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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Roles of Neutrophil Extracellular Traps in Immune Responses and Disease

edited by Sofía S. Jerez

submission deadline 30 Oct 2025 | 1 articles | Viewed by 580 | Submission Open

Keywords: neutrophils; NET; inflammation; chronic diseases; cell death

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

The Molecular Pathways Involved in Atopic Dermatitis: Implications for Targeted Therapy

edited by

Ciro Martins Gomes

submission deadline 30 Oct 2025 | Viewed by 148 | Submission Open

Keywords: atopic dermatitis; biological products; cytokines; Th2 cells; eczema; Janus kinase inhibitors

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Role of Natural Products in Inflammatory Diseases

edited by

Chingyuan Wu

submission deadline 31 Oct 2025 | 7 articles | Viewed by 21149 | Submission Open

Keywords: natural compounds; phytochemicals; bioactivity; IL-1; caspases; inflammasome; proinflammatory cytokines; psoriasis

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Mechanisms and Innovative Therapeutic Approaches in Inflammatory Diseases, Pioneering Precision Medicine Solutions

edited by

Hector A. Cabrera-Fuentes

Klaus T. Preissner

and

Elisabeth Deindl

submission deadline 31 Oct 2025 | 13 articles | Viewed by 17124 | Submission Open

Keywords: inflammatory diseases; autoimmune disorders; cytokine signaling; oxidative stress; therapies

(This special issue belongs to the Section Molecular Medicine)

Novel Drugs and Natural Products Discovery

edited by

Muhammad Khattab

submission deadline 31 Oct 2025 | 10 articles | Viewed by 16191 | Submission Open

Keywords: natural products; novel drugs; drug design

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Complex Molecular Mechanism of Monogenic Diseases: 3rd Edition

edited by

Grzegorz Wegrzyn

submission deadline 31 Oct 2025 | 2 articles | Viewed by 12571 | Submission Open

Keywords: cystic fibrosis; sickle cell disease; duchenne muscular dystrophy; inherited monogenic disease; molecular mechanisms

(This special issue belongs to the Section Molecular Medicine)

Molecular Biology of Viral Replication and Associated Disease Outcomes

edited by Usama Ashraf

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6244 | Submission Open

Keywords: viruses; replication; immunity; pathogenesis; antivirals; immune modulator

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Gut Microbiota in Health, Immunity and Disease

edited by

Ahmad Ud Din

submission deadline 31 Oct 2025 | 2 articles | Viewed by 5166 | Submission Open

Keywords: gut microbiome; immune system; probiotics; prebiotics; microbial metabolites; microbiota– host interactions; gut– brain axis

(This special issue belongs to the Section Molecular Microbiology)

Challenges and Advances in Bioinformatics and Computational Biology

edited by Haijun Gong

submission deadline 31 Oct 2025 | 4 articles | Viewed by 4963 | Submission Open

Keywords: bioinformatics; computational biology; genomics; proteomics; metabolomics; multi-omics; machine learning; AI; big data; molecular diagnostics; personalized medicine; data visualization

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Mechanism and Regulation in Neuroinflammation, 2nd Edition

edited by Hung-Pei Tsai

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4433 | Submission Open

Keywords: microglia; glial cells; cytokines; blood– brain barrier; traumatic brain injury; aging; Alzheimer's disease; parkinson's disease; amyotrophic lateral sclerosis; multiple sclerosis

(This special issue belongs to the Section Molecular Medicine)

Pathogenesis, Diagnosis and Treatment of Skin and Sexually Transmitted Diseases

edited by

Maria Eleni Manthou

, Efstratios Vakirlis and

Iasonas Dermitzakis

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1662 | Submission Open

Keywords: pathogenesis; diagnosis; treatment; dermatology; STDs; molecular; immunology; inflammation; genomics; precision

(This special issue belongs to the Section Molecular Medicine)

Mitochondrial Genomes 2025: Unraveling the Threads of Evolution and Function

edited by Hongyi Liu

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1007 | Submission Open

Keywords: mitogenomes; mitochondria genomes; molecular evolution

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

The Emerging Role of Molecular and Serum Biomarkers in Osteoporosis

edited by

Francesca Salamanna

and

Stefania Pagani

submission deadline 31 Oct 2025 | Viewed by 309 | Submission Open

Keywords: osteoporosis; biomarkers; PINP; CTX; bone metabolism

(This special issue belongs to the Section Molecular Medicine)

