Tau Proteins
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 214
Special Issue Editor
Special Issue Information
Dear Colleagues,
Tau is predominantly a cytoplasmic protein in the neurons that stabilizes microtubules. Tau protein is also involved in other physiological functions such as regulation of axonal transport, neural polarization, synaptic function, and neuronal signaling as well as DNA protection. Hyperphosphorylated tau causes the formation of neurofibrillary tangles, the hallmark brain pathology of several neurodegenerative diseases known as tauopathies. Beyond its role in tauopathies, tau may also play a role in the regulation of neuronal hyperexcitability, pathogenesis of Parkinson’s disease. Recent discovery also demonstrated that tau plays important pathophysiological mechanistic roles in traumatic brain injury and heart failure. Therefore, the aims of this special issue are to focus on the roles of tau protein in different diseases beside tauopathies.
Dr. Chunling Dai
Guest Editor
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Keywords
- Tau protein
- Tauopathies
- traumatic brain injury
- heart failure
- immunotherapy
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