Pathogenetic Mechanisms, Advanced Imaging Techniques, and Treatment Innovations in Axial Spondyloarthritis and Psoriatic Arthritis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 January 2025 | Viewed by 97
Special Issue Editor
Interests: adaptive and innate immunity; spondyloarthritis; precision medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Axial Spondyloarthritis (axSpA) and Psoriatic Arthritis (PsA) are chronic inflammatory diseases characterized by distinct pathogenetic mechanisms and clinical manifestations. Recent advancements in molecular biology have provided insights into the genetic and immunological underpinnings of these conditions, highlighting the role of cytokines, such as TNF-α, IL-17, and IL-23, and the involvement of specific genetic markers such as HLA-B27 in axSpA.
This special issue is based on exploring the comprehensive pathogenetic mechanisms, advanced imaging techniques, and innovative treatment strategies for axSpA and PsA. The primary aim is to consolidate current research and clinical findings to enhance understanding and management of these diseases. Topics of interest include the molecular and genetic basis of axSpA and PsA, the development and application of novel imaging modalities, and the evaluation of emerging therapeutic approaches.
Innovative imaging techniques have significantly enhanced the diagnosis and monitoring of axSpA and PsA. Advanced modalities, including high-resolution MRI and ultrasonography, allow for early detection of structural changes and inflammation in the spine and peripheral joints, leading to improved disease management and patient outcomes. These techniques are complemented by novel biomarkers that facilitate accurate disease activity assessment and prognosis.
In terms of treatment, the therapeutic landscape for axSpA and PsA has evolved with the advent of biologics and small molecule inhibitors targeting specific immune pathways. TNF inhibitors, IL-17 inhibitors, and JAK inhibitors have shown substantial efficacy in reducing disease activity and preventing progression. Ongoing research into personalized medicine approaches promises to further refine treatment strategies, ensuring optimal patient-specific care.
The aim of this special issue is to integrate molecular insights, cutting-edge imaging, and tailored therapies, marking a new era in the management of these debilitating conditions and offering hope for improved patient quality of life and long-term outcomes.
Dr. Giuseppe Lopalco
Guest Editor
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Keywords
- pathogenesis
- small molecule inhibitors
- treatment innovations
- Axial Spondyloarthritis (axSpA)
- Psoriatic Arthritis (PsA)
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