Molecular Studies of Age-Related Diseases: Immunosenescence and Inflammaging
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 December 2024
Special Issue Editor
Special Issue Information
Dear Colleagues,
Aging results from the cumulative dysfunction of the various organs and systems, with implications on morbidity and mortality. Immunosenescence is the remodeling of the immune system accompanying aging, characterized by the defects in immunocompetent capacity and tumor immunosurveillance, and inflammaging is a condition of low-grade inflammation, contributing to the onset and progression of age-related diseases. In the elderly, nutritional deficits and hormonal dysfunctions impact on the immune system. Complex interactions of metabolic and immunological pathways, as well as genetic and epigenetic regulation of defenses against oxidative damage and responses to stress, drive both senescence and inflammaging.
The aim of this Special Issue is to collect the most recent preclinical and molecular research and the current concepts about the interconnected signals linking aging and immunosenescence as well as other homeostatic system dysfunctions in the elderly and their translational implications.
Prof. Dr. Lia Ginaldi
Guest Editor
Manuscript Submission Information
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Keywords
- aging
- age-related
- immunosenescence
- immune system
- inflammaging
