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Dentistry Journal
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Considering Host-Biomaterials and Microbial Interactions in Oral Health and Their...
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Considering Host-Biomaterials and Microbial Interactions in Oral Health and Their Impact on the Development of Dental Material

A special issue of Dentistry Journal (ISSN 2304-6767). This special issue belongs to the section "Dental Materials".

Deadline for manuscript submissions: closed (22 May 2023) | Viewed by 14041

Special Issue Editor

Prof. Dr. Yoav Finer

E-Mail Website
Guest Editor
1. Faculty of Dentistry and Institute of Biomedical Engineering, University of Toronto, 124 Edward Street, Toronto, ON M5G 1G6, Canada
2. Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada
Interests: biomaterials; prosthodontics; host–biomaterials and –microbial interactions

Special Issue Information

Dear Colleagues,

Traditional dental material developments have focused on physical and mechanical properties. However, dental materials are not inert and interact with the host and oral bacteria. The effect of host and microbial degradative activities on the materials and the tooth, and the impact on oral health, as well as the reciprocal effect of the materials and the material’s by-products on the host and bacteria, will be the focus of this Special Issue. Recent developments in addressing the above challenges by developing testing methods that consider the host–biomaterials and –microbial interactions and challenges, and the development of innovative restorative, endodontic and implant coating biomaterials that are resistant to host and microbial degradation and/or actively counteracting these activities and modulating microbial and host response to the materials, will be covered in this Special Issue. We are welcoming relevant original studies, systematic and narrative reviews related to host-biomaterials and microbial interactions on oral health, and the development of innovative dental biomaterials that consider these interactions for this Special Issue. All submissions will be subject to a rigorous review process, as are submissions to the regular issues of Dentistry Journal.

Sincerely,

Yoav Finer, DMD, PhD, FRCD(C), George Zarb Nobel-Biocare Chair in Prosthodontic

Faculty of Dentistry, Institute of Biomedical Engineering, University of Toronto

Prof. Dr. Yoav Finer

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral health
  • dental biomaterials
  • dental restoration performance
  • host–biomaterial and –microbial interactions
  • biodegradation
  • enzyme
  • oral bacteria
  • immune system
  • restorative dentistry
  • dental implants
  • endodontics

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Published Papers (3 papers)

