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Advances in miRNA Research
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Advances in miRNA Research

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "RNA".

Deadline for manuscript submissions: closed (20 August 2023) | Viewed by 2083

Special Issue Editor

Dr. Dragoş Creţoiu

E-Mail Website
Guest Editor
Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Interests: circulating miRNA; biomarker; cellular and molecular medicine

Special Issue Information

Dear Colleagues,

In recent years, substantial progress has been made in studying the role of microRNAs (miRNAs) in the pathogenesis of diseases. Numerous studies have shown that these short RNA sequences play a crucial role in the neoplastic process, including cell-death regulation, proliferation, signalling, and the formation of metastasis. Increasing evidence has revealed the deregulation of miRNA levels in cancer and negative regulation of gene and protein expression by acting as oncogenes or tumor suppressors.

This Special Issue invites original papers and reviews covering a wide range of topics related to miRNAs, such as miRNA-activated functional networks, miRNA expression regulation, miRNA therapeutics, miRNA function as biomarkers, and the role of miRNA in cancer drug resistance in various kinds of cancers.

Dr. Dragoş Creţoiu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • miRNA
  • biomarker identification
  • tumor-suppressor
  • diagnosis
  • prognosis

Published Papers (1 paper)

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Research

13 pages, 41660 KiB  
Article
Comparative Analysis of miRNA Expression Profiles under Salt Stress in Wheat
by Hualiang Qiao, Bo Jiao, Jiao Wang, Yang Yang, Fan Yang, Zhao Geng, Guiyuan Zhao, Yongwei Liu, Fushuang Dong, Yongqiang Wang and Shuo Zhou
Genes 2023, 14(8), 1586; https://doi.org/10.3390/genes14081586 - 4 Aug 2023
Viewed by 1803
Abstract
Salt stress is one of the important environmental factors that inhibit the normal growth and development of plants. Plants have evolved various mechanisms, including signal transduction regulation, physiological regulation, and gene transcription regulation, to adapt to environmental stress. MicroRNAs (miRNAs) play a role [...] Read more.
Salt stress is one of the important environmental factors that inhibit the normal growth and development of plants. Plants have evolved various mechanisms, including signal transduction regulation, physiological regulation, and gene transcription regulation, to adapt to environmental stress. MicroRNAs (miRNAs) play a role in regulating mRNA expression. Nevertheless, miRNAs related to salt stress are rarely reported in bread wheat (Triticum aestivum L.). In this study, using high−throughput sequencing, we analyzed the miRNA expression profile of wheat under salt stress. We identified 360 conserved and 859 novel miRNAs, of which 49 showed considerable changes in transcription levels after salt treatment. Among them, 25 were dramatically upregulated and 24 were downregulated. Using real−time quantitative PCR, we detected significant changes in the relative expression of miRNAs, and the results showed the same trend as the sequencing data. In the salt−treated group, miR109 had a higher expression level, while miR60 and miR202 had lower expression levels. Furthermore, 21 miRNAs with significant changes were selected from the differentially expressed miRNAs, and 1023 candidate target genes were obtained through the prediction of the website psRNATarget. Gene ontology (GO) analysis of the candidate target genes showed that the expressed miRNA may be involved in the response to biological processes, molecular functions, and cellular components. In addition, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis confirmed their important functions in RNA degradation, metabolic pathways, synthesis pathways, peroxisome, environmental adaptation, global and overview maps, and stress adaptation and the MAPK signal pathway. These findings provide a basis for further exploring the function of miRNA in wheat salt tolerance. Full article
(This article belongs to the Special Issue Advances in miRNA Research)
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