DNA Repair Immunity and Cancer

Dear Colleagues,

Intrinsic and extrinsic DNA damage constantly challenge the genome integrity of cells and organisms. To address these threats, cells have repair machinery that constantly and meticulously ensures and maintains genomic stability and activates immune responses that target and eliminate those cells.

It is widely accepted that repair deficiency is associated with increased cancer risk and that immunodeficiency is an important risk factor for many cancers. B lymphocytes, on the contrary, use DNA repair factors to ensure the maturation of the humoral immune response through both somatic hypermutation and class switch recombination of immunoglobulin genes.

In this SI, we aim to gather a series of articles (original research, reviews, mini-reviews, hypotheses and theories, clinical trials, and opinions) that address those outstanding questions and others related to the role of DNA repair and the immune system individually and in collaboration in the maintenance of genomic stability and in cancer healthcare.

We are particularly interested in research examining, but not limited to, the following subjects:

• Temporal and spatial regulation of DNA repair factors and mechanisms;
• Immunoglobulin gene diversifications: physiology and B-cell neoplasia;
• How cancer cells can escape this immune surveillance and promote tumor progression.

Dr. Said Aoufouchi
Dr. Barbara Bertocci
Dr. Sophie Peron
Guest Editors

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• humoral immunity
• immunoglobulin gene diversification
• B cell biology
• B lymphomagenesis
• DNA repair
• mutagenesis
• TLS polymerases
• epigenetic and cell cycle