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Diabetology
Special Issues
New Perspectives on Diabetes and Stroke Research
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New Perspectives on Diabetes and Stroke Research

A special issue of Diabetology (ISSN 2673-4540).

Deadline for manuscript submissions: 15 October 2026 | Viewed by 2942

Special Issue Editors

Dr. Rashmi Kumari

E-Mail Website
Guest Editor
Department of Neuroscience and Experimental Therapeutics, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
Interests: diabetes mellitus; stroke; db mouse; diabetic mice; myocardial ischemia reperfus; hypoxia–ischemia; metabolic disorders; vascular permeability
Special Issues, Collections and Topics in MDPI journals
Dr. Siddharth Sunilkumar

E-Mail Website
Guest Editor
Department of Cell and Biological Systems, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Interests: diabetes complications; cell signaling; membrane trafficking

Special Issue Information

Dear Colleagues,

We would like to invite you to submit your research or perspective opinion in the upcoming Special Issue “New Perspectives on Diabetes and Stroke Research” in the reputed journal Diabetology by the MDPI publishing group. It is established that the metabolic dysregulation in diabetes plays an important role in the development of stroke and its recovery. The other important factor is considering subclinical inflammation in diabetics, which causes immune dysregulation and changes in vascular characteristics, as well as leads to dementia and cognitive impairment in the elderly population. Diabetes is a global health crisis, and its complications, such as stroke, pose a tremendous challenge to the family and healthcare system. Therefore, in the Special Issue, we would like to summarize the collective approach, thoughts, and successes that have been achieved in the area of research.

 We would like you to consider submitting an original research (basic science or clinical), a review on a new perspective in the treatment strategy, or challenges in the implementation of established treatment. The collective approach will be helpful for the research community to explore not only finding a cure for the devastating disease of stroke but also to apply the knowledge to other research related to vascular diseases.  This will be advantageous for the physician scientists, who take care of the elderly stroke patients. Thank you in advance for your time and consideration to share your research/ thoughts in this Special Issue. It would be much appreciated if you could accept our invitation. 

Looking forward to hearing back from you.

Dr. Rashmi Kumari
Dr. Siddharth Sunilkumar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diabetology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes
  • ischemic stroke
  • blood–brain barrier
  • inflammation
  • vascular remodeling
  • cognitive impairment
  • hyperglycemia
  • diabetic mouse model

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

20 pages, 348 KB  
Review
The Role of Obstructive Sleep Apnea and Diabetes Mellitus in the Development of Cerebrovascular Complications: A Narrative Review
by Ron T. Varghese, Isabella A. Sharifi, Ugur D. Ayar, Samuele F. Petridis, Sneha Akurati, Ernesto Bernal-Mizrachi and Naresh Punjabi
Diabetology 2026, 7(3), 60; https://doi.org/10.3390/diabetology7030060 - 16 Mar 2026
Cited by 1 | Viewed by 1058
Abstract
Background: Cerebrovascular accidents (stroke) remain a leading global cause of death and disability, with its burden increasingly overlapping the rising prevalence of obstructive sleep apnea (OSA) and diabetes mellitus (DM). These highly prevalent cardiometabolic conditions frequently coexist and may jointly amplify cerebrovascular risk [...] Read more.
Background: Cerebrovascular accidents (stroke) remain a leading global cause of death and disability, with its burden increasingly overlapping the rising prevalence of obstructive sleep apnea (OSA) and diabetes mellitus (DM). These highly prevalent cardiometabolic conditions frequently coexist and may jointly amplify cerebrovascular risk through shared and interacting pathophysiologic pathways. This narrative review synthesizes current evidence on the independent and combined contributions of OSA and DM to cerebrovascular complications, with emphasis on mechanisms, stroke outcomes and implications for screening and integrated management. Methods: A narrative review was conducted using PubMed, MEDLINE, and the Cochrane Library to identify English-language articles published between January 2000 and December 2024. Search terms combined OSA or sleep-disordered breathing with stroke or cerebrovascular disease and DM or hyperglycemia. Secondary searches targeted mechanistic domains including intermittent hypoxia, insulin resistance, metabolic syndrome, atrial fibrillation, hypercoagulability, and bariatric surgery. Priority was given to systematic reviews and meta-analyses, randomized controlled trials, and large prospective cohort studies, with smaller studies included when mechanistically informative. Findings were synthesized thematically across OSA-related mechanisms, DM-related mechanisms, bidirectional interactions, combined risk through metabolic syndrome, stroke outcomes, and clinical management considerations. Results: OSA is associated with increased cerebrovascular risk through intermittent hypoxemia-related oxidative stress and inflammation, sympathetic activation with blood pressure surges and sustained hypertension, endothelial dysfunction and atherosclerosis, impaired cerebral autoregulation, arrhythmogenesis, particularly atrial fibrillation and prothrombotic changes. DM increases stroke risk via accelerated atherosclerosis, cerebral small vessel disease, endothelial injury, hypercoagulability, glycemic variability, and cardioembolic mechanisms. Evidence indicates that coexisting OSA and DM are common and associated with greater vascular injury markers, higher rates of cerebrovascular events, and poorer post-stroke recovery. Conclusions: OSA and DM contribute to cerebrovascular complications through convergent mechanisms centered on metabolic syndrome, obesity, inflammation, vascular dysfunction, and thrombosis. These findings support proactive screening and coordinated management strategies to reduce cerebrovascular risk and improve outcomes. Full article
(This article belongs to the Special Issue New Perspectives on Diabetes and Stroke Research)
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Graphical abstract