Natural Products in Biomedicine and Pharmacotherapy, 2nd Edition

edited by

Ahmed Ezat El Zowalaty

submission deadline 31 Oct 2025 | Viewed by 268 | Submission Open

Keywords: natural products; genetic engineering; pharmacotherapy; anticancer; antimicrobials

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Medicinal Plants and Phytochemicals for the Prevention and Intervention of Metabolic Disease and Its Complications

edited by

Sandra Barbalho

submission deadline 31 Oct 2025 | Viewed by 167 | Submission Open

Keywords: metabolic diseases; phytochemicals; medicinal plants; metabolic diseases complications; functional foods

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Mechanisms and Pharmacological Underlying Cardiorenal Diseases

edited by

Caterina Carollo

submission deadline 31 Oct 2025 | Viewed by 130 | Submission Open

Keywords: hypertension; cardio-renal syndromes; heart failure; chronic kidney disease; hemodialysis; periotenal dialysis

(This special issue belongs to the Section Molecular Medicine)

Oxidative Stress in Cancer Biology

edited by

Eugenia Yiannakopoulou

submission deadline 31 Oct 2025 | Viewed by 120 | Submission Open

Keywords: reactive oxygen species (ROS); redox homeostasis; oxidative DNA damage; antioxidant defense mechanisms; Nrf2 signaling pathway; mitochondrial dysfunction; tumor microenvironment; cancer cell survival and proliferation

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights and Unique Characteristics in Adolescent and Young Adult Oncology

edited by

Antonio Ruggiero

submission deadline 31 Oct 2025 | Viewed by 100 | Submission Open

Keywords: adolescent; young adult; biology; treatment; outcome

(This special issue belongs to the Section Molecular Medicine)

Protein Domains: Structure and Molecular Function

edited by Guangfeng Zhou

submission deadline 10 Nov 2025 | 4 articles | Viewed by 10742 | Submission Open

Keywords: protein structure; protein domains; domain classification; protein engineering; protein design; protein modeling; machine learning; deep learning; protein structure prediction; protein function prediction

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Neuropituitary Hormones in Metabolic Disorders

edited by

Claudia Camerino

submission deadline 10 Nov 2025 | Viewed by 133 | Submission Open

Keywords: oxytocin; vasopressin; thermoregulation; obesity; Prader– Willi syndrome; autism spectrum disorder; anorexia nervosa; craniopharyngioma; metabolic disorders; hypothalamic pituitary disorders; oxytocin-deficiency; vasopressin-deficiency

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Modulation of Oxidative Stress: A Global Perspective for Climate Change Adaptation

edited by

Tihomir Kovač

and

Tihana Marček

submission deadline 15 Nov 2025 | Viewed by 251 | Submission Open

Keywords: oxidative stress; modulation; climate change; environmental factors; adaption

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Biology in Dentistry: Innovations in Diagnosis, Treatment, and Biomaterials

edited by

Maria Maddalena Marrapodi

and Valentina Belli

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4738 | Submission Open

Keywords: oral microbiome; tissue regeneration; biomimetic materials

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Research on Virus-Induced Cellular and Molecular Responses

edited by

Rudian Zhang

submission deadline 30 Nov 2025 | 6 articles | Viewed by 13479 | Submission Open

Keywords: virus infectivity; infectious diseases; cellular stress; autophagy

(This special issue belongs to the Section Molecular Microbiology)

Natural Product in Skin Inflammation and Barrier Function Damage

edited by

Hsiu-Mei Chiang

submission deadline 30 Nov 2025 | 3 articles | Viewed by 7925 | Submission Open

Keywords: skin inflammation; barrier function damage; natural compounds; antioxidant properties; antiaging

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Radiation Oncology

edited by Allen Chen

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5411 | Submission Open

Keywords: molecular and cellular radiobiology; radiation physics; DNA damage and repair; radiation response; cancers

(This special issue belongs to the Section Molecular Medicine)

Cardiovascular Disease: From Molecular Mechanisms to Therapeutic Innovations

edited by Andrea Marzullo

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4454 | Submission Open

Keywords: cardiovascular pathophysiology; molecular biomarkers; inflammation and oxidative stress; therapeutic targets; lipid metabolism

(This special issue belongs to the Section Molecular Medicine)

