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Advanced Biomaterials, Coatings and Techniques: Applications in Medicine and Dentistry, ...
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Advanced Biomaterials, Coatings and Techniques: Applications in Medicine and Dentistry, 2nd Edition

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: 25 May 2026 | Viewed by 6456

Special Issue Editors

Prof. Dr. Lavinia Cosmina Ardelean

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Guest Editor
Department of Technology of Materials and Devices in Dental Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania
Interests: dental materials/biomaterials; alloys; ceramics; thermoplastic resins; 3D printing/bioprinting; CAD/CAM milling; corrosion evaluation; welding; scanning; coating; oral health; dental caries
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Laura-Cristina Rusu

E-Mail Website
Guest Editor
Department of Oral Pathology, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania
Interests: oral medicine; oral pathology; dental materials; nanomaterials; biomaterials; oral microbiome; oral biofilm; oral cancer; nanomedicine; oral microenvironment; oral biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite you to submit a manuscript to this Special Issue, “Advanced Biomaterials, Coatings and Techniques: Applications in Medicine and Dentistry, 2nd Edition”.

The field of biomaterials is very extensive, encompassing both the materials themselves and their manufacturing methods, which are constantly developing.

The use of biomaterials for medical and oral applications is associated with specific issues concerning their biocompatibility, bio-integration, antimicrobial properties, corrosion resistance and long-term performance, which arise due to their close contact with human tissues. In the field of regenerative medicine, biomaterials are of great importance when used as scaffolds to promote cell growth and differentiation, resulting in the healing of tissue lesions.

Coatings are crucial to obtaining the most significant properties of biomaterials via surface modification, making them suitable for medical and oral applications.

This Special Issue aims to provide an updated outlook on the applications of biomaterials and coatings in medicine and dentistry and present innovative manufacturing technologies. It seeks to serve as a forum for researchers and scholars from across the world to report their research findings on this topic. We welcome research articles, reviews, and communications.

Prof. Dr. Lavinia Cosmina Ardelean
Prof. Dr. Laura-Cristina Rusu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • dental materials
  • novel technologies
  • protective coatings
  • bioactive coatings
  • antibacterial coatings
  • regenerative medicine

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Related Special Issue

Published Papers (6 papers)

