RAS Signaling in Health and Disease
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 57846
Special Issue Editor
Special Issue Information
Dear Colleagues,
RAS proteins are key players of signaling cascades that regulate proliferation, differentiation, and apoptosis. Mutations in these proteins or in their effectors, activators, and regulators are associated with the appearance of pathological conditions, particularly the development of various forms of human cancer.
Many aspects of RAS biology have been elucidated since their discovery more than 40 years, but their function and dysfunction in human cancer are not yet fully understood. Efforts to develop therapies directly targeting mutant RAS have been stymied for many years by several factors, including their complex biology and unique structural and biochemical properties. Encouragingly, novel approaches to targeting RAS are showing promising results in cancer patients and are currently one of the hottest topics in cancer therapy. In this Special Issue of Genes on “RAS signaling in Health and Disease”, we will summarize current knowledge on RAS biology both in physiological and pathological conditions, provide an overview of recent developments in specialized research topics, and offer critical perspectives on upcoming challenges.
Dr. Esther Castellano-Sánchez
Guest Editor
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Keywords
- RAS biology
- RAS activators and effectors
- RAS signaling
- RAS and cancer
- Targeting RAS
- RAS models
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