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Advances in Gastrointestinal Health
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Advances in Gastrointestinal Health

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Global Health".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 4589

Special Issue Editors

Dr. Radosław Kempiński

E-Mail Website
Guest Editor
Department of Gastroenterology and Hepatology, Wroclaw Medical University, 50–556 Wroclaw, Poland
Interests: inflammatory bowel disease; biomarkers; colon; liver; Helicobacter; digestive cancer; pancreas
Prof. Dr. Katarzyna Neubauer

E-Mail Website
Guest Editor
Department of Gastroenterology and Hepatology, Wroclaw Medical University, 50-556 Wroclaw, Poland
Interests: inflammatory bowel disease; biomarkers; colon; liver; Helicobacter; digestive cancer; pancreas

Special Issue Information

Dear Colleagues,

Gastrointestinal diseases are currently a leading issue in modern health systems. From an epidemiological point of view, even if there is a geographical variation in their prevalence,  they are one of most common disorders worldwide. For instance, gastroesophageal reflux disease affects approximately 20% of population, irritable bowel syndrome 1 in 10 individuals,  and non-alcoholic fatty liver disease can be recognized in 24% of the global population. Likewise, there is a rising prevalence of digestive tract cancers, corresponding with recent changes in lifestyle and the growing global incidence of obesity. We are witnessing the alterations of the age profile of patients, for example, inflammatory bowel diseases are more frequently diagnosed in elderly populations, and colorectal cancer in younger individuals. At the same time, there is a growing body of evidence on the relation between microbiome and health and diseases. Furthermore, the complex relations between microbiome and environment are implicated in the pathogenesis of multiple diseases, thus creating the opportunity for the development of novel diagnostic and therapeutic strategies.

The aim of this Special Issue of the International Journal of Environmental Research and Public Health is to demonstrate recent progress in the knowledge on gastrointestinal health with special attention focused on the environment.

Dr. Radosław Kempiński
Prof. Dr. Katarzyna Neubauer
Guest Editors

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Keywords

  • recent advances in diagnosis
  • prevention
  • therapy
  • long-term complications
  • quality of life in gastrointestinal diseases
  • risk factors
  • epidemiology
  • diet
  • gastrointestinal diseases in the elderly

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Published Papers (2 papers)

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16 pages, 1447 KiB  
Article
Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings
by Marija Mihajlović, Ana Ninić, Marija Ostojić, Miron Sopić, Aleksandra Stefanović, Jelena Vekić, Tamara Antonić, Dejan Zeljković, Bratislav Trifunović, Vesna Spasojević-Kalimanovska, Nataša Bogavac Stanojević, Ivan Jančić and Aleksandra Zeljković
Int. J. Environ. Res. Public Health 2022, 19(22), 14995; https://doi.org/10.3390/ijerph192214995 - 14 Nov 2022
Cited by 2 | Viewed by 1586
Abstract
Adiponectin (ADIPOQ) as both a regulator of metabolic homeostasis and a protein involved in immune response might be of particular interest to contemporary laboratory medicine, especially in terms of minimally invasive diagnostics. The diverse roles of ADIPOQ with regard to the immune and [...] Read more.
Adiponectin (ADIPOQ) as both a regulator of metabolic homeostasis and a protein involved in immune response might be of particular interest to contemporary laboratory medicine, especially in terms of minimally invasive diagnostics. The diverse roles of ADIPOQ with regard to the immune and metabolic aspects of colorectal carcinogenesis have been proposed. However, the expression of its receptors ADIPOR1 and ADIPOR2 is scarcely explored in peripheral blood mononuclear cells (PBMCs). Moreover, ADIPORs’ relationships with the immune response mediator TNF-α have not been previously investigated in the PBMCs of CRC patients. This study used both in silico and observational case–control analyses with the aim of exploring the association of ADIPOR gene expression and ADIPOQ single nucleotide polymorphisms (SNPs) with the inflammatory marker TNF-α and lipid status parameters in patients with CRC. Publicly available transcriptomic datasets (GSE47756, GSE44076) obtained from analyses of monocytes and CRC tissue samples were employed for the in silico evaluation of ADIPORs’ specific genetic traits. GSE47756 and GSE44076 datasets were processed with GSEA software to provide a genetic fingertip of different signaling pathways associated with ADIPORs’ mRNA levels. The case–control aspect of the study included the PBMC samples of 73 patients diagnosed with CRC and 80 healthy volunteers. The PCR method was carried out for the PBMC gene expression analysis (ADIPOR1, ADIPOR2, TNF-α mRNA levels) and for the subjects’ genotyping (ADIPOQ rs266729, ADIPOR1 rs7539542). GSEA showed significant associations of ADIPOR mRNA expression with gene sets related to metabolic and immune homeostasis in both datasets. The case–control study revealed the association of ADIPOR1 rs7539542 with reduced lipid status parameters in CRC. In addition, PBMC ADIPOR1 mRNA levels decreased in CRC (p < 0.001), whereas ADIPOR2 mRNA did not differ between the groups (p = 0.442). A reduction in PBMC TNF-α mRNA levels was noted in CRC (p < 0.05). Our results indicate that ADIPOR1 and ADIPOR2 play a significant role in the alteration of both metabolic and immune homeostasis during the progression of CRC. For the first time, ADIPOR1 is shown to be a specific receptor for mediating ADIPOQ’s effects in the PBMCs of CRC patients. Full article
(This article belongs to the Special Issue Advances in Gastrointestinal Health)
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15 pages, 772 KiB  
Systematic Review
Pancreatic Cancer in Celiac Disease Patients—A Systematic Review and Meta-Analysis
by Iga Gromny and Katarzyna Neubauer
Int. J. Environ. Res. Public Health 2023, 20(2), 1565; https://doi.org/10.3390/ijerph20021565 - 14 Jan 2023
Cited by 3 | Viewed by 2538
Abstract
Background: Celiac disease (CD) is an autoimmune enteropathy affecting approximately 1% of the population and is associated with an increased risk of enteropathy-associated T-cell lymphoma and small bowel adenocarcinoma, whereas the association between CD and other malignancies is unclear. Since pancreatic cancer (PC) [...] Read more.
Background: Celiac disease (CD) is an autoimmune enteropathy affecting approximately 1% of the population and is associated with an increased risk of enteropathy-associated T-cell lymphoma and small bowel adenocarcinoma, whereas the association between CD and other malignancies is unclear. Since pancreatic cancer (PC) remains one of the most lethal neoplasms and its incidence is increasing despite numerous ongoing research on diagnostic biomarkers and novel therapies, we aimed to investigate whether CD has an impact on the risk of PC. Material and Methods: We performed a systematic review of the literature published from January 2000 to March 2022 in two databases: Web of Science and Scopus and a meta-analysis of eligible studies. Results: Our search identified eight publications included in the systematic review. A total of five studies involving 47,941 patients, including 6399 CD patients with malignancies and 1231 PC cases were included in the meta-analysis and 221 cases of PC in CD patients with other cancers were recognized. The pooled OR for PC was 1.46 (95% CI 1.26–1.7) with significant heterogeneity (89.1%; p < 0.05), suggesting that CD patients with malignancies were at higher risk for PC. Conclusions: The association between CD and PC is uncertain. However, the results of the current meta-analysis may indicate an increased risk of PC in the group of patients with CD and other cancers. Further multicenter studies are warranted. Full article
(This article belongs to the Special Issue Advances in Gastrointestinal Health)
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