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Research

18 pages, 2577 KB  
Article
Preparation of Composite Resin Coatings and Its Performance Improvement on Ti-Based Dental Implants
by Siqi Zhu, Chao Yao, Xiaopan Li, Yifan Yuan, Mengmeng Chen, Yiyun Kong, Yujie Fan, Jing Xia and Chun Yao
Coatings 2026, 16(4), 475; https://doi.org/10.3390/coatings16040475 - 15 Apr 2026
Viewed by 238
Abstract
Titanium alloys are widely used in dental implants due to their excellent mechanical properties. However, their inertness and poor antibacterial activity cause interfacial loosening and failure, shortening service life. This study integrates surface microtexturing with coating technologies, employing modified light-curing composite resins to [...] Read more.
Titanium alloys are widely used in dental implants due to their excellent mechanical properties. However, their inertness and poor antibacterial activity cause interfacial loosening and failure, shortening service life. This study integrates surface microtexturing with coating technologies, employing modified light-curing composite resins to boost the bioactivity of medical titanium alloys via surface modification. The results reveal that surface microtexturing enlarges the coating-substrate contact area by 42.5% compared with rough surfaces, concurrently diminishing stress per unit area, and the coating on microtextured Ti-6Al-4V (TC4) surfaces achieves adhesion with a damaged area of only 0.5%, thereby notably enhancing adhesion between the coating and TC4 matrix. In comparison, with rough surfaces (surface roughness of 0.658 μm), smooth TC4 planes (surface roughness of 0.014 μm) show a significantly reduced bacterial colony count (from 130 ± 6 to 42 ± 3) with an antibacterial rate of 67.7%, as the water contact angle on TC4 surfaces increases with decreasing roughness (reaching 80.95° on the smoothest surface), making bacterial adhesion more challenging and reducing colonization. The composite resin coating based on a mixture of titanium-doped hydroxyapatite and titanium dioxide (Ti-HA/TiO2) further improves the antibacterial rate to 74.6% through a photocatalytic synergistic effect and endows TC4 with excellent remineralization capacity—mineralization deposits appear on the coated surface after 3 days of immersion in artificial saliva, while no obvious deposits are found on uncoated rough and smooth surfaces even after 7 days—thereby enhancing its bioactivity effectively. This study on the modification of Ti-based implant surfaces will enrich the field by introducing new technologies and methodologies. These advancements provide a theoretical basis for improvement of the remineralization capacity and antibacterial properties of Ti-based dental implants, thereby promoting broader biomedical applications. Full article
(This article belongs to the Special Issue Advanced Biomaterials, Coatings and Techniques: Applications in Medicine and Dentistry, 2nd Edition)
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14 pages, 816 KB  
Article
Tensile Bond Strength Between Zirconia and PEEK Blocks: A Polymer–Ceramic Adhesive Interface Study
by Bora Akat, Ezgi Su Sarıal, Fehmi Gönüldaş and Mehmet Ali Kılıçarslan
Coatings 2026, 16(1), 33; https://doi.org/10.3390/coatings16010033 - 28 Dec 2025
Cited by 1 | Viewed by 1651
Abstract
Reliable bonding between zirconia and PEEK surfaces is crucial for ensuring the long-term success of hybrid prosthetic restorations. This study aimed to evaluate the tensile bond strength of zirconia–PEEK specimens prepared using different primer strategies to determine the most effective adhesive protocol. One [...] Read more.
Reliable bonding between zirconia and PEEK surfaces is crucial for ensuring the long-term success of hybrid prosthetic restorations. This study aimed to evaluate the tensile bond strength of zirconia–PEEK specimens prepared using different primer strategies to determine the most effective adhesive protocol. One hundred bonded specimens were divided into four groups (n = 25): control (no primer), zirconia primer (MKZ Primer), PEEK primer (Visio.link), and dual primer application. Specimens underwent sandblasting with 110 µm Al2O3 particles at 2 bar pressure for 15 s, and the PEEK primer was light-cured using a Valo Grand LED curing unit (1000 mW/cm2, 90 s). All samples were bonded using the same universal adhesive and resin cement, and tensile bond strength was measured with a micro-tensile testing device. Data were analyzed using one-way ANOVA and Tukey’s HSD test (α = 0.05). The mean bond strengths were 12.83 MPa (control), 15.05 MPa (zirconia primer), 90.50 MPa (PEEK primer), and 102.09 MPa (dual primer). Application of PEEK primer significantly enhanced adhesion compared to zirconia primer or control (p < 0.001), while dual primer use yielded the highest values, indicating a synergistic effect. These findings suggest that surface-specific priming of both zirconia and PEEK surfaces effectively improves polymer–ceramic bonding performance and may contribute to the clinical durability of hybrid prosthetic restorations. Full article
(This article belongs to the Special Issue Advanced Biomaterials, Coatings and Techniques: Applications in Medicine and Dentistry, 2nd Edition)
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18 pages, 1595 KB  
Article
Effect of Nanosilica Fillers on Photopolymerisation Behaviour and Mechanical Performance of Dental Resin Composites
by Mariola Robakowska and Łukasz Gierz
Coatings 2025, 15(11), 1316; https://doi.org/10.3390/coatings15111316 - 11 Nov 2025
Cited by 1 | Viewed by 738
Abstract
The performance of dental composites is strongly dependent on the type and content of ceramic fillers incorporated into the resin matrix. In this study, the effect of nanosilica (NS) fillers on the curing kinetics, physicochemical, thermal, and mechanical properties of Bis-GMA/TEGDMA-based dental composites [...] Read more.
The performance of dental composites is strongly dependent on the type and content of ceramic fillers incorporated into the resin matrix. In this study, the effect of nanosilica (NS) fillers on the curing kinetics, physicochemical, thermal, and mechanical properties of Bis-GMA/TEGDMA-based dental composites was systematically investigated. A series of nanocomposites containing various weight fractions of NS was prepared and evaluated. The photocuring behaviour was analysed using differential scanning calorimetry (DSC), enabling the determination of polymerisation rate coefficients (propagation kp and bimolecular termination ktb) and double bond conversion. The presence of nanosilica was found to influence chain mobility, as evidenced by changes in glass transition temperature (Tg). Rheological measurements provided insight into viscosity changes induced by NS incorporation, while mechanical tests confirmed reinforcement effects. A moderate but statistically significant correlation was observed between the NS content and mechanical performance. The results obtained correlate the rheological, kinetic, thermal, and mechanical properties of multiple types of silica in a single resin system using a consistent methodology. In addition, the results highlight the role of nanosilica in the regulation of the curing dynamics and the increase in the mechanical integrity of methacrylate-based dental composites, representing a promising strategy for the development of next-generation restorative materials. Full article
