Vascular Health

edited by

Federica Fogacci

Arrigo Francesco Giuseppe Cicero

and

Claudio Borghi

submission deadline 30 Sep 2025 | Viewed by 160 | Submission Open

Keywords: hypertension; vascular aging; endothelial dysfunction; gestational hypertension; metabolic disorders; therapeutic strategies in hypertension management

(This special issue belongs to the Section Molecular Medicine)

Molecular Impacts of DNA Methylation as Epigenetic Drivers of Disease Onset and Progression

edited by Adam G. Marsh

submission deadline 30 Sep 2025 | Viewed by 106 | Submission Open

Keywords: epigenetics; DNA methylation; disease onset; disease progression; molecular mechanisms; molecular biomarkers; gene silencing; gene expression

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Research on Free Radicals and Oxidative Stress—2nd Edition

edited by

Mosharraf Sarker

submission deadline 30 Sep 2025 | Viewed by 106 | Submission Open

Keywords: oxidative stress; free radicals; reactive oxygen species (ROS); gene regulation; antioxidants; mitochondrial dysfunction; insulin resistance; inflammation; autophagy

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Nanotechnology-Enhanced Photodynamic Therapy for Precision Medicines

edited by

Milutin Stepić

and

Iva A. Popović

submission deadline 30 Sep 2025 | Viewed by 91 | Submission Open

Keywords: photodynamic therapy; photosensitisers; targeting nanocarriers; multifunctional nanoplatforms; nanotheranostics; active targeting of cancer; molecular drug targeting; drug metabolism and toxicity; pharmacogenetic testing; cancer microenvironment remodelling

(This special issue belongs to the Section Molecular Medicine)

Cancer Genetics and Pharmacology: Advancing Precision Therapeutics

edited by Baoming Wang

submission deadline 30 Sep 2025 | Viewed by 78 | Submission Open

Keywords: cancer genetics; epigenetic modifications; pharmacogenomics; personalized medicine

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

The Molecular Pathways Involved in Atopic Dermatitis: Implications for Targeted Therapy

edited by

Ciro Martins Gomes

submission deadline 30 Oct 2025 | Viewed by 99 | Submission Open

Keywords: atopic dermatitis; biological products; cytokines; Th2 cells; eczema; Janus kinase inhibitors

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Roles of Neutrophil Extracellular Traps in Immune Responses and Disease

edited by Sofía S. Jerez

submission deadline 30 Oct 2025 | Viewed by 76 | Submission Open

Keywords: neutrophils; NET; inflammation; chronic diseases; cell death

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Role of Natural Products in Inflammatory Diseases

edited by

Chingyuan Wu

submission deadline 31 Oct 2025 | 6 articles | Viewed by 15476 | Submission Open

Keywords: natural compounds; phytochemicals; bioactivity; IL-1; caspases; inflammasome; proinflammatory cytokines; psoriasis

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Mechanisms and Innovative Therapeutic Approaches in Inflammatory Diseases, Pioneering Precision Medicine Solutions

edited by

Hector A. Cabrera-Fuentes

Klaus T. Preissner

and

Elisabeth Deindl

submission deadline 31 Oct 2025 | 13 articles | Viewed by 13119 | Submission Open

Keywords: inflammatory diseases; autoimmune disorders; cytokine signaling; oxidative stress; therapies

(This special issue belongs to the Section Molecular Medicine)

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