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Antibacterial Coating in Biomedical Applications
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Antibacterial Coating in Biomedical Applications

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 8446

Special Issue Editors

Dr. Shiqiang Gong

E-Mail Website
Guest Editor
Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Interests: dental antibacterial materials; dentin bonding; multifunctional coating on implants; tissue engineering
Dr. Shengcai Qi

E-Mail Website
Guest Editor
School of Stomatology, Fudan University, Shanghai 201102, China
Interests: NRAGE; enamel hypoplasia; thyroid tumor; hepatitis; oral homeostasis; small molecule compounds; bone homeostasis; nanomaterials; periodontal disease; tissue regeneration
Dr. Ying Yang

E-Mail Website
Guest Editor
Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI 48109, USA
Interests: bioinspired coating; surface modification; biomedical devices; tissue engineering

Special Issue Information

Dear Colleagues,

Despite considerable progress in the development of nanobiotechnology and nanofabrication techniques, the quest to design and fabricate new antibacterial surfaces of advanced biomaterials remains a high research priority. It is well established that sessile microorganisms in biofilms are up to 1000 times more resistant to antibacterial agents compared to the same bacteria in planktonic status. Moreover, there are many non-absorbable materials implanted into the body in clinic. These materials used in clinic may be failed due to the infection by bacteria. The drug resistance caused by antibiotic abuse is an important problem that needs to be solved urgently in clinic. Using coating biotechnology to inhibit bacterial infection is helpful and meaningful. Recently, a great deal of effort has been devoted to designing a new generation of coatings with antibacterial functionality, in order to eliminate adverse effects of the biofilm on the function of a variety of specific bio-interfaces. This Special Issue will serve as a forum for papers reporting recent progress of antibacterial coating in the biomedical field in many clinical settings.

Dr. Shiqiang Gong
Dr. Shengcai Qi
Dr. Ying Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • self-cleaning
  • bacteria repelling
  • coating
  • antibacterial
  • antibiofouling
  • implant
  • infection
  • osteogenesis

Published Papers (4 papers)

