Molecular Advances in Human and Animal Disorder: Zebrafish as Model
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 72
Special Issue Editor
Interests: zebrafish; genes; neuroanatomy; sensory organs; veterinary sciences
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Zebrafish (Danio rerio) has become a pivotal model organism for studying molecular mechanisms underlying human and animal diseases due to their genetic similarity to humans, transparency during early development, and rapid life cycle. Advances in genetic engineering have enabled the precise manipulation of zebrafish genomes, facilitating the creation of disease models that mimic human genetic disorders. These models have provided profound insights into the pathophysiology of diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders. One of the key advantages of using zebrafish is their transparent embryos, which allow the real-time observation of developmental processes and disease progression at a cellular level. Researchers can study the effects of genetic mutations, drug responses, and cellular interactions in a living organism, offering a dynamic view of disease mechanisms. Additionally, zebrafish are highly amenable to high-throughput screening, making them ideal for large-scale drug discovery and toxicity testing. Recent breakthroughs include identifying genetic pathways involved in heart regeneration, understanding the molecular basis of muscle degeneration in muscular dystrophies, and elucidating the role of specific genes in brain development and function. These findings enhance our understanding of fundamental biological processes and pave the way for novel therapeutic strategies to treat various human and animal diseases.
Dr. Maria Cristina Guerrera
Guest Editor
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Keywords
- zebrafish model
- molecular advances
- human disorders
- animal disorders
- drug discovery
- disease research
- gene expression
- biomedical research
- developmental biology
- translational medicine
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