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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biosynthesis and Application of Natural Compound

edited by

Konstantin Volcho

and

Olga Luzina

submission deadline 20 May 2025 | 16 articles | Viewed by 34613

Keywords: natural compounds; biosynthesis; biotransformation; metabolism; derivatives of natural compounds; medicines/medication; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Potential Roles of Natural Active Products in Neurological Disorders

edited by Anna D. Serefko

submission deadline 20 May 2025 | 3 articles | Viewed by 27077

Keywords: natural active products; phytochemicals; bioactive compounds; Neurological Disorders; depressive disorders; Parkinson's disease; depressive/epileptic episodes; antidepressants and antiepileptics; Alzheimer's disease; brain stroke; molecular mechanism; drug delivery; therapeutic potentials; structure-activity relationships; advanced therapies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Natural Compounds in Cancer and Inflammation

edited by

Elia Ranzato

submission deadline 20 May 2025 | 9 articles | Viewed by 23684

Keywords: natural compounds; oxidative stress; anti-cancer; anti-inflammatory; natural product synthesis and biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mitochondrial Genome of Aquatic Animals: Analysis of Structure, Evolution and Diversity

edited by

Yuri Kartavtsev

and

Ui Wook Hwang

submission deadline 20 May 2025 | 12 articles | Viewed by 23217

Keywords: aquatic animals; genomics; mitogenomes; structure; phylogenetic informativeness; evolution; comparative genomics; diversity; biomarker; function; mitonuclear relations

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pathogenesis and Treatments of Head and Neck Cancer

edited by

Marko Tarle

submission deadline 20 May 2025 | 12 articles | Viewed by 23101

Keywords: HNSCC; premalignant changes; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis; molecular pathogenesis; tumor biology; tumor immunology

(This special issue belongs to the Section Molecular Oncology)

New Pharmacological Insights on Natural Macromolecules and Natural Small Molecules

edited by

Dong-Sung Lee

submission deadline 20 May 2025 | 8 articles | Viewed by 22795

Keywords: bioactive natural molecules; natural macromolecules; natural small molecules; drug delivery; inflammatoty diseases; neurodegenerative diseases; skin diseases; cancer; metabolic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Molecular Mechanisms of Human Papillomavirus Family (HPV) Induced Oncogenesis

edited by

Subhasis B. Biswas

submission deadline 20 May 2025 | 9 articles | Viewed by 22712

Keywords: human papillomavirus (HPV); oncogenesis; mechanism; diagnosis; classification; etiology; pathophysiology; biochemistry; genetics; molecular biology; epidemiology; cervical cancer; oropharyngeal cancer; oncology

(This special issue belongs to the Section Molecular Oncology)

Health Promoting Benefits of Natural Products and Functional Foods

edited by

Andrea Zangara

and

Emad Al-Dujaili

submission deadline 20 May 2025 | 8 articles | Viewed by 22535

Keywords: natural products; functional foods; health promotion; nutrigenomics; evidence-based preventive healthcare; phytochemicals; biomarkers; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanism of Enzyme Catalysis: When Structure Meets Function

edited by Ivana Leščić Ašler

submission deadline 20 May 2025 | 13 articles | Viewed by 20621

Keywords: three-dimensional structure of enzymes; enzyme stability; solubility and flexibility; structure-function relationship in enzymes; mechanism of enzyme catalysis; enzyme kinetics; substrate specificity of enzymes; regulation of enzyme activity; enzyme engineering

(This special issue belongs to the Section Biochemistry)

Blast-Induced Neurotrauma: Molecular Mechanisms Supported by Comparative Experimental and Clinical Findings

edited by

Ibolja Cernak

submission deadline 20 May 2025 | 8 articles | Viewed by 20516

Keywords: blast injuries; blast-induced neurotrauma; experimental research; experimental models; clinical research; molecular mechanisms; biomarkers; imaging; neurological deficits; treatment

(This special issue belongs to the Section Molecular Neurobiology)

Dental Health and Disease: From the Molecular and Pathological Perspectives

edited by

Ancuţa Goriuc

and

Ionut Luchian

submission deadline 20 May 2025 | 15 articles | Viewed by 19971

Keywords: dental health; oral diseases; molecular mechanisms; pathological mechanisms; treatment perspectives; dentistry; oral medicine; oral pathology; physiopathology in dentistry; periodontal disease; oral fluids

