DNA Damage Response Mechanisms in Model Systems

Dear Colleagues,

Cells are constantly assaulted by endogenous and exogenous sources of DNA damage that threaten genome integrity. To deal with this, organisms have evolved a myriad of responses, including transcriptional programs, cell cycle regulation, lesion bypass, and direct repair. While much of the research describing these responses has utilized mammalian cell culture systems, studies performed in model organisms have also provided critical insight into the organismal regulation of damage responses. This Special Issue will highlight discoveries made in the areas of DNA repair and damage responses, with an emphasis on findings from model systems. High-quality investigations and reviews that discuss recent advances and future challenges in the fields of DNA repair and damage response systems are welcomed.

Dr. Jan LaRocque
Dr. Mitch McVey
Guest Editors

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