Pharmaceutical Research in Stem Cells

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Pharmacogenetics".

Deadline for manuscript submissions: closed (25 June 2023) | Viewed by 2760

Special Issue Editor


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Guest Editor
School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
Interests: stem cells; pharmaceutical research; clinical trials; new drug application

Special Issue Information

Dear Colleagues,

Stem-cell-based therapy has become a hot spot in the biomedical field. In past decades, scientists focused on the development of stem cell products for investigational new drug (IND) studies. Many types of stem cell drugs have entered the stage of clinical trials, including functional cells derived from adult stem cells and pluripotent stem cells . Basic studies and clinical trials have demonstrated the evident efficacy of stem-cell therapy in several diseases. Still, a great deal of work remains for the future, from first- to second-generation stem-cell therapies and advancing to next-generation therapies through engineering approaches to improve their function and efficacy or broaden the scope of their clinical application to new indications. Simultaneously, pharmaceutical research in stem cell transplantation should be taken into consideration. Understanding the safety and efficacy, heterogeneity, in vivo fate and distribution of stem cells are the prerequisites for the clinical translation of this technology. This Special Issue of Genes on “Pharmaceutical Research in Stem Cells” will collect related research on the pharmaceutical research of stem cell products in various forms, including case studies, reports, reviews, and original research articles. We aim to provide an overview of recent progress in stem-cell-based medicinal products to provide a meaningful reference for the development of stem cell drugs.

Dr. Wenwen Jia

Guest Editor

Dr. Wenwen Jia
Guest Editor

Manuscript Submission Information

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Keywords

  • Stem-cell-based therapy
  • Stem cell drugs
  • Pharmaceutical research
  • Clinical trials

Published Papers (1 paper)

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Review

16 pages, 952 KiB  
Review
Mesenchymal-Stem-Cell-Based Strategies for Retinal Diseases
by Xiteng Chen, Yuanfeng Jiang, Yanan Duan, Xiaomin Zhang and Xiaorong Li
Genes 2022, 13(10), 1901; https://doi.org/10.3390/genes13101901 - 19 Oct 2022
Cited by 7 | Viewed by 2485
Abstract
Retinal diseases are major causes of irreversible vision loss and blindness. Despite extensive research into their pathophysiology and etiology, pharmacotherapy effectiveness and surgical outcomes remain poor. Based largely on numerous preclinical studies, administration of mesenchymal stem cells (MSCs) as a therapeutic strategy for [...] Read more.
Retinal diseases are major causes of irreversible vision loss and blindness. Despite extensive research into their pathophysiology and etiology, pharmacotherapy effectiveness and surgical outcomes remain poor. Based largely on numerous preclinical studies, administration of mesenchymal stem cells (MSCs) as a therapeutic strategy for retinal diseases holds great promise, and various approaches have been applied to the therapies. However, hindered by the retinal barriers, the initial vision for the stem cell replacement strategy fails to achieve the anticipated effect and has now been questioned. Accumulating evidence now suggests that the paracrine effect may play a dominant role in MSC-based treatment, and MSC-derived extracellular vesicles emerge as a novel compelling alternative for cell-free therapy. This review summarizes the therapeutic potential and current strategies of this fascinating class of cells in retinal degeneration and other retinal dysfunctions. Full article
(This article belongs to the Special Issue Pharmaceutical Research in Stem Cells)
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