Genetic Architecture in Complex Traits

Dear Colleagues,

We would like to invite you to participate in this Special Issue, “Genetic Architecture in Complex Traits”.

The emergence of new genetic technologies is a key aspect of progress in the development of molecular medicine. Thanks to these technologies, it is possible to identify the causes of rare monogenic diseases, improve prevention, and improve the effectiveness of the treatment of common complex and infectious diseases.

Today, with an idea of inheritance type, the pathogenetic mechanism of disease development, and the population frequency of SNVs/SNPs, it is possible to annotate and clinically interpret pathogenic variants. However, the natures of these diseases remain unclear: polygenic, oligogenic or multifactorial? It is assumed that this is determined by the contribution of different gene variants, as well as their expressiveness and penetrance. An important feature of the results of modern NGS research methods is that we can detect several hereditary diseases in one person at once. Such findings create difficulties for clinical interpretation, but are extremely important when consulting patients.

Unfortunately, neither new antibiotics nor new vaccines can fundamentally become a solution to the problem of fighting infectious diseases. Therefore, it is necessary to study not only the virus itself and its genome, but also the genome of the host (humans). The COVID-19 pandemic has stimulated large-scale genome-wide research of this kind.

The aim of this Special Issue is to provide an updated view of the current research on the underlying genetic mechanisms of monogenic and common complex and infectious diseases.

Dr. Oleg S. Glotov
Guest Editor

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