Omics Analysis for Personalized Medicine

edited by

Golder N. Wilson

and

Tadeja Kuret

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4220 | Submission Open

Keywords: genomics; epigenomics; transcriptomics; proteomics; metabolomics; multi-omics; high throughput; personalized medicine; immune-mediated inflammatory diseases

(This special issue belongs to the Section Molecular Medicine)

Tumor Immunology: From Molecular Mechanisms to Treatment

edited by

Deepika Awasthi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3016 | Submission Open

Keywords: cellular metabolism; metabolic reprogramming; immunometabolism; tumor microenvironment; immunotherapy; metabolites; immunosuppression; immune cells; tumor cells

(This special issue belongs to the Section Molecular Medicine)

Molecular Keys to Bioactivity: Pharmacophore and SAR Exploration in Organic Compounds

edited by

Claudiu N. Lungu

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2072 | Submission Open

Keywords: structure– activity relationship; pharmacophore; chirality; bioactive molecules; morphogenesis; protein targets; membrane interaction; natural products; synthetic organic compounds; drug discovery

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

The Role of Bioactives in Inflammation, 2nd Edition

edited by

Chan-Yen Kuo

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1831 | Submission Open

Keywords: anti-inflammation; bioactives; drug research and development; inflammatory diseases; natural products; signaling; synthesized compounds

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

The Green Revolution in Cancer Research: Bioactive Substances from Plants as Promising Therapeutics

edited by Johura Ansary

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1753 | Submission Open

Keywords: bioactive compound; cancer research; plant-derived; anti-cancer properties; therapeutic strategies

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Advanced Research in Glioblastoma and Neuroblastoma

edited by

Maria G. Bottone

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1617 | Submission Open

Keywords: glioblastoma; neuroblastoma; neuropharmaceuticals; drug design; blood– brain barrier; molecular therapeutics; brain-tumor biomarkers

(This special issue belongs to the Section Molecular Medicine)

Mechanistic Insights into the Antioxidant Activity of Bioorganic Molecules: A Chemical Perspective

edited by

Tatjana S. Radosavljević

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1593 | Submission Open

Keywords: antioxidant mechanisms; bioorganic molecules; redox -active compounds; molecular reactivity; oxidative stress modulation

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Natural Phytochemicals as Modulators of Cellular Pathways and Therapeutic Targets in Disease Models

edited by

Jui-Hung Yen

submission deadline 30 Nov 2025 | 1 articles | Viewed by 883 | Submission Open

Keywords: phytochemicals; cellular signaling pathways; disease models; therapeutic targets; synergistic effects; natural products; bioactive modulators

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Advances in Drug Delivery: Molecular Mechanisms, Therapeutic Applications, and Technologies

edited by

Wenhao Wang

and

Zhengwei Huang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 865 | Submission Open

Keywords: drug delivery; stimulus-responsive drug delivery systems; controlled-release drug delivery systems; theranostics; carrier– biological system interactions; delivery barriers; molecular mechanisms

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Harnessing Genomic Data for Disease Understanding and Drug Discovery

edited by

Gaurav Tripathi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 787 | Submission Open

Keywords: pharmacogenomics; genomics; transcriptomics; epigenomics; drug discovery

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Novel Pharmacological Strategies and Molecular Mechanisms in Nonclinical Research

edited by

Vanessa Mateus

submission deadline 30 Nov 2025 | 1 articles | Viewed by 471 | Submission Open

Keywords: molecular pharmacology; drug targets; signal transduction pathways; nonclinical models; receptor-ligand interactions; pharmacogenomics; preclinical drug development; gene expression modulation; mechanism of action; translational pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Repurposing and Innovation: Drug Research in Neuroprotection

edited by

Stela Dragomanova

submission deadline 30 Nov 2025 | Viewed by 150 | Submission Open

Keywords: neuroprotection; drug repurposing; natural-derived compounds; neurodegenerative diseases; pharmacological innovation

(This special issue belongs to the Section Molecular Pharmacology)

Exploring Novel Therapeutic Targets for Neuropsychiatric Disorders: Current Research and Future Direction

edited by Claudia Bregonzio

submission deadline 30 Nov 2025 | Viewed by 112 | Submission Open

Keywords: microvascular alterations; Parkinson’ s disease; Alzheimer disease; schizophrenia; depression