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13 pages, 1417 KiB  
Article
An In Vivo Study on the Development of Bacterial Microbiome on Clear Orthodontic Retainer
by Kabilan Velliyagounder, Anil Ardeshna and Serena Shah
Dent. J. 2022, 10(12), 239; https://doi.org/10.3390/dj10120239 - 16 Dec 2022
Viewed by 2554
Abstract
Objectives: The objective of this study was to see how the bacterial composition changes on clear orthodontic retainer over a 14-day period. Methods: Saliva and plaque samples collected from a clear retainer surface were obtained from five healthy volunteers receiving retainer treatment. Prior [...] Read more.
Objectives: The objective of this study was to see how the bacterial composition changes on clear orthodontic retainer over a 14-day period. Methods: Saliva and plaque samples collected from a clear retainer surface were obtained from five healthy volunteers receiving retainer treatment. Prior to clear retainer delivery, patients had not been wearing any other appliances. Patients were instructed to wear their clear retainer for the 14-day period, taking them off to eat and to clean them with a soft-bristle toothbrush. The bacterial composition was determined via Illumina MiSeq sequencing of the bacterial 16S rRNA. After bioinformatics processing using the QIIME pipeline, the intra- and intergroup biodiversity of the sample was analyzed. Results: The bacterial composition changed over a 14-day period in the saliva and on the clear retainer. When comparing the different phylum levels between saliva and clear retainer’ microbiota, the Firmicutes were significantly increased 1.26-fold (p = 0.0194) and 1.34-fold (p = 0.0123) after 7 and 14 days of retainer treatment when compared to saliva, respectively. The Campylobacteriota were significantly decreased 1.80-fold (p = 0.05) in the clear retainer when compared to saliva at 7 days. At the genus level, several microbiota were significantly increased in relative abundance in the clear retainer after the 14-day period. Conclusion: These findings reveal that the presence of a clear retainer in the mouth might lead to enamel changes or periodontal tissue destruction, especially after 14 days of use. Full article
(This article belongs to the Special Issue Considering Host-Biomaterials and Microbial Interactions in Oral Health and Their Impact on the Development of Dental Material)
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15 pages, 3575 KiB  
Article
Improper Light Curing of Bulkfill Composite Drives Surface Changes and Increases S. mutans Biofilm Growth as a Pathway for Higher Risk of Recurrent Caries around Restorations
by Haifa Maktabi, Maria Salem Ibrahim, Abdulrahman A. Balhaddad, Qoot Alkhubaizi, Isadora Martini Garcia, Fabrício Mezzomo Collares, Howard Strassler, Ana Paula P. Fugolin, Carmem S. Pfeifer and Mary Anne S. Melo
Dent. J. 2021, 9(8), 83; https://doi.org/10.3390/dj9080083 - 30 Jul 2021
Cited by 17 | Viewed by 3946
Abstract
How dentists cure a resin-based material has deleterious effects on the material’s properties and its interaction with surrounding dental tissues. Biofilm accumulation has been implicated in the pathogenesis of carious lesions around dental restorations, with its composition manifesting expressed dysbiosis in patients suffering [...] Read more.
How dentists cure a resin-based material has deleterious effects on the material’s properties and its interaction with surrounding dental tissues. Biofilm accumulation has been implicated in the pathogenesis of carious lesions around dental restorations, with its composition manifesting expressed dysbiosis in patients suffering from dental caries. To evaluate the influence of varying radiant exposure on the degree of conversion (DC%), Streptococcus mutans biofilm growth, and surface roughness of bulk-fill composites under different light-curing conditions. Two light-curing units (LCU) at 600 and 1000 mW/cm2 were used to simulate curing conditions with different angulations (∢20° and ∢35°) or 2 mm-distance displacements of the LCU tip. The radiant exposure (RE) was assessed, and the composites were analyzed for DC%. Biofilm formation was induced over the bulk-fill composites and analyzed via colony-forming units counting and scanning electron microscopy (SEM). The surface roughness was analyzed via a profilometer and SEM after biofilm formation. Curing conditions with different angulation or displacement decreased RE compared to the “optimal condition”. The moderately (∢35°) angulated LCU tip and low (600 mW/cm2) radiant emittance significantly reduced the DC% (p < 0.05). The difference in DC% between the top and bottom of the composites ranged from 8 to 11% for 600 mW/cm2 and 10 to 20% for 1000 mW/cm2. Greater S. mutans biofilm and surface changes were found in composites with non-optimal RE delivery (e.g., tip displacement and angulation) (p < 0.05). Inadequate polymerization of bulk-fill composites was associated with more biofilm accumulation and surface topography changes. Overall, non-optimally performed curing procedures reduced the amount of delivered RE, which led to low DC%, more biofilm formation, and higher surface roughness. The improper light-curing of bulk-fill composites compromises their physicochemical and biological properties, which could lead to inferior clinical performance and reduced restorative treatments’ longevity. Full article
(This article belongs to the Special Issue Considering Host-Biomaterials and Microbial Interactions in Oral Health and Their Impact on the Development of Dental Material)
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13 pages, 47145 KiB  
Project Report
Streptococcus mutans Proteases Degrade Dentinal Collagen
by Bo Huang, Cameron A. Stewart, Christopher A. McCulloch, J. Paul Santerre, Dennis G. Cvitkovitch and Yoav Finer
Dent. J. 2022, 10(12), 223; https://doi.org/10.3390/dj10120223 - 28 Nov 2022
Cited by 7 | Viewed by 6468
Abstract
Here, we explored the role of S. mutans’s whole cell and discrete fractions in the degradation of type I collagen and dentinal collagen. Type I collagen gels and human demineralized dentin slabs (DS) were incubated in media alone or with one of [...] Read more.
Here, we explored the role of S. mutans’s whole cell and discrete fractions in the degradation of type I collagen and dentinal collagen. Type I collagen gels and human demineralized dentin slabs (DS) were incubated in media alone or with one of the following: overnight (O/N) or newly inoculated (NEW) cultures of S. mutans UA159; intracellular proteins, supernatant or bacterial membranes of O/N cultures. Media from all groups were analyzed for protease-mediated release of the collagen-specific imino acid hydroxyproline. Images of type I collagen and DS were analyzed, respectively. Type I collagen degradation was highest for the supernatant (p < 0.05) fractions, followed by intracellular components and O/N cultures. Collagen degradation for DS samples was highest for O/N samples, followed by supernatant, and intracellular components (p < 0.05). There was lower detectable degradation for both type I collagen and DS from NEW culture samples (p < 0.05), and there was no type I collagen or DS degradation detected for bacterial membrane samples. Structural changes to type I collagen gel and dentinal collagen were observed, respectively, following incubation with S. mutans cultures (O/N and NEW), intracellular components, and supernatant. This study demonstrates that intracellular and extracellular proteolytic activities from S. mutans enable this cariogenic bacterium to degrade type I and dentinal collagen in a growth-phase dependent manner, potentially contributing to the progression of dental caries. Full article
(This article belongs to the Special Issue Considering Host-Biomaterials and Microbial Interactions in Oral Health and Their Impact on the Development of Dental Material)
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