(This article belongs to the Special Issue Advanced Biomaterials, Coatings and Techniques: Applications in Medicine and Dentistry, 2nd Edition)
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16 pages, 5948 KB  
Article
Physicochemical, Microstructural and Biological Evaluation of Dressing Materials Made of Chitosan with Different Molecular Weights
by Zofia Płonkowska, Alicja Wójcik and Vladyslav Vivcharenko
Coatings 2025, 15(10), 1116; https://doi.org/10.3390/coatings15101116 - 24 Sep 2025
Viewed by 1275
Abstract
The use of advanced wound dressings can significantly support the skin healing process by maintaining optimal conditions for tissue regeneration. In this study, foam-like dressings composed of agarose and chitosan, enriched with vitamin C, were developed using a simple and cost-effective freeze-drying method. [...] Read more.
The use of advanced wound dressings can significantly support the skin healing process by maintaining optimal conditions for tissue regeneration. In this study, foam-like dressings composed of agarose and chitosan, enriched with vitamin C, were developed using a simple and cost-effective freeze-drying method. Three types of chitosan with varying molecular weights (low, medium, high) were used to investigate their impact on the biological, physicochemical, and mechanical properties of the resulting foams. All fabricated biomaterials were biocompatible, non-toxic, and did not promote cell adhesion to their surfaces. The foams exhibited highly porous, hydrophilic microstructures with excellent fluid absorption capacity (~20 mL/g) and sustained vitamin C release over the first 24 h. Chitosan molecular weight had no significant effect on biological properties, but influenced samples’ wettability and mechanical parameters. The hydrophilic character of samples was observed in all tested biomaterials, with the strongest enhancement of hydrophilicity noted for the low molecular weight variant. The highest tensile strength was observed in samples prepared with medium molecular weight chitosan. The results indicate that among the analyzed variants, agarose-chitosan foam biomaterials containing medium molecular weight chitosan exhibited the most favorable properties, making them the most promising candidates for the treatment of wounds with excessive exudate. Full article
(This article belongs to the Special Issue Advanced Biomaterials, Coatings and Techniques: Applications in Medicine and Dentistry, 2nd Edition)
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15 pages, 4443 KB  
Article
Effects of Ti6Al4V Substrate Roughness on the Surface Morphology, Mechanical Properties, and Cell Proliferation of Diamond-like Carbon Films
by Chehung Wei, Bo-Cheng Wu and Min-Sheng Hung
Coatings 2025, 15(9), 1086; https://doi.org/10.3390/coatings15091086 - 16 Sep 2025
Viewed by 884
Abstract
This study investigated how Ti6Al4V substrate topography affects the performance of diamond-like carbon (DLC) coatings. Substrates with four finishes (unpolished, #100, #400, #800 grit) were coated, and their morphology, wettability, bonding structure, mechanical properties, and biological response were examined. Characterization was performed using [...] Read more.
This study investigated how Ti6Al4V substrate topography affects the performance of diamond-like carbon (DLC) coatings. Substrates with four finishes (unpolished, #100, #400, #800 grit) were coated, and their morphology, wettability, bonding structure, mechanical properties, and biological response were examined. Characterization was performed using AFM, SEM, contact angle tests, Raman spectroscopy, and nanoindentation. Biocompatibility was evaluated with A549 epithelial cells. DLC deposition reduced roughness while partly preserving surface features. Increasing Ra was associated with lower surface free energy and ID/IG ratios. It also correlated with higher hardness and modulus, reflecting greater sp3 bonding. Biological results, however, indicated that surface organization was more decisive than Ra magnitude. The #100-grit surface, with aligned anisotropic grooves, supported uniform wetting, protein adsorption, and sustained proliferation. In contrast, the unpolished and smoother surfaces did not maintain long-term growth. These findings suggest that anisotropy, rather than Ra alone, plays a key role in optimizing DLC-coated Ti6Al4V implants. Full article
(This article belongs to the Special Issue Advanced Biomaterials, Coatings and Techniques: Applications in Medicine and Dentistry, 2nd Edition)
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13 pages, 2316 KB  
Article
Atomic Layer Deposition of Zirconia on Cobalt–Chromium Alloys for Dental Prosthetics: Surface Functionalization Under MDR 2017/745
by Anna Ziębowicz and Mirosława Pawlyta
Coatings 2025, 15(9), 994; https://doi.org/10.3390/coatings15090994 - 27 Aug 2025
Viewed by 1089
Abstract
The primary goal of this study was to assess the suitability of the proposed method for modifying the surface of cobalt alloys in dental prosthetics, taking into account the specific characteristics of the stomatognathic system during long-term use and their impact on physicochemical [...] Read more.
The primary goal of this study was to assess the suitability of the proposed method for modifying the surface of cobalt alloys in dental prosthetics, taking into account the specific characteristics of the stomatognathic system during long-term use and their impact on physicochemical properties and the adhesion of cariogenic bacteria such as Streptococcus mutans. Technological factors influencing the quality of the product and its final dimensional characteristics were considered, confirming or ruling out the possibility of iatrogenic errors (related to poorly shaped prostheses) occurring during laboratory fabrication. This study demonstrates that atomic layer deposition of ZrO2 on CoCr dental alloys results in a chemically stable, uniform, and protective surface layer, reducing ion release and improving surface quality. These improvements address key safety and performance requirements outlined in MDR 2017/745, supporting the use of ALD as a state-of-the-art technique for functionalizing dental prosthetic devices. Such coating development may influence the final quality of the denture and also verify its suitability for use in the oral environment (reducing the likelihood of denture stomatitis). Full article
(This article belongs to the Special Issue Advanced Biomaterials, Coatings and Techniques: Applications in Medicine and Dentistry, 2nd Edition)
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