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Crystals
Special Issues
Advances in Pharmaceutical Crystallization
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Advances in Pharmaceutical Crystallization

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Crystal Engineering".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 2947

Special Issue Editors

Dr. Rupanjali Prasad

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Guest Editor
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
Interests: crystallization; polymorphism; morphology; process analytical technology; spectroscopy; molecular dynamics simulations
Dr. Ayse Eren

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Guest Editor
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Interests: crystallization; process systems engineering; process modeling and optimization; process analytical technology; macromolecule manufacturing; polymorphism
Prof. Dr. Zoltan Nagy

E-Mail Website
Guest Editor
Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA
Interests: crystallization systems engineering; control for intelligent manufacturing systems of particulates; process analytical technologies and composite sensor arrays

Special Issue Information

Dear Colleagues,

We are delighted to invite you to submit an article for a Special Issue of Crystals titled “Advances in Pharmaceutical Crystallization”.

Crystallization is widely used in the pharmaceutical industry for the production of drug substances as well as for purification and separation to obtain good-quality crystals. Controlling the critical quality attributes (CQAs) such as crystal size, size distribution, morphology, purity, chirality, and form is very crucial during pharmaceutical crystallization as the CQAs not only affect the downstream processes such as filtration, drying, or milling, but also influence the drug’s solubility, dissolution rate, and, therefore, its bioavailability. This Special Issue is intended to highlight recent breakthroughs in the field of pharmaceutical crystallization for better control of such crystal attributes. Papers related to experimental studies, theory, and simulations that contribute to the fundamental understanding of single or multicomponent crystallization are highly encouraged. The range of topics encompasses, but is not limited to:

  1. Online process analytical technology (PAT) such as ATR-FTIR, Raman, NIR, UV-Vis, FBRM, PVM, etc., for controlling CQAs.
  2. Novel quality-by-design (QbD) or quality-by-control (QbC) approaches for process control.
  3. Addressing scale-up challenges (such as mixing, secondary nucleation, etc.).
  4. Scale-up/scale-down process development of batch, semi-batch, or continuous crystallization using experimental or simulation/modelling tools (CFD, Dynochem, gPROMS, etc.).
  5. Purification of solid solutions and impurity rejection during crystallization.
  6. Theoretical advancements in solubility prediction models and predicting the effect of impurity on solubility.
  7. Application of data analytics, artificial intelligence, and machine learning methods in crystallization.
  8. Crystallization of macromolecules (e.g., proteins, monoclonal antibodies, RNAs).

Dr. Rupanjali Prasad
Dr. Ayse Eren
Prof. Dr. Zoltan Nagy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nucleation
  • crystallization
  • process control
  • process systems engineering
  • process analytical technology
  • polymorphism
  • continuous manufacturing
  • process development
  • machine learning
  • kinetic modeling

Published Papers (2 papers)

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Research

15 pages, 5266 KiB  
Article
Solubility and Crystallization of Glucosamine Hydrochloride in Water with the Presence of Additives
by Zhiying Pan, Yan Wang, Yang Xie, Jie Tan, Qian Zhang, Jianxing Lu, Shichao Du and Fumin Xue
Crystals 2023, 13(9), 1326; https://doi.org/10.3390/cryst13091326 - 30 Aug 2023
Cited by 1 | Viewed by 1299
Abstract
Glucosamine hydrochloride (GAH) is a kind of natural hexose, which is used to promote the synthesis of mucopolysaccharides and improve the metabolism of articular cartilage. In this paper, the solubility of GAH in pure water and aqueous system with the presence of three [...] Read more.
Glucosamine hydrochloride (GAH) is a kind of natural hexose, which is used to promote the synthesis of mucopolysaccharides and improve the metabolism of articular cartilage. In this paper, the solubility of GAH in pure water and aqueous system with the presence of three kinds of additives (HCl, NaCl, KCl) at temperatures ranging from 278.15 K to 323.15 K was determined by gravimetric method. When there are additives in water, the solubility of GAH increases with the increase of temperature and decreases with the increase of concentration of the three kinds of additives. When the additives were at similar mole fractions, HCl led to the lowest solubility of GAH. The modified Apelblat model and van’t Hoff model were used to correlate the solubility data. The average relative deviation (ARD) data of Apelblat and van’t Hoff models were less than 5%, indicating good fitting results. Based on the thermodynamic data, the cooling crystallization process of GAH was performed. It was found that the additives could affect the crystal morphology, particle size, and yield of GAH products. This study supplemented the thermodynamic data of GAH and studied the cooling crystallization process in the presence of GAH additives, which provided important guidance for the optimization of the crystallization process. Full article
(This article belongs to the Special Issue Advances in Pharmaceutical Crystallization)
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0 pages, 5947 KiB  
Article
pH-Dependent Crystallization of 2-, 4-, 5-, and 6-Hydroxynicotinic Acids in Aqueous Media
by Aidan V. Johnson, M. Fátima M. Piedade and Catarina V. Esteves
Crystals 2023, 13(7), 1062; https://doi.org/10.3390/cryst13071062 - 5 Jul 2023
Viewed by 1163
Abstract
2-, 4-, 5-, and 6-hydroxynicotinic acids were crystallized in a pH-dependent manner using only water as the preferred solvent. The crystallization outcome was quite diverse: individual crystals of different sizes and shapes, microcrystalline powders, crystalline aggregates, and almost amorphous solids. Such a variety [...] Read more.
2-, 4-, 5-, and 6-hydroxynicotinic acids were crystallized in a pH-dependent manner using only water as the preferred solvent. The crystallization outcome was quite diverse: individual crystals of different sizes and shapes, microcrystalline powders, crystalline aggregates, and almost amorphous solids. Such a variety of solid forms demonstrates the relevance of pH control during crystallization processes. Full article
(This article belongs to the Special Issue Advances in Pharmaceutical Crystallization)
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