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Research

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10 pages, 2726 KiB  
Article
Surface Modification of Titanium by Micro-Arc Oxidation in Promoting Schwann Cell Proliferation and Secretion of Neurotrophic Factors
by Cong Dong, Shenghao Xue, Binbin Kang, Xinyuan Zhang, Qun Zhong, Xiaohong Chen and Shengcai Qi
Coatings 2022, 12(12), 1797; https://doi.org/10.3390/coatings12121797 - 22 Nov 2022
Viewed by 1067
Abstract
Titanium and its alloys have been widely used in the field of oral implants over the past few decades. However, the effect of micro-arc oxidation modified titanium surface on Schwann cells has not been studied, which is of great significance for nerve regeneration [...] Read more.
Titanium and its alloys have been widely used in the field of oral implants over the past few decades. However, the effect of micro-arc oxidation modified titanium surface on Schwann cells has not been studied, which is of great significance for nerve regeneration around implants and improvement of osseoperception. In this study, the characterization of the titanium surface modified by micro-arc oxidation (MAO) was detected by scanning electron microscope (SEM), XPS and a contact angle measurement system. Schwann cells (SCs) were cultured on titanium surfaces of micro-arc oxidation (MAO) and pure titanium (Ti). At different time points, the morphology and adhesion of SCs on the titanium surfaces were observed by SEM. Cell proliferation activity was detected by the CCK-8 method. The expression levels of mRNA and proteins of nerve growth factor (NGF) and glial-derived neurotrophic factor (GDNF) were detected by RT-PCR, immunofluorescence and western blot. The results of this in vitro study revealed that micro-arc-oxidation-modified titanium surfaces promoted Schwann cell proliferation and secretion of neurotrophic factors compared with pure titanium. CCK-8 results showed that the number of Schwann cells on MAO surfaces was significantly higher than that of the Ti group on day 7. The mRNA expressions of Ngf and Gdnf were up-regulated in both groups from day 1 to day 7. On day 3 and day 7, the gene expression of Ngf in the MAO group was significantly higher than that of the Ti group. On day 7, the MAO group appeared significantly up-regulated in gene expression level of Gdnf. The results of western blot were consistent. Micro-arc oxidation modification provides an accurate and effective method for promoting nerve regeneration of titanium microtopography coatings, which have potential significance for promoting patients’ osseoperception ability in clinical practice. Full article
(This article belongs to the Special Issue Antibacterial Coating in Biomedical Applications)
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10 pages, 2629 KiB  
Article
Antibacterial Activity and Bioactivity of Zn-Doped TiO2 Coating for Implants
by Binbin Kang, Dongmei Lan, Lei Liu, Rui Dang, Chao Yao, Ping Liu, Fengcang Ma, Shengcai Qi and Xiaohong Chen
Coatings 2022, 12(9), 1264; https://doi.org/10.3390/coatings12091264 - 30 Aug 2022
Cited by 7 | Viewed by 1417
Abstract
Lacking osseointegration and peri-implantitis induced by bacterial infiltration are the pivotal issues for the long-term clinical success of implants. In order to improve the bioactivity and antibacterial properties of implant materials, volcano-shaped microporous TiO2 coatings doped with Zinc (Zn) were fabricated via [...] Read more.
Lacking osseointegration and peri-implantitis induced by bacterial infiltration are the pivotal issues for the long-term clinical success of implants. In order to improve the bioactivity and antibacterial properties of implant materials, volcano-shaped microporous TiO2 coatings doped with Zinc (Zn) were fabricated via a micro-arc oxidation (MAO) method on pure titanium (Ti). The microstructure, morphology, and chemical composition of the Zn-doped coatings were systematically studied. In cell culture tests, the formed coatings promoted the adhesion and proliferation of bone mesenchymal stem cells (BMSCs), exhibiting good biocompatibility. The antibacterial experiments revealed that Zn-TiO2 coatings possess excellent antibacterial properties against Staphylococcus aureus (S. aureus) and Porphyromonas gingivalis (P. gingivalis). Full article
(This article belongs to the Special Issue Antibacterial Coating in Biomedical Applications)
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13 pages, 2054 KiB  
Article
Calcium Phosphate Cement Promotes Odontoblastic Differentiation of Dental Pulp Cells In Vitro and In Vivo
by Haiyan Huang, Linjuan Luo, Lefeng Li, Yun Guan, Yanhong Yan, Zhen Jiang and Beizhan Jiang
Coatings 2022, 12(4), 543; https://doi.org/10.3390/coatings12040543 - 18 Apr 2022
Cited by 1 | Viewed by 2397
Abstract
In the case of pulp injury, odontoblastic differentiation of dental pulp cells (DPCs) at the site of the exposed pulp is necessary for a successful direct pulp capping treatment. Calcium phosphate cement (CPC), a kind of hydroxyapatite-like bone cement, exhibits therapeutic potential in [...] Read more.
In the case of pulp injury, odontoblastic differentiation of dental pulp cells (DPCs) at the site of the exposed pulp is necessary for a successful direct pulp capping treatment. Calcium phosphate cement (CPC), a kind of hydroxyapatite-like bone cement, exhibits therapeutic potential in osteogenesis by regulating cell cycle progression and promoting osteoblastic differentiation. Based on the similar biological process of osteo/odontoblastic differentiation, the present study evaluated the effects of CPC on odontoblastic differentiation of DPCs in vitro and in vivo, respectively. The morphology of CPC was observed by scanning electron microscopy. Colony-forming units were used to assess the antibacterial activity. The effects of CPC on cell proliferation and odontoblastic differentiation of human dental pulp cells (hDPCs) were also measured. Histological staining was performed to observe the reparative dentin formation in rat molars. In vitro, results of antibacterial studies showed that CPC significantly inhibited the growth of Streptococcus mutans. The appropriate concentration of CPC extract showed low cytotoxicity on hDPCs. Furthermore, CPC extract also promoted odontoblastic differentiation and mineralization compared with the control group, as shown by a dynamic increase in the expression of odontogenic marker genes and the increased number of mineralized nodules at 21 days. The pulpotomy models with CPC facilitated the formation of dentin bridge with the highly expressed dentin matrix protein 1 (DMP1) in odontoblast-like cells. In conclusion, the favorable biocompatibility, antibacterial property and bio-inductivity of CPC suggest that CPC can be used as a promising direct pulp capping material. Full article
(This article belongs to the Special Issue Antibacterial Coating in Biomedical Applications)
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Review

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17 pages, 880 KiB  
Review
Influence of Dental Implant Surface Modifications on Osseointegration and Biofilm Attachment
by Wen Han, Shuobo Fang, Qun Zhong and Shengcai Qi
Coatings 2022, 12(11), 1654; https://doi.org/10.3390/coatings12111654 - 31 Oct 2022
Cited by 5 | Viewed by 2944
Abstract
Dental implants have been widely applied in partially and fully edentulous patients and have shown predictable clinical outcomes, but there are still many cases of implant failures, such as osseointegration failure and peri-implant inflammation. To improve the success rate of implants, especially in [...] Read more.
Dental implants have been widely applied in partially and fully edentulous patients and have shown predictable clinical outcomes, but there are still many cases of implant failures, such as osseointegration failure and peri-implant inflammation. To improve the success rate of implants, especially in improving osseointegration and antibacterial performance, various methods of implant surface modification have been applied. Surface modification methods covered include sandblasting with large-grit corundum and acid etched (SLA), plasma spraying, plasma immersion ion implantation (PIII), sputter-deposition, selective laser melting (SLM), anodic oxidation, microarc oxidation, sol-gel coating, alkaline heat treatment (AH) and Layer-by-Layer (LBL) self-assembly. This review comprehensively summarizes the influence of each method on osseointegration and biofilm attachment. The mechanical, chemical and biological disadvantages of these methods are involved. Besides, the mechanisms behind such techniques as increasing surface roughness to expand superficial area and enhance the adhesion of osteoblastic cells are discussed. Full article
(This article belongs to the Special Issue Antibacterial Coating in Biomedical Applications)
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