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Biology: From Genetic Aspects to Treatment

edited by

Silvia Cantara

submission deadline 20 May 2025 | 13 articles | Viewed by 19537

Keywords: cancer biology; cancer biomarker; cancer progression; cancer metastasis; genetic of cancer

(This special issue belongs to the Section Molecular Oncology)

Bioactive Lipids: From the Perspective of Cellular and Molecular Mechanisms

edited by

Igor Manzhulo

and

Anna A. Tyrtyshnaia

submission deadline 20 May 2025 | 9 articles | Viewed by 19471

Keywords: lipids; polyunsaturated fatty acids; lipid metabolism; lipid mediators; inflammation; neuroprotection

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Research on Immune Response to Viral Infection

edited by Tatiana Betáková

submission deadline 20 May 2025 | 6 articles | Viewed by 18472

Keywords: virus; infection; immunity; signaling pathways; cytokine; antibody; pathology

(This special issue belongs to the Section Molecular Immunology)

Synthesis and Molecular Research of Drugs for Skin Diseases and Cosmetic Ingredients

edited by

Elzbieta Budzisz

and Paulina Mucha

submission deadline 20 May 2025 | 4 articles | Viewed by 18400

Keywords: skin diseases; skin cancers; aging; pathogenesis; topical dermatological therapy; systemic dermatological therapy; cosmetic ingredients; molecular mechanism; drugs design and synthesis; molecular mechanism

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Retinal Diseases: 2nd Edition

edited by Minzhong Yu

submission deadline 20 May 2025 | 7 articles | Viewed by 17176

Keywords: retina; optic nerve; ocular disorder; retinal disease; genetic mutation; aging; drug side effects; novel mutations/biomarkers; signaling pathways; spectral domain optical coherence tomography; stem cell; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Short and Long-Term Profound Acid Inhibition: Indications and Concerns

edited by

Helge L. Waldum

submission deadline 20 May 2025 | 3 articles | Viewed by 16612

Keywords: gastric acid; gastric cancer; gastric neuroendocrine tumours; gastric juice; gastrin; Helicobacter pylori; oesophageal reflux disease; pepsin; peptic ulcer disease; gastric cancer histology and classification; rebound acid hypersecretion

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunity in Neurodegenerative Diseases: Systemic Immune Imbalance, Neuroinflammation, and Beyond

edited by

Ivana Munitic

and

Frenkel Dan

submission deadline 20 May 2025 | 9 articles | Viewed by 16502

Keywords: neurodegeneration; CNS immunosurveillance; neuroinflammation; neuro-immune axis; glia; T cells; phagocytosis; immunomodulation; autoimmunity; immunodeficiency

(This special issue belongs to the Section Molecular Neurobiology)

Melanoma: Molecular Mechanisms and Therapy

edited by

Balázs Margit

submission deadline 20 May 2025 | 9 articles | Viewed by 16355

Keywords: melanoma progression; melanoma metastasis molecular background; targeted therapy; immunotherapy; acquired drug resistance; prognostic and predictive markers; therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0

edited by

Antonio Carrillo-Vico

and

Ivan Cruz-Chamorro

submission deadline 20 May 2025 | 6 articles | Viewed by 16336

Keywords: oxidative stress; inflammation; metabolism; plant bioactive compounds; functional food; nutraceuticals; natural extracts; human health; nutrition; metabolic syndrome; chronic diseases; cardiovascular diseases; cancer

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies

edited by

Masaru Tanaka

submission deadline 20 May 2025 | 6 articles | Viewed by 16188

Keywords: molecular psychiatry; biomarkers; pharmacogenomics; precision medicine; gene-environment Interaction; neuroinflammation; immune modulation; neuroimaging; molecular imaging; psychiatric disorders

(This special issue belongs to the Section Molecular Neurobiology)

Advances in the Prevention and Treatment of Ischemic Diseases

edited by

Egor Yu. Plotnikov

submission deadline 20 May 2025 | 7 articles | Viewed by 15518

Keywords: stroke; acute kidney injury; dietary approaches; liver ischemia; heart attack; stem cells; hypoxia; preconditioning; antioxidants

