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2nd Edition: Neuroprotection and Treatment in Intensive Care and Perioperative...
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2nd Edition: Neuroprotection and Treatment in Intensive Care and Perioperative Medicine

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Care Sciences & Services".

Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 1912

Special Issue Editor

Dr. Mirosław Czuczwar

E-Mail Website
Guest Editor
2nd Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, 20-081 Lublin, Poland
Interests: perioperative medicine; intensive care medicine; pharmacology; fluid therapy; nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first Special Issue on Neuroprotection and Treatment in Intensive Care and Perioperative Medicine was a great success. We received a handful of exciting papers focusing on this crucial topic, and we are now ready to continue our project. In this second Special Issue in the International Journal of Environmental Research and Public Health, we would like to focus on: 

  • Postoperative delirium, with particular attention to interventions aiming at reducing its incidence.
  • Neuroprotective compounds and their role in the ICU and the perioperative setting.
  • Cognitive impairment and dementia following ischemic stroke and cardiac arrest.
  • Role of neuroprotection in patients suffering from traumatic brain injury.
  • New findings on the mechanisms of neuroprotection in the preclinical setting.

Dr. Mirosław Czuczwar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • perioperative medicine
  • neuroprotection
  • ICU
  • traumatic brain injury
  • anesthesia
  • stroke
  • sudden cardiac arrest

Related Special Issue

Published Papers (1 paper)

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Research

14 pages, 1958 KiB  
Article
Dexmedetomidine Increases MMP-12 and MBP Concentrations after Coronary Artery Bypass Graft Surgery with Extracorporeal Circulation Anaesthesia without Impacting Cognitive Function: A Randomised Control Trial
by Michał Kowalczyk, Anna Panasiuk-Kowalczyk, Adam Stadnik, Małgorzata Guz, Marek Cybulski, Witold Jeleniewicz, Andrzej Stepulak and Magdalena Kwiatosz-Muc
Int. J. Environ. Res. Public Health 2022, 19(24), 16512; https://doi.org/10.3390/ijerph192416512 - 8 Dec 2022
Cited by 2 | Viewed by 1519
Abstract
Postoperative neurological deficits remain a concern for patients undergoing cardiac surgeries. Even minor injuries can lead to neurocognitive decline (i.e., postoperative cognitive dysfunction). Dexmedetomidine may be beneficial given its reported neuroprotective effect. We aimed to investigate the effects of dexmedetomidine on brain injury [...] Read more.
Postoperative neurological deficits remain a concern for patients undergoing cardiac surgeries. Even minor injuries can lead to neurocognitive decline (i.e., postoperative cognitive dysfunction). Dexmedetomidine may be beneficial given its reported neuroprotective effect. We aimed to investigate the effects of dexmedetomidine on brain injury during cardiac surgery anaesthesia. This prospective observational study analysed data for 46 patients who underwent coronary artery bypass graft surgery with extracorporeal circulation between August 2018 and March 2019. The patients were divided into two groups: control (CON) with typical anaesthesia and dexmedetomidine (DEX) with dexmedetomidine infusion. Concentrations of the biomarkers matrix metalloproteinase-12 (MMP-12) and myelin basic protein (MBP) were measured preoperatively and at 24 and 72 h postoperatively. Cognitive evaluations were performed preoperatively, at discharge, and 3 months after discharge using Addenbrooke’s Cognitive Examination version III (ACE-III). The primary endpoint was the ACE-III score at discharge. Increased MMP-12 and MBP concentrations were observed in the DEX group 24 and 72 h postoperatively. No significant differences in ACE-III scores were observed between the groups at discharge; however, the values were increased when compared with initial values after 3 months (p = 0.000). The current results indicate that the administration of dexmedetomidine as an adjuvant to anaesthesia can increase MMP-12 and MBP levels without effects on neurocognitive outcomes at discharge and 3 months postoperatively. Full article
(This article belongs to the Special Issue 2nd Edition: Neuroprotection and Treatment in Intensive Care and Perioperative Medicine)
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