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Gels
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Advanced Hydrogels for Tissue Engineering and Drug Delivery (2nd Edition)
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Advanced Hydrogels for Tissue Engineering and Drug Delivery (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 15 March 2025 | Viewed by 3090

Special Issue Editor

Dr. Jin-Oh Jeong

E-Mail Website
Guest Editor
Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Interests: biomaterials; tissue engineering; biomaterial engineering; biocompatibility; biodegradable polymers; biopolymers; stem cell differentiation; biomechanical engineering; material characterization; bone regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hydrogel is a three-dimensional network structure with a polymer chain bonded through covalent and/or secondary bonds, which enables strong hydrogen bonding with water molecules. Hydrogel can contain drugs, cells, and a large amount of water which, when in contact with water, can cause substantial swelling. Hydrogel can also be degraded through tissue engineering by using the crosslinking method.

This Special Issue on “Advanced Hydrogels for Tissue Engineering and Drug Delivery” covers the theory of biopolymers for hydrogel fabrication, an introduction to various methods for hydrogel fabrication, drug loading/release effects, and recent developments in tissue engineering applications. Research on tissue engineering and the drug delivery of hydrogels has attracted considerable interest in the past decades. Recently, research has been conducted on controlling drug release and tissue engineering applications through various methods, such as electrical/physical stimulation, biofunctional modification for targeting/sustained release, and cell encapsulation. This Special Issue welcomes contributions on application of the methodology and fabrication of different types of hydrogels for effective drug delivery and tissue engineering.

Dr. Jin-Oh Jeong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterial
  • hydrogel
  • tissue engineering
  • smart drug delivery
  • biopolymers

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Related Special Issue

Published Papers (2 papers)

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Research

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15 pages, 20120 KiB  
Article
Composite Polysaccharide Hydrogel Loaded with Scutellaria baicalensis Extract for Diabetic Wound Treatment
by Yumeng Zhu, Fangyan Li, Shuo Wang, Hongmei Shi, Minqian Zhao, Shaohong You, Sibo Su and Gang Cheng
Gels 2024, 10(9), 605; https://doi.org/10.3390/gels10090605 - 23 Sep 2024
Viewed by 765
Abstract
Diabetic wounds present significant burdens to both patients and the healthcare system due to their prolonged inflammatory phase and adverse microenvironment. Traditional Chinese medicine (TCM), particularly Scutellaria baicalensis extract (SE), has shown promise in wound healing. Herein, sesbania gum (SG) was oxidized and [...] Read more.
Diabetic wounds present significant burdens to both patients and the healthcare system due to their prolonged inflammatory phase and adverse microenvironment. Traditional Chinese medicine (TCM), particularly Scutellaria baicalensis extract (SE), has shown promise in wound healing. Herein, sesbania gum (SG) was oxidized and formed hydrogel with carboxymethyl chitosan (CMCS) through the imine bond. Then, SE was loaded into the hydrogel as a wound dressing (CMCS−OSG@SE hydrogel). In vitro experiments demonstrated the mechanical properties and ROS scavenging efficiency of the hydrogel, as well as the release of SE and its biocompatibility. In an vivo study, diabetic mice with S. aureus infection were used, and the CMCS−-OSG@SE hydrogel dressing accelerated wound healing by promoting epidermal regeneration and collagen deposition. This composite polysaccharide hydrogel loaded with SE shows great potential for diabetic wound treatment. Full article
(This article belongs to the Special Issue Advanced Hydrogels for Tissue Engineering and Drug Delivery (2nd Edition))
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Review

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23 pages, 989 KiB  
Review
A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials
by Hoon Choi, Wan-Sun Choi and Jin-Oh Jeong
Gels 2024, 10(11), 693; https://doi.org/10.3390/gels10110693 - 25 Oct 2024
Viewed by 2142
Abstract
Hydrogels are known for their high water retention capacity and biocompatibility and have become essential materials in tissue engineering and drug delivery systems. This review explores recent advancements in hydrogel technology, focusing on innovative types such as self-healing, tough, smart, and hybrid hydrogels, [...] Read more.
Hydrogels are known for their high water retention capacity and biocompatibility and have become essential materials in tissue engineering and drug delivery systems. This review explores recent advancements in hydrogel technology, focusing on innovative types such as self-healing, tough, smart, and hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited for applications in dynamic biomedical environments. Tough hydrogels are designed with enhanced mechanical properties, enabling their use in load-bearing applications such as cartilage regeneration. Smart hydrogels respond to external stimuli, including changes in pH, temperature, and electromagnetic fields, making them ideal for controlled drug release tailored to specific medical needs. Hybrid hydrogels, made from both natural and synthetic polymers, combine bioactivity and mechanical resilience, which is particularly valuable in engineering complex tissues. Despite these innovations, challenges such as optimizing biocompatibility, adjusting degradation rates, and scaling up production remain. This review provides an in-depth analysis of these emerging hydrogel technologies, highlighting their transformative potential in both tissue engineering and drug delivery while outlining future directions for their development in biomedical applications. Full article
(This article belongs to the Special Issue Advanced Hydrogels for Tissue Engineering and Drug Delivery (2nd Edition))
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