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Biomarker Discovery in Neurodegenerative Disorders

edited by

George P. Paraskevas

submission deadline 30 Nov 2025 | Viewed by 98 | Submission Open

Keywords: neurodegenerative diseases; molecular biomarkers; cerebrospinal fluid (CSF) biomarkers; positron emission tomography (PET); seeding amplification assay (SAA); plasma biomarkers

(This special issue belongs to the Section Molecular Medicine)

Biochar as a Soil Amendment: Unraveling Molecular Mechanisms Underpinning Plant Growth Promotion via Gene Expression and Regulatory Networks

edited by

Kumuduni Palansuriya

submission deadline 30 Nov 2025 | Viewed by 95 | Submission Open

Keywords: biochar; soil amendment; plant growth promotion; soil health; soil fertility; nutrient availability; rhizosphere interactions; agricultural productivity; sustainable soil management; organic amendments

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Biology and Biochemistry of Cannabis: Exploring the Genetic and Metabolic Pathways

edited by Craig M. Schluttenhofer

submission deadline 30 Nov 2025 | Viewed by 78 | Submission Open

Keywords: cannabis sativa; molecular biology; phytochemical pathways; cannabinoid receptors; genomics; neurobiology; immunomodulation; plant– microbe interactions

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advancements in Biomedical Optics and Brain Metabolism

edited by Jennifer M. Lynch

submission deadline 30 Nov 2025 | Viewed by 70 | Submission Open

Keywords: biomedical optics; brain metabolism; optical neuroimaging; cerebral blood flow; near-infrared spectroscopy; diffuse correlation spectroscopy; neurocritical care; noninvasive monitoring; optical biomarkers; brain health

(This special issue belongs to the Section Molecular Medicine)

Future Challenges of Targeted Therapy of Cancers: 2nd Edition

edited by

Simona Gurzu

submission deadline 10 Dec 2025 | 11 articles | Viewed by 13218 | Submission Open

Keywords: biomarkers; tumor tissue; individualized therapy; gene profile; epithelial– mesenchymal transition; immunotherapy; angiogenesis; metastases; oncology; pathology

(This special issue belongs to the Section Molecular Medicine)

Latest Review Papers in Molecular Biology 2025

edited by

Madhav Bhatia

submission deadline 31 Dec 2025 | 20 articles | Viewed by 41007 | Submission Open

Keywords: molecular biology; molecular plant sciences; molecular cell biology; molecular medicine; molecular pathology

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Technological Advances Around Next-Generation Sequencing Application

edited by

Gaurav Tripathi

submission deadline 31 Dec 2025 | 9 articles | Viewed by 21067 | Submission Open

Keywords: next-generation sequencing; single-cell sequencing; long-read sequencing; metagenomics; epigenomics; cancer genomics; clinical applications; liquid biopsy; CRISPR-Cas9; precision medicine; personalized healthcare

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Natural Compounds: An Adjuvant Strategy in Cancer Management

edited by Monia Cecati and

Arianna Vignini

submission deadline 31 Dec 2025 | 8 articles | Viewed by 16356 | Submission Open

Keywords: cancer; phytochemicals; bioactive compounds; anti-tumor; cancer treatment

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Effects of Environmental Factors on Cardiovascular Disease: From Molecular Effects to Possible Future Clinic Application

edited by

Angelika Edyta Charkiewicz

submission deadline 31 Dec 2025 | 5 articles | Viewed by 13003 | Submission Open

Keywords: environmental factors; cardiovascular diseases; disease and chronic risk; health status; healthy eating; healthy lifestyle; physical activity; alcohol consumption reduction; tobacco cessation; public health; population health; psychosocial factors; dietary recommendations; nutrient intake; health outcomes

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Recombinant Proteins for Molecular Biology Research: Technologies and Applications

edited by

Tsutomu Arakawa

and

Yasunari Matsuzaka

submission deadline 31 Dec 2025 | 7 articles | Viewed by 10548 | Submission Open

Keywords: recombinant proteins; vaccine; intra-cellular signaling factors; membrane proteins; drug targets

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

The Contribution and Application of Molecular Biology in the Applied Biosciences—Focusing on Medicine, Biomaterials and Tissue Engineering Fields, 2nd Edition

edited by

Ioannis Tsamesidis

and

Evangelia Stalika

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10484 | Submission Open

Keywords: medicine; biomaterials; tissue engineering; molecular biology; patients’ reported outcomes; personalized medicine

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

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