JAK/STAT Pathway in Stem Cell Biology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 37
Special Issue Editor
Special Issue Information
Dear Colleagues,
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway is a critically conserved mechanism that governs fundamental cellular processes, including proliferation, differentiation, and survival. In the dynamic field of stem cell biology, this pathway is a pivotal regulator of self-renewal, lineage commitment, and plasticity in both embryonic and adult stem cells. Dysregulation of JAK/STAT signaling is further implicated in various pathologies, from developmental disorders to cancer, often through its effects on stem cell populations.
This Special Issue aims to compile cutting-edge original research and comprehensive review articles that explore the multifaceted roles of the JAK/STAT pathway in stem cell biology. We welcome contributions that investigate mechanistic insights, novel regulatory components, crosstalk with other signaling networks, and translational applications. Topics of interest include, but are not limited to, the pathway's role in pluripotency, tissue regeneration, disease modeling, and the development of targeted therapeutic strategies. By highlighting recent advances, this collection will provide a valuable resource for researchers dedicated to understanding stem cell regulation and harnessing its potential for biomedical innovation.
Prof. Dr. Willis Li
Guest Editor
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Keywords
- JAK/STAT signaling
- stem cell self-renewal
- cellular differentiation
- pluripotency
- hematopoietic stem cells
- signal transduction
- cytokine receptors
- transcriptional regulation
- stem cell niche
- regenerative medicine
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