Optimization and Analysis of the Fermentation Process for Microbial Products: 2nd Edition

Dear Colleagues,

Fermentation process optimization refers to the improvement of the production, productivity, and conversion rate of target metabolites in the fermenter through the control of operating conditions on the basis of the obtained high-yield strain. The fermentation process is usually carried out in a specific reactor. Since the microbial reaction is a self-catalytic reaction, the microbial cell itself is also a reactor, and all the substances to come out of the microreactor of the cell must pass through the boundary line between the cell and the environment, so that all reactions that occur in the cell (i.e., the biological phase) are closely linked to the environmental condition (i.e., the abiotic phase). The actual biological reaction system is a very complex three-phase system, that is, a mixture of gas, liquid, and solid phases, and the concentration gradient between the three phases varies greatly by several orders of magnitude. Therefore, to optimize such a complex system, an elaborate analysis and study of the fermentation process must be carried out. This Special Issue covers topics such as the following:

• Improvement of the producing strains by irrationality and rationality methods;
• Design and optimization of fermentation media;
• The optimization and control of the fermentation process to maximize production or minimize costs;
• Analyses of the improvement of fermentation process optimization by physiology and omics.

The aim of this Special Issue is to publish both recent innovative research results as well as review papers on the optimization and analysis of fermentation processes for microbial products.

Sincerely,

Dr. Xidong Ren
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• process optimization
• integrated fermentation
• technoeconomic analysis
• artificial intelligence
• artificial neural network
• factorial designs
• genomics
• transcriptomics
• proteomics
• metabolomics