Innovative Molecular Diagnostic and Therapeutic Strategies for Biofilm-Associated Periprosthetic Joint Infections
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 22
Special Issue Editor
Interests: hip revision; periprosthetic joint infection; targeted radionuclide therapy; antibacterial coating; hip dysplasia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Periprosthetic joint infections (PJI) are severe and challenging complication of joint replacement surgery, mainly due to biofilm formation that is highly resistant to antibiotics and host immune response. This special issue aims to compile cutting-edge research that addresses these challenges through innovative diagnostic techniques and therapeutic strategies. We seek to explore the mechanisms of biofilm formation, resistance, and persistence in PJI and the latest advancements in molecular diagnostic technologies such as antibody/aptamer-based in vivo imaging. These technologies have the potential to significantly improve the early diagnosis rate and accuracy of PJI. For treatment, topics of interest include the use of nanotechnology to enhance antibiotic efficacy, the development of biofilm disruptors, and the application of novel immunotherapies and targeted therapies specifically designed to combat biofilm-related infections. Additionally, we encourage research into the development of novel prosthetic materials and surface modifications aimed at preventing biofilm formation.
Dr. Bart C.H. van der Wal
Guest Editor
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Keywords
- periprosthetic joint infections
- biofilm
- antimicrobial resistance
- diagnosis
- therapy
- nanotechnology
- antibody
- ap-tamer
- prosthetic materials
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