Dear Colleagues,
Recent advances in high-throughput sequencing, genome editing, and integrative omics approaches have profoundly reshaped our understanding of molecular genetics and genomics. This Topical Collection aims to assemble high-quality review articles that offer critical, up-to-date syntheses of progress across diverse fields within molecular genetics and genomics. The objective is to provide a curated platform for authoritative discussions on emerging trends, technological innovations, and conceptual breakthroughs.
This collection welcomes contributions that span basic molecular mechanisms to translational applications, with a focus on areas in which genetics and genomics intersect with medicine, biotechnology, evolution, and forensic science. We are particularly interested in reviews that not only summarize current knowledge, but also propose future directions and identify unanswered questions.
We encourage the Editorial Board Members of the Molecular Genetics and Genomics Section of the International Journal of Molecular Sciences to contribute review articles that reflect recent advances in their respective areas of expertise. Editorial Board Members are also welcome to invite qualified colleagues and leading experts in the field to submit contributions.
We also welcome the submission of articles from the broader scientific community, as well as those with recognized expertise in molecular genetics and genomics.
The scope of this Special Issue includes, but is not limited to, the following topics:
- Gene regulation and chromatin architecture: transcriptional control, enhancer-promoter communication, 3D genome organisation, and noncoding RNAs
- Epigenetics and epitranscriptomics: heritable regulation of gene expression, RNA modifications, and their role in development and disease
- Functional and comparative genomics: gene function annotation, pathway analysis, and comparative studies across species
- Single-cell and spatial omics: applications in developmental biology, cancer, and tissue heterogeneity
- Genome editing and synthetic biology: CRISPR-based technologies, base editing, gene drives, and synthetic genome design
- Genomic medicine and diagnostics: rare genetic disorders, cancer genomics, pharmacogenomics, and precision medicine strategies
- Population genomics and human evolution: demographic inference, adaptation, ancient DNA, and evolutionary constraints
- Systems biology and integrative multi-omics: transcriptomics, proteomics, metabolomics, and integrated pathway and network analysis
- Long-read sequencing and structural variation: emerging methods for characterising complex genomic regions
- Forensic genetics and genomics: advanced DNA typing, ancestry inference, molecular phenotyping, and challenges in interpretation and ethics
- Ethical, legal and social implications (ELSI): of emerging genetic and genomic technologies, particularly their impact on healthcare, identity, and society
This Topical Collection aims to serve as a dynamic reference for molecular biologists, geneticists, clinical researchers, and students, promoting critical reflection and guiding future research in molecular genetics and genomics.
Prof. Dr. Salvatore Saccone
Collection Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript.
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open access journal. For details about the APC please see here.
Submitted papers should be well formatted and use good English. Authors may use MDPI's
English editing service prior to publication or during author revisions.
