Epigenetic and Genetic Instability in Cancer: From Basic Mechanisms to Translational and Clinical Applications
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (25 November 2023) | Viewed by 3986
Special Issue Editors
Interests: oxidative stress; NADPH oxidases; epi/genetic instability; cancer; biomarker
Interests: humoral immunity; immunoglobulin genes; B cell biology; B lymphomagenesis; DNA repair; mutagenesis; TLS polymerases; epigenetic and cell cycle
Special Issues, Collections and Topics in MDPI journals
Interests: DNA replication; DNA repair; epigenetic stability; cancer metabolism; programmed DNA elimination
Interests: DNA repair; epigenetic maintenance; transcription; genotoxic stress; oxidative stress; mitochondiral metabolism; fanconi anemia; breast cancer
Special Issue Information
Dear Colleagues,
Cancer, a real worldwide public health problem, is a multifactorial disease sharing both epigenetic and genetic instability. Deciphering molecular mechanisms that could initiate and promote these instabilities is of great interest in the aim to improve our knowledge regarding cellular transformation as well as translational and clinical applications.
Therefore, we are pleased to invite you to contribute to this Special Issue on ‘Epigenetic and Genetic Instability in Cancer: From Basic Mechanisms to Translational and Clinical Applications’.
In this Special Issue, we seek original research, review, mini-review, hypothesis and theory, clinical trial and opinion articles that cover but are not limited to the following subjects:- Understanding the molecular mechanisms of epigenetic instability in cancer: DNA methylation, microRNA, histone modifications;
- Understanding the molecular mechanisms of genetic instability in cancer: DNA damage signaling and DNA repair proteins, oncogenes, tumor suppressors;
- Spatiotemporal dynamics of chromatin in cancer;
- Epigenetics and associated mechanisms that alter chromatin in response to physiological or pathological signals;
- Genome editing technology in cancer;
- Methods of detection/analysis of genetic and epigenetic instability in cancer;
- Genetic and epigenetic biomarkers: identification approaches and clinical use.
Prof. Dr. Rabii Ameziane El Hassani
Dr. Said Aoufouchi
Dr. Leticia Lerner
Dr. Xavier Renaudin
Guest Editors
Manuscript Submission Information
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Keywords
- cancer
- (epi)genetic instability
- DNA repair
- chromatin remodeling
- (epi)mutations
- (epi)genome editing
- diagnostic and prognostic biomarkers
- chromatin-modifying enzymes
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