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in New Combination Therapies for Cancer

edited by Valeria Lucarini and

Camilla Palumbo

submission deadline 20 May 2025 | 6 articles | Viewed by 15101

Keywords: immunotherapy; target therapy; chemotherapy; tumor microenvironment; combination therapies; preclinical models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Anti-cancer Effects of Natural Products

edited by

Moon Nyeo Park

submission deadline 20 May 2025 | 6 articles | Viewed by 15042

Keywords: cancer; natural products; herbal medicine; anticancer therapies; metastasis; recurrence; resistance mechanism; novel biomarker

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Therapeutics against Eukaryotic Pathogens

edited by

Edward D’Antonio

submission deadline 20 May 2025 | 6 articles | Viewed by 14703

Keywords: medicinal chemistry; parasitology; pathogen; drug-target; NTD; cryptosporidia; Giardia; helminths; Leishmania; Naegleria; Plasmodium; Schistosoma; Toxoplasma; Trichomonas; Trypanosoma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomimetic Materials Applied in the Analytical and Biomedical Fields

edited by

Iacob Bogdan-Cezar

and

Ede Bodoki

submission deadline 20 May 2025 | 6 articles | Viewed by 14356

Keywords: biomimetics; molecular recognition; imprinted polymers; smart materials; molecular complexes; polymeric biomaterials; biomedical materials; analytical methods; molecular interactions; artificial receptors

(This special issue belongs to the Section Materials Science)

Molecular Progression of Genome-Related Diseases

edited by

Salvatore Saccone

and

Francesco Calì

submission deadline 20 May 2025 | 9 articles | Viewed by 13934

Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Advances in Liver Fibrosis

edited by

Domenica Mangieri

submission deadline 20 May 2025 | 4 articles | Viewed by 13900

Keywords: liver fibrosis; inflammation; hypoxia; angiogenesis; hepatic stellate cells; drug therapy; natural compounds; phytochemicals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Omics Era: From Principles to Applications in Disease Diagnosis and Treatment

edited by

Kieu The Loan Trinh

submission deadline 20 May 2025 | 6 articles | Viewed by 13810

Keywords: genomics; metagenomics; transcriptomics; proteomics; metabolomics; functional genomics; functional metagenomics; omics-based diagnostics

(This special issue belongs to the Section Molecular Informatics)

Latest Review Papers in Molecular Oncology 2024

edited by

Carmine Stolfi

Massimo Nabissi

and

Peter J. K. Kuppen

submission deadline 20 May 2025 | 6 articles | Viewed by 13610

Keywords: review; molecular oncology; cancer genetics and epigenetics

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Atherosclerosis

edited by Michishige Terasaki

submission deadline 20 May 2025 | 6 articles | Viewed by 13533

Keywords: atherosclerosis; dyslipidemia; genes; macrophages; diabetes; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research in Prediction of Protein Structure and Function, 2nd Edition

edited by

Shuai Cheng Li

submission deadline 20 May 2025 | 5 articles | Viewed by 13525

Keywords: prediction; protein structure; protein function; protein complex; machine learning; deep learning; multiple sequence alignment

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms Subserving Taste and Olfaction Systems

edited by

Lindsey Schier

submission deadline 20 May 2025 | 7 articles | Viewed by 13203

Keywords: taste; olfaction; gustation; odor; chemoreception; taste bud cells; nutrient sensing; ingestive behavior; olfactory cilia; olfactory receptor neurons; olfactory bulb; gustatory cortex; piriform cortex; sensory development; food learning; neural plasticity; obesity; eating disorders; appetite

(This special issue belongs to the Section Molecular Neurobiology)

Viral and Host Targets to Fight RNA Viruses

edited by

Tommaso Felicetti

submission deadline 20 May 2025 | 6 articles | Viewed by 13194

Keywords: RNA viruses; antiviral agents; medicinal chemistry; direct-acting antivirals; host-targeting agents; drug design

(This special issue belongs to the Section Molecular Genetics and Genomics)

Insights on the Role of Stem Cells in Tendon Tissue Engineering: From Basic Science to Translational Medicine

edited by

Maria Camilla Ciardulli

and

Nicola Maffulli

submission deadline 20 May 2025 | 5 articles | Viewed by 13094

Keywords: stem cells; tenogenic differentiation; 3D in vitro tendon models; immunomodulation; biomimetic scaffolds; in vivo tendon models; dynamic cultures

