Update on Molecular Biology and Clinic in Huntington's Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 155
Special Issue Editors
Interests: neurodegenerative disorders; rare diseases; neuroimaging
Special Issue Information
Dear Colleagues,
Huntington’s disease was described by George Huntington over 150 years ago, and the causative gene mutation of the disease was identified over 30 years ago, but there remains a significant open area for exploration in genetics and clinic. Filling this research gap will improve both symptom- and disease-modifying treatments. The past 30 years of intensive research, since the discovery of the HD gene, have brought a substantial insight into the molecular pathophysiology of this disease. This progress allowed for preclinical studies and clinical trials aiming to determine the plethora of mechanisms leading to neurodegeneration to begin. Using different strategies to lower huntingtin , correcting brain cholesterol metabolism, and Sigma-1 receptor signaling are only a few examples of promising approaches that can help us develop effective disease-modifying therapy.
This Special Issue of the with special attention to its pathophysiology. We welcome both original research articles and review papers that reflect neurodegenerative processes.
Dr. Grzegorz Witkowski
Dr. Daniel Zielonka
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Huntington’s disease
- mutant huntingtin
- gene silencing
- mitochondrial dysfunction
- excitotoxicity
- animal models
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.