Omega-6 and Omega-3 Fatty Acid Imbalance: Roles in Human Health and Pathogenesis of Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 20 March 2026 | Viewed by 61
Special Issue Editor
2. Omega-3 and Global Health Institute, Boston, MA 02129, USA
Interests: omega-3; omega-6/omega-3 ratio; nutrigenomics; nutri-biotechnology; cancer metabolism; lipidomics; gut microbiota; nutritional interventions; inflammation; metabolic syndrome; chronic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The balance between omega-6 and omega-3 polyunsaturated fatty acids is a critical determinant of human health. Modern diets, however, are characterized by an excessive intake of omega-6 and insufficient omega-3, leading to a high omega-6/omega-3 ratio that has been implicated in the pathogenesis of many chronic diseases, including cardiovascular disorders, cancer, metabolic syndrome, autoimmune conditions, and neurodegenerative diseases. This Special Issue will provide a comprehensive platform for original research and reviews elucidating the molecular mechanisms, pathophysiological consequences, and therapeutic implications of fatty acid imbalance. We welcome contributions spanning basic science, clinical studies, nutritional interventions, and translational applications. By integrating multidisciplinary perspectives, this Special Issue will advance our understanding of how restoring a healthy omega-6/omega-3 balance can contribute to disease prevention and health promotion worldwide.
Dr. Jing X. Kang
Guest Editor
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Keywords
- omega-6/omega-3 ratio
- omega-6 fatty acids
- omega-3 fatty acids
- omega-6/omega-3 imbalance
- lipid metabolism
- inflammation
- chronic diseases
- cardiovascular disease
- cancer
- metabolic syndrome
- neurodegenerative diseases
- autoimmune diseases
- nutritional interventions
- polyunsaturated fatty acids (PUFAs)
- molecular mechanisms
- disease pathogenesis
- disease management
- health promotion
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