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Understanding the Cure of Cancer via Biostatistics Method

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Communication and Informatics".

Deadline for manuscript submissions: closed (30 March 2023) | Viewed by 2240

Special Issue Editor


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Guest Editor
Department of Health Informatics & Biostatistics, Graduate School of Public Health, Yonsei University, Seoul 03722, Korea
Interests: bioinformatics; machine learning; cancer; causal analysis; multiomic data analysis; model-based data integration

Special Issue Information

Dear Colleagues,

The treatment of cancer is evolving through collaborations of multi-disciplinary expertise, which aids in the translation of research into clinical benefits. Biostatistical methods are essential to the establishment of elaborate designs, analyses and interpretations for drug development and repositioning and the systematic prediction of responses. In recent years, the drug profiles of preclinical model systems of cancer such as organoids and patient-derived xenografts have been actively used to explain drug-response heterogeneity and discover novel cancer subtypes and biomarkers. With the availability of multiomic data along with the drug response profiles in these preclinical models, precision oncology that implements genomic-based diagnosis and treatment guidance is rapidly transforming the cures for cancer. The key elements of broad and equitable access to novel cancer therapies will depend on country-specific health care systems as well as particular patient subgroups. However, global challenges exist in the translation of the recent advancements in cancer treatment and the improvement of cancer outcomes at the population level. The main scope of this Special Issue is to highlight real-world evidence that describes the analysis of data via biostatistics methods.

Prof. Dr. Min Jin Ha
Guest Editor

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Keywords

  • biostatistics
  • cancer research
  • real-world data analysis
  • drug-response
  • heterogeneity
  • biomarker
  • subtype
  • prediction
  • data integration
  • precision medicine
  • cancer outcome

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Published Papers (1 paper)

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Research

17 pages, 3792 KiB  
Article
Assessment of Diagnosis, Prognosis and Immune Infiltration Response to the Expression of the Ferroptosis-Related Molecule HAMP in Clear Cell Renal Cell Carcinoma
by Jing Leng, Zixuan Xing, Xiang Li, Xinyue Bao, Junzheya Zhu, Yunhan Zhao, Shaobo Wu and Jiao Yang
Int. J. Environ. Res. Public Health 2023, 20(2), 913; https://doi.org/10.3390/ijerph20020913 - 4 Jan 2023
Cited by 3 | Viewed by 1945
Abstract
Background. Hepcidin antimicrobial peptide (HAMP) is a key factor in maintaining iron metabolism, which may induce ferroptosis when upregulated. However, its prognostic value and relation to immune infiltrating cells remains unclear. Methods. This study analyzed the expression levels of HAMP in the Oncomine, [...] Read more.
Background. Hepcidin antimicrobial peptide (HAMP) is a key factor in maintaining iron metabolism, which may induce ferroptosis when upregulated. However, its prognostic value and relation to immune infiltrating cells remains unclear. Methods. This study analyzed the expression levels of HAMP in the Oncomine, Timer and Ualcan databases, and examined its prognostic potential in KIRC with R programming. The Timer and GEPIA databases were used to estimate the correlations between HAMP and immune infiltration and the markers of immune cells. The intersection genes and the co-expression PPI network were constructed via STRING, R programming and GeneMANIA, and the hub genes were selected with Cytoscape. In addition, we analyzed the gene set enrichment and GO/KEGG pathways by GSEA. Results. Our study revealed higher HAMP expression levels in tumor tissues including KIRC, which were related to poor prognosis in terms of OS, DSS and PFI. The expression of HAMP was positively related to the immune infiltration level of macrophages, Tregs, etc., corresponding with the immune biomarkers. Based on the intersection genes, we constructed the PPI network and used the 10 top hub genes. Further, we performed a pathway enrichment analysis of the gene sets, including Huntington’s disease, the JAK-STAT signaling pathway, ammonium ion metabolic process, and so on. Conclusion. In summary, our study gave an insight into the potential prognosis of HAMP, which may act as a diagnostic biomarker and therapeutic target related to immune infiltration in KIRC. Full article
(This article belongs to the Special Issue Understanding the Cure of Cancer via Biostatistics Method)
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