Nose-to-Brain Drug Delivery: Opportunities and Challenges
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 46
Special Issue Editor
Interests: nasal formulation; nasal drug delivery; mucosal absorption; CNS drug delivery; brain drug targeting; neuroinflammation; neuropathic pain; neurodegenerative diseases; sleep cycle; chronopharmacology; circadian rhythm
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recently, the research and development of novel therapeutic agents for CNS diseases has been a key topic. Although potential drug candidates are developed and their therapeutic efficacy can be demonstrated in vitro, the drug delivery to the brain/CNS in vivo remains a challenging issue. Therefore, the nose-to-brain drug delivery system, which can bypass the blood–brain barrier and non-invasively deliver drugs to the brain/CNS directly, has attracted attention, and numerous reports of basic and clinical findings have been accumulated to date. The nose-to-brain drug delivery system is not limited to small molecular weight compounds but can also deliver a variety of medium-to-large molecules such as peptides, proteins, antibodies, nucleic acids, and genes. The nose-to-brain drug delivery system is therefore considered an attractive and potential drug delivery technology that can be used for next-generation drug candidates.
This Special Issue targets new research reports on drug delivery to the brain/CNS using intranasal administration for various pharmaceutical modalities and also accepts the most recent review articles. In vivo studies and clinical trials are preferable, but in vitro research that is directly related to in vivo studies is also included.
Dr. Daisuke Inoue
Guest Editor
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Keywords
- nose-to-brain drug delivery
- brain drug delivery system
- CNS diseases
- intranasal administration
- nasal formulation
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