Polymorphism in Crystals (2nd Edition)

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Crystal Engineering".

Deadline for manuscript submissions: 15 March 2025 | Viewed by 149

Special Issue Editor

National Engineering Research Center of Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
Interests: polymorph; crystal engineering; functional crystal material
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymorphism, the property of a compound to crystallize in more than one distinct crystal form, plays an indispensable role in researching and developing pharmaceuticals, agrochemicals, materials, and food. Polymorphs exhibit different properties, such as crystal habit, solubility, dissolution rate, melting point, stability, mechanical properties, and even bioavailability, which may influence product quality. Therefore, studying polymorph behavior can provide a theoretical basis for selecting optimal solid forms and aid in the polymorphic control and optimization of products. Recently, significant progress has been made in the experimental discovery and theoretical prediction of crystal polymorphs. Indeed, many molecules have been discovered to have polymorphs, mainly attributed to the molecule’s conformational flexibility and the existence of various functionalities allowing the molecule to act as a hydrogen bond donor/acceptor. In addition to conventional solution crystallization, more polymorphisms have been found in melt, confinement, and the presence of ultrasound/lasers.

Moreover, computational predictions usually yield far more possible polymorphs than are known. The ultimate limitations of experimentally reachable polymorphs and their thermodynamical and structure–activity relationships remain an open question. The present Special Issue on “Polymorphism in Crystals” invites status reports summarizing the progress achieved in recent years.

Dr. Xin Huang
Guest Editor

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Keywords

  • polymorphism
  • crystal engineering
  • crystal habit

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