TRP Channels in Physiology and Pathophysiology—3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 78
Special Issue Editors
Interests: physiology; aqueous humor physiology; lens physiology; pharmacology; signal transduction; cell biology
Special Issues, Collections and Topics in MDPI journals
Interests: ocular tissues; ion channels; transporters; lens; lens transparency; lens cataract
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous successful Special Issue “TRP Channels in Physiology and Pathophysiology 2.0"（https://www.mdpi.com/journal/ijms/special_issues/Z79IQ42897).
As many as thirty TRP channels have been identified with wide distribution and conservation in most organisms, tissues, and cell types. As they are polymodal, TRP channels are activated and regulated by multiple stimuli including chemical ligands (endogenous and exogenous), heat, cold, mechanical stress, osmotic pressure, vibration, pH, and electrical stimulation. TRPs are cation channels which, depending on their differential permeability to Ca2+, can influence numerous downstream signaling pathways that in turn regulate cellular functions that are as diverse as ion transport and homeostasis, fluid secretion, inflammation, pressure and thermoregulation, vision, taste, sense, and smell. Functional TRP channels have been expressed in almost all tissues of the body. Thus, the malfunction, mutation, and over/underexpression of TRPs play roles in many diseases. Based on this emerging body of work on TRP channels, our aim is to publish a Special Issue of IJMS with research and review articles describing current knowledge and data on the sensing, mechanistics, and functional and pathophysiological roles of TRP channels in tissues. We are seeking articles that explore the roles played by TRP channels at molecular, biochemical, physiological, pharmacological, and genetic levels and how they impact the development, normal structure and function, and pathology of all tissues.
Dr. Mohammad Shahidullah
Prof. Dr. Paul James Donaldson
Guest Editors
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Keywords
- transient receptor potential (TRP) channels
- retina
- lens
- lens epithelium
- ion transport
- homeostasis
- ciliary body
- ciliary epithelium
- aqueous humor
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