Recent Advances in Bioceramic Coatings for Medical Implant Applications

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 778

Special Issue Editors


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Guest Editor
Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11351 Belgrade, Serbia
Interests: biomaterials; thin films and coatings; bone tissue engineering
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11351 Belgrade, Serbia
Interests: nanomedicine; tissue engineering; surface modification of medical devices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Medical implants are synthetic materials that are implanted into the human body for various medical purposes, such as the replacement of body parts like hips and knees, supporting organs and tissues, monitoring and regulating body functions like heart rate, and the delivery of medications to specific sites within the body. Implant materials have been advanced to the level that they may effectively replace and/or restore the function of damaged tissues. The application of metal implants in orthopaedics has considerably enhanced the quality of life for many people. Many factors influence the clinical success of an implant, especially material selection, adequate design, and biocompatibility. Implanted materials must develop a stable interface with surrounding tissue while also being mechanically compatible with native tissue, which is very difficult to achieve. When it comes to the metallic implants used in orthopaedics, they meet many of the biomechanical requirements. However, there is little to no interfacial bonding between the metallic surface and the surrounding bone, causing the creation of a non-adherent, fibrous tissue layer. This further leads to the formation of small gaps between the bone and the implant, allowing mobility at the implant–tissue interface and eventually causing implant failure. A possible solution to this problem lies in application of ceramic coatings to the implant surface, thus providing a bioactive interface between the metal implant and surrounding tissue. Recent investigations have shown that bioceramic coatings deposited by various deposition technologies can improve the performance and reliability of existing medical implants, by improving their bioactivity, blood compatibility, and wear and corrosion resistance.

We look forward to receiving your contributions dealing with all aspect of this broad and interesting topic.

Dr. Božana Petrović
Prof. Dr. Vukoman Jokanovic
Guest Editors

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Keywords

  • bioceramics
  • coatings
  • medical implants
  • deposition methods

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Published Papers (1 paper)

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Research

12 pages, 3535 KB  
Article
TiN-Ag Multilayer Protective Coatings for Surface Modification of AISI 316 Stainless Steel Medical Implants
by Božana Petrović, Dijana Mitić, Minja Miličić Lazić, Miloš Lazarević, Anka Trajkovska Petkoska, Ilija Nasov, Slavoljub Živković and Vukoman Jokanović
Coatings 2025, 15(7), 820; https://doi.org/10.3390/coatings15070820 - 14 Jul 2025
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Abstract
Stainless steel (SS) is one of the materials most commonly utilized for fabrication of medical implants and its properties are often improved by deposition of protective coatings. This study investigates certain physico-chemical and biological properties of SS substrate coated with multilayer thin film [...] Read more.
Stainless steel (SS) is one of the materials most commonly utilized for fabrication of medical implants and its properties are often improved by deposition of protective coatings. This study investigates certain physico-chemical and biological properties of SS substrate coated with multilayer thin film consisting of titanium nitride and silver layers (TiN-Ag film). TiN-Ag films were deposited on the surface of AISI 316 SS substrate by a combination of cathodic arc evaporation and DC magnetron sputtering. SS substrate was analyzed by TEM, while deposited coatings were analyzed by SEM, EDS and wettability measurements. Also, mitochondrial activity assay, and osteogenic and chondrogenic differentiation were performed on dental pulp stem cells (DPSCs). SEM and EDS revealed excellent adhesion between coatings’ layers, with the top layer predominantly composed of Ag, which is responsible for antibacterial properties. TiN-Ag film exhibited moderately hydrophilic behaviour which is desirable for orthopedic implant applications. Biological assays revealed significantly higher mitochondrial activity and enhanced osteogenic and chondrogenic differentiation of DPSC on TiN-Ag films compared to TiN films. The newly designed TiN-Ag coatings showed a great potential for the surface modification of SS implants, and further detailed investigations will explore their suitability for application in clinical practice. Full article
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