24 pages, 1139 KB  
Review
SLC35 Transporters: The Missing Link Between Glycosylation and Type 2 Diabetes
by Xu Zhang, Hafiza Mahreen Mehwish and Pulin Che
Diabetology 2026, 7(1), 7; https://doi.org/10.3390/diabetology7010007 - 1 Jan 2026
Viewed by 1328
Abstract
Type 2 diabetes mellitus (T2D) affects hundreds of millions worldwide, with recent estimates indicating approximately 589 million adults living with diabetes, most with type 2 disease. Beyond classical insulin signaling pathways, increasing evidence implicates altered protein glycosylation in metabolic dysfunction. The solute carrier [...] Read more.
Type 2 diabetes mellitus (T2D) affects hundreds of millions worldwide, with recent estimates indicating approximately 589 million adults living with diabetes, most with type 2 disease. Beyond classical insulin signaling pathways, increasing evidence implicates altered protein glycosylation in metabolic dysfunction. The solute carrier 35 (SLC35) family of nucleotide sugar transporters mediates the import of activated sugars into the endoplasmic reticulum and Golgi lumen, thereby influencing global glycosylation patterns. Dysregulation of these transporters can perturb glucose homeostasis, insulin responsiveness, and nutrient-sensing pathways through changes in glycosylation flux. In this review, we dissect the molecular mechanisms by which these transporters modulate glucose homeostasis, insulin signaling pathways, protein O-GlcN acylation, and broader glycosylation processes. We integrate findings from human genetic studies, rodent models, and in vitro functional analyses to characterize how altered SLC35 activity is associated with T2D and metabolic syndrome. Four members demonstrate particularly compelling evidence: SLC35B4 modulates hepatic glucose metabolism, SLC35D3 mutations impair dopaminergic signaling and energy balance, and SLC35F3 variants interact with high-carbohydrate intake to increase metabolic-syndrome risk. SLC35A3, though less studied, may influence glycosylation-dependent insulin signaling through its role in N-glycan biosynthesis. Beyond these characterized transporters, this review identifies potential metabolic roles for understudied family members, suggesting broader implications across the entire SLC35 family. We also discuss how such alterations can lead to disrupted hexosamine flux, impaired glycoprotein processing, aberrant cellular signaling, and micronutrient imbalances. Finally, we evaluate the therapeutic potential of targeting SLC35 transporters, outlining both opportunities and challenges in translating these insights into novel T2D treatments. Full article
(This article belongs to the Special Issue New Perspectives on Diabetes and Stroke Research)
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