Molecular Insights into the Precision Medicine on Neoplastic Diseases: Challenges, Perspectives and Opportunities
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 201
Special Issue Editor
Interests: cancer biomarkers; pathology; atherosclerosis; biotechnology; histopathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nowadays, multidisciplinary approaches are considered the best treatments for many diseases, including neoplastic pathologies. Thanks to major advances in molecular biology, biotechnology, genetics, and informatics, and with the onset of the omics sciences, a global view of disease that considers the characteristics of both the pathology and the patient has become possible and necessary.
Although precision medicine is very promising, there are still many barriers that hinder the acquisition of new insights. Indeed, pathological mechanisms are the result of several interconnected factors that contribute to the pathogenesis and evolution of a disease. This complexity results in the identification of a specific target that represents only a small piece of a wider mosaic. Moreover, in many diseases, after an initial therapeutic response, patients start to develop resistance to treatment due to the ability of tumor cells to activate new pathways able to escape drugs and uncontrollably proliferate. In quite a few cases, instead, what were considered promising and effective treatments during experimental phases show little or no benefit to patients.
Starting from the idea that the genome of each person, interacting with the environment, acquires unique characteristics, the paradigm has started to change: it is possible to conceive a comprehensive treatment that considers different information about the single patient. Thus, pathologies are not more comparable between different people and can be more efficiently and effectively diagnosed and treated with a one-to-one approach.
There are many expectations, and there is a high potential for precision medicine in the treatment of many diseases. For this reason, the entire scientific community is invited to expand and share knowledge in this field in order to contribute a thorough diagnosis, treatments, and monitoring of cancer disease.
New advances on molecular mechanisms or pathophysiology are welcome, whereas descriptive or phenomenological studies, as well as papers containing only clinical trials/data, do not fall within the scope of IJMS and cannot be accepted.
Potential topics include, but are not limited to, the following:
- The new paradigm of precision medicine in oncological field: pros and cons.
- New potential targets for precision medicine in cancer.
- New advances and methodologies for the development of personalized medicine approaches for neoplastic diseases.
- Precision medicine and its application in oncology.
Dr. Manuela Montanaro
Guest Editor
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Keywords
- cancer
- molecular biology
- precision medicine
- targeted therapy
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