Genetic Prediction of Risk of Common Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 30 March 2025 | Viewed by 16
Special Issue Editor
Interests: type 1 diabetes; immune tolerance; monoclonal antibodies; asthma; obesity; demyelinating diseases; cardiovascular disease; malaria
Special Issue Information
Dear Colleagues,
Common diseases, such as cancer, heart disease, diabetes, and dementia, affect millions of people and impose billions of dollars in costs on national health care budgets. These diseases have a complex genetic basis, and now hundreds of genetic variants have been identified that interact with each other and environmental factors to mediate susceptibility. However, the individual impact of these variants on disease risk is too low to be clinically useful. Polygenic risk scores and similar approaches have been employed to combine variants with the aim of developing more useful predictive tests. This Special Issue publishes reports of the latest advances in complex genetic analyses to define genetic signatures that can identify individuals at a higher or lower risk of suffering these diseases.
Dr. Grant Morahan
Guest Editor
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Keywords
- complex genetic diseases
- cancer
- heart disease
- diabetes
- dementia
- polygenic risk score
- genetic risk signatures
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