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IJERPH
Special Issues
Environment and Human Toxicological Risk: Experiences and Challenges
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Environment and Human Toxicological Risk: Experiences and Challenges

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Toxicology and Public Health".

Deadline for manuscript submissions: closed (26 June 2023) | Viewed by 1889

Special Issue Editors

Dr. Jianyun Zhang

E-Mail Website
Guest Editor
Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University, Hangzhou 311121, China
Interests: environmental health; human biomonitoring; environmental toxicology; persistent organic pollutants; flame retardants
Dr. Shanshan Yin

E-Mail Website1 Website2
Guest Editor
1. Interdisciplinary Research Academy, Zhejiang Shuren University, Hangzhou 310015, China
2. Toxicological Centre, University of Antwerp, 2610 Wilrijk, Belgium
Interests: exposure sciences; aggregate exposure pathways; emerging POPs; environmental chemistry; environmental toxicology; analytical chemistry; polychlorinated alkanes; human biomonitoring; exposome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The identification and characterization of environment and human toxicological risk remain long-term challenges in environmental research and public health. Thousands of chemicals are currently produced and used, together with a few hundred new chemicals being designed and developed every year. These chemicals are ubiquitously detected in environmental media and biota matrices. At the same time, legacy pollutants, such as chlorinated pesticides and their metabolites, are still a concern due to their high detection rates in the general population. Other environmental stressors, such as magnetic fields and noise, also induce short- and long-term implications for human health. Only a few of these environmental stressors and even fewer combination mixtures have been thoroughly studied in regard to their health risks, which represent continuous challenges for toxicological research.

This Special Issue of the International Journal of Environmental Research and Public Health (IJERPH) focuses on the resulting knowledge gained about environmental stressors and their risks to human health. New research papers, reviews, case reports, and conference papers that fulfill knowledge gaps as well as present conclusions or perspectives on environment and human toxicological risk are welcome to this Special Issue. Other manuscript types, including methodological papers, brief reports, and commentaries, that provide new advanced approaches or insights to monitor, model, and assess environmental health are also welcome. 

Dr. Jianyun Zhang
Dr. Shanshan Yin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemical pollutants
  • environmental health
  • human biomonitoring
  • risk assessment
  • toxicity
  • exposome
  • exposure modeling
  • emerging and legacy persistent organic pollutants

Published Papers (1 paper)

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Research

19 pages, 3289 KiB  
Communication
Particulate Matter Elevates Ocular Inflammation and Endoplasmic Reticulum Stress in Human Retinal Pigmented Epithelium Cells
by Sunyoung Jeong, Eui-Cheol Shin, Jong-Hwa Lee and Jung-Heun Ha
Int. J. Environ. Res. Public Health 2023, 20(6), 4766; https://doi.org/10.3390/ijerph20064766 - 8 Mar 2023
Cited by 1 | Viewed by 1531
Abstract
Because of their exposure to air, eyes can come into contact with air pollutants such as particulate matter (PM), which may cause severe ocular pathologies. Prolonged ocular PM exposure may increase inflammation and endoplasmic reticulum stress in the retina. Herein, we investigated whether [...] Read more.
Because of their exposure to air, eyes can come into contact with air pollutants such as particulate matter (PM), which may cause severe ocular pathologies. Prolonged ocular PM exposure may increase inflammation and endoplasmic reticulum stress in the retina. Herein, we investigated whether PM exposure induces ocular inflammation and endoplasmic reticulum (ER) stress-related cellular responses in human retinal epithelium-19 (ARPE-19) cells. To understand how PM promotes ocular inflammation, we monitored the activation of the mitogen-activated protein kinase (MAPK)/nuclear factor kappa beta (NFκB) axis and the expression of key inflammatory mRNAs. We also measured the upregulation of signature components for the ER-related unfolded protein response (UPR) pathways, as well as intracellular calcium ([Ca2+]i) levels, as readouts for ER stress induction following PM exposure. Ocular PM exposure significantly elevated the expression of multiple cytokine mRNAs and increased phosphorylation levels of NFκB-MAPK axis in a PM dose-dependent manner. Moreover, incubation with PM significantly increased [Ca2+]i levels and the expression of UPR-related proteins, which indicated ER stress resulting from cell hypoxia, and upregulation of hypoxic adaptation mechanisms such as the ER-associated UPR pathways. Our study demonstrated that ocular PM exposure increased inflammation in ARPE-19 cells, by activating the MAPK/NFκB axis and cytokine mRNA expression, while also inducing ER stress and stress adaptation responses. These findings may provide helpful insight into clinical and non-clinical research examining the role of PM exposure in ocular pathophysiology and delineating its underlying molecular mechanisms. Full article
(This article belongs to the Special Issue Environment and Human Toxicological Risk: Experiences and Challenges)
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