Advances in Nervous System Disorders

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 1882

Special Issue Editors


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Guest Editor
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Interests: neurodegeneration; epigenetics; regenerative medicine; mental disorders
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Interests: epigenetics; neurogenesis; neurodevelopment; regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will highlight advances in the research of nervous system disorders, including stroke, trauma, headache, anxiety, depression, epilepsy, autism, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and tumor.

We will welcome critical reviews and high-quality original research articles dedicated to the advances in our understanding of cellular and molecular mechanisms of neurological diseases, and to diagnostic and therapeutic advances in nervous system disorders. The related topics include, but are not limited to, the following:

  • Cellular and molecular mechanisms of altered neurogenesis in brain disease;
  • Microglia in neuroinflammation and neurodegeneration;
  • Advances in brain organoid technologies and their applications;
  • Crosstalk between cancer cells and the nervous system;
  • Crosstalk between gut microbes and the nervous system;
  • Transcriptomic and epigenomic analysis of nervous system disorders;
  • Modeling nervous system disorders using human embryonic stem cells or induced pluripotent stem cells;
  • Deep brain stimulation for neurological and psychiatric disorders;
  • Diagnosing and screening nervous system disorders using artificial intelligence techniques;
  • Gene therapy for nervous system disorders.

We look forward to reading your contributions.

Prof. Dr. Zhao-Qian Teng
Prof. Dr. Changmei Liu
Guest Editors

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Keywords

  • neurological disease
  • psychiatric disorder
  • neurodegeneration
  • brain tumor
  • neuroinflammation
  • neurogenesis
  • gut microbes
  • gene therapy
  • deep brain stimulation
  • modeling neurological disorders
  • diagnosis and screening

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Published Papers (1 paper)

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Review

19 pages, 1198 KiB  
Review
PIWI-Interacting RNAs: A Pivotal Regulator in Neurological Development and Disease
by Xian Pan, Wang Dai, Zhenzhen Wang, Siqi Li, Tao Sun and Nan Miao
Genes 2024, 15(6), 653; https://doi.org/10.3390/genes15060653 - 21 May 2024
Viewed by 1574
Abstract
PIWI-interacting RNAs (piRNAs), a class of small non-coding RNAs (sncRNAs) with 24–32 nucleotides (nt), were initially identified in the reproductive system. Unlike microRNAs (miRNAs) or small interfering RNAs (siRNAs), piRNAs normally guide P-element-induced wimpy testis protein (PIWI) families to slice extensively complementary transposon [...] Read more.
PIWI-interacting RNAs (piRNAs), a class of small non-coding RNAs (sncRNAs) with 24–32 nucleotides (nt), were initially identified in the reproductive system. Unlike microRNAs (miRNAs) or small interfering RNAs (siRNAs), piRNAs normally guide P-element-induced wimpy testis protein (PIWI) families to slice extensively complementary transposon transcripts without the seed pairing. Numerous studies have shown that piRNAs are abundantly expressed in the brain, and many of them are aberrantly regulated in central neural system (CNS) disorders. However, the role of piRNAs in the related developmental and pathological processes is unclear. The elucidation of piRNAs/PIWI would greatly improve the understanding of CNS development and ultimately lead to novel strategies to treat neural diseases. In this review, we summarized the relevant structure, properties, and databases of piRNAs and their functional roles in neural development and degenerative disorders. We hope that future studies of these piRNAs will facilitate the development of RNA-based therapeutics for CNS disorders. Full article
(This article belongs to the Special Issue Advances in Nervous System Disorders)
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