Progress in Fighting Inflammation to Reduce Life-Threatening Organ Dysfunction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 December 2024 | Viewed by 66
Special Issue Editor
Interests: inflammation; redox disorder; heart diseases; arrhythmia substrate; cardiac connexin-43; Cx-hemichannels; antiarrhythmic mechanisms of tested agents; omega-3 fatty acids; melatonin
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Damage in the heart, kidney, liver, and blood vessels is a pathological feature of cardiovascular and metabolic diseases or even air pollution, and hygrothermal stress is responsible for significant morbidity and mortality due to organ dysfunction. Current strategies focus mainly on the attenuation of risk factors, such as high blood pressure, blood glucose elevation, and dyslipidaemia, largely without targeting underlying mechanisms, namely inflammation, which contribute significantly to end-organ injury and failure. Furthermore, systemic inflammatory disorders, such as rheumatoid arthritis and bowel disease, jeopardise cardiovascular health. Inflammation accompanied with disorders of redox status and oxidative stress contribute significantly to pathomechanisms aggravating inflammation. Thus, fighting the deleterious inflammation burden is still an area of interest for translational research aimed at achieving efficient anti-inflammatory therapy.
Accordingly, the intention of this Special Issue of IJMS focuses on inflammasomopathy, associated largely with the pro-inflammatory NLRP3 (nod-like receptor protein 3 inflammasome), signalling along the implication of membrane-bound connexin43 hemichannels in systemic low-grade, acute, and chronic inflammation. The NLRP3 is presently the best characterized inflammasome. Furthermore, the discovery of other adverse unknown factors that aggravate inflammatory injury may be relevant. Using biomarkers of inflammation may refine phenotypic screening, improve risk stratification, and guide treatment eligibility in disease prevention.
Extensive attention focuses on the suppression or regulation of pro-inflammatory factors and signalling, e.g., via treatment with non-steroidal anti-inflammatory drugs, via pleiotropic anti-inflammatory effects of clinical drugs, via anti-inflammatory action of plant extracts, via endogenous compounds such as melatonin or omega-3 fatty acids, and even via a healthy lifestyle.
Dr. Narcis Tribulova
Guest Editor
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Keywords
- inflammasomopathy
- NLRP3
- nod-like receptor protein 3 inflammasome
- anti-inflammatory
- organ dysfunction
- organ injury
- organ failure
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