Novel Insights into the Identification of Anticancer Agents Targeting Malignant Tumors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 May 2026 | Viewed by 3
Special Issue Editor
Interests: anti-cancer drug resistance; cancer recurrence; cancer metastasis; cancer stem cells; target valida-tion; target identification
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer drug discovery has significantly advanced since its earliest steps. However, rare occurrences of anticancer-drug-resistant cancer show a poor prognosis via recurrence or metastasis, and these can result in patient death. Various studies have shown that recurrent or metastatic cancer is refractory to most medical treatments. These refractory cancers are usually slow; however, following anaplasia of the injury, they are altered into poorly differentiated and undifferentiated cancer, characterized by a sharp expansion involving a poor prognosis. The stemness and aggressiveness of refractory cancer have not yet been fully understood. Studies exploring outcomes of the advances in anticancer drugs have found that pre-operative chemotherapy can extend survival rates after surgery. Nonetheless, no selective therapeutic options have been accepted as the basal adjuvant or neoadjuvant background for drug-resistant cancer, and a substantial number of anticancer-drug-resistant cancer patients have died; therefore, unmet medical needs have consistently increased. Refractory cancer due to drug resistance, which mediates metastasis and recurrence, represents a significant proportion of unmet medical needs. For these reasons, anticancer drug resistance in refractory cancer represents a primary challenge in cancer therapy. This Special Issue is aimed at highlighting contributions that could be potentially exploited as breakthrough molecular mechanism to drug-resistant cancer.
Dr. Ki-Cheong Park
Guest Editor
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Keywords
- cancer metastasis
- drug-resistant
- cancer recurrence
- targeted therapy
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