Recent Advances in Molecular Mechanisms Underlying Kidney Diseases: Pathophysiology and Therapeutic Targets, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 25 November 2024 | Viewed by 250
Special Issue Editor
Interests: kidney diseases; pharmacotherapy; kidney transplantation; cellular and molecular mechanisms; renal protection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Kidney diseases remain a major public health concern associated with the increasing morbidity and mortality of millions of people globally. Unfortunately, the prevalence of kidney diseases has increased significantly in recent times. The hallmarks of this important human pathology include the excessive accumulation and deposition of extracellular matrix, mesangiolysis, glomerular basement membrane thickening, tubulointerstitial fibrosis and many more, which eventually lead to loss of kidney function. As the pathogenesis of different forms of kidney diseases is multifactorial, several experimental models have recently been developed to mimic clinical situations and provide a mechanistic understanding of the various pathologies of kidney diseases, with the ultimate goal of identifying and developing potential therapeutic targets. These experimental models have identified several molecular mechanisms underlying various forms of kidney diseases. These mechanisms include:
- PI3K/Akt/mTOR pathway;
- Jak/Stat and inflammatory signaling pathways;
- Induction of oxidative stress and apoptotic pathways;
- Upregulation of renal transforming growth factor beta-1 expression;
- Activation of fibroblast and renin-angiotensin-aldosterone system;
- Mitochondrial dysfunction and depletion of adenosine triphosphate.
Targeting various molecular mechanisms underlying the pathophysiology of the different forms of kidney diseases has shown to be beneficial, and offers a huge potential to be explored that is amenable to novel therapies. This Special Issue focuses on recent research developments in the pathophysiology of kidney diseases and their therapeutic targets for diagnosis and treatment.
Original papers, review articles, and perspectives from experts in the field are welcome.
Dr. George J. Dugbartey
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- kidney diseases
- pathophysiology
- molecular mechanisms
- therapeutic targets
- acute kidney injury
- chronic kidney disease
- polycystic kidney disease
- end-stage renal disease
- IgA nephropathy
- diabetic nephropathy
- hypertensive nephropathy
- renal cancer
- kidney infarction
- kidney infection
- kidney failure
- kidney stones
- renal tubular acidosis
- renal artery stenosis
- acute tubular necrosis
- glomerulopathy
- interstitial nephritis
- nephrotic syndrome
- simple kidney cyst
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