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic Engineering in Microbial Biotechnology

edited by

Fernando Santos-Beneit

submission deadline 20 May 2025 | 7 articles | Viewed by 13039

Keywords: white biotechnology; red biotechnology; green biotechnology; yellow biotechnology; genetic engineering; microorganisms; bacteria; enzymes; genetics; bioproducts

(This special issue belongs to the Section Molecular Microbiology)

Immunotherapy: A New Perspective in Cancer Treatment

edited by Ivana Marinović-Terzić

submission deadline 20 May 2025 | 5 articles | Viewed by 13024

Keywords: immunotherapy; cancer treatment; breakthroughs; oncology; checkpoint inhibitors; CAR-T cell therapy; therapeutic vaccines; clinical trials; accessible healthcare

(This special issue belongs to the Section Molecular Immunology)

Mechanisms of Immune Tolerance and Autoimmune Diseases

edited by

Marcos López Hoyos

and

Jordi Ochando

submission deadline 20 May 2025 | 1 articles | Viewed by 12936

Keywords: immunological tolerance; autoimmune diseases; autoinflammatory diseases; inflammation; immune-mediated diseases

(This special issue belongs to the Section Molecular Immunology)

Structural Dynamics of Macromolecules

edited by

Ki Hyun Nam

submission deadline 20 May 2025 | 7 articles | Viewed by 12698

Keywords: Structural biology; Structural dynamics; Serial crystallography; X-ray crystallography; Cryo-EM time-resolved studies; Molecular dynamics

(This special issue belongs to the Section Molecular Biophysics)

Molecular Aspects of Haemorrhagic and Thrombotic Disorders

edited by

Giovanni Luca Tiscia

submission deadline 20 May 2025 | 6 articles | Viewed by 12612

Keywords: next-generation sequencing; whole-exome sequencing; haemorrhagia; thrombosis; molecular biology; diagnosis; genetics; blood coagulation disorders; inherited

(This special issue belongs to the Section Molecular Biology)

Molecular Pathogenesis and Diagnostics of Lung Diseases

edited by

Amanda Iglesias

submission deadline 20 May 2025 | 6 articles | Viewed by 12542

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunological and Molecular Networks in the Skin and Skin Diseases

edited by

Ankit Srivastava

submission deadline 20 May 2025 | 4 articles | Viewed by 12375

Keywords: skin diseases; skin immunology; skin inflammation; skin aging; skin cancers; cytokine/chemokine networks; molecular signaling pathways; non-coding RNAs; targeted therapies

(This special issue belongs to the Section Molecular Immunology)

News in Skin Diseases: From Basic Mechanisms to Therapies

edited by

Takemichi Fukasawa

submission deadline 20 May 2025 | 4 articles | Viewed by 11909

Keywords: skin diseases; psoriasis; atopic dermatitis; scleroderma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Focus on Antioxidants and Human Diseases

edited by

Marija S. Plješa-Ercegovac

submission deadline 20 May 2025 | 4 articles | Viewed by 11756

Keywords: antioxidants; epidemic; COVID-19; oxidative stress; antioxidant capacity; vitamins; human diseases

(This special issue belongs to the Section Biochemistry)

Latest Research on Mesenchymal Stem Cells

edited by Marcel Costuleanu

submission deadline 20 May 2025 | 7 articles | Viewed by 11570

Keywords: mesenchymal stem cell; MSC; niche; tissue homeostasis; exosomes; microvesicles; cancer; mitochondrial exchange; MSC secretome

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Skeletal Muscle Biology

edited by

Atsushi Asakura

submission deadline 20 May 2025 | 6 articles | Viewed by 11527

Keywords: skeletal muscle; muscular dystrophy; satellite cell; muscle regeneration; myofibrosis; exercise

(This special issue belongs to the Section Molecular Biology)

The Role of Cytokines in Diseases

edited by

Svetlana Khaiboullina

submission deadline 20 May 2025 | 6 articles | Viewed by 11505

Keywords: cytokines; inflammation; immune response; genetics; epigenetics; disease; infection; pathogen-associated molecular patterns; damage-associated molecular patterns; pattern-recognizing receptors; treatment

(This special issue belongs to the Section Biochemistry)

Influenza Viruses: Infection and Genomics

edited by