Future Directions for Mesenchymal Stromal Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 25
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mesenchymal stromal cells (MSCs) derived from both perinatal and adult tissues have been tested in over one thousand clinical trials; however, in many pathologies, MSCs have only shown modest efficacy. In regenerative medicine, MSCs have significant advantages over other cell types, including their ease of isolation and expansion and tolerability under allogeneic use. The key challenges faced in MSC-based therapies include our incomplete understanding of their mechanism of action, the insufficient secretion of therapeutically relevant factors, poor cell retention, and inadequate delivery. For this Special Issue, we invite submissions of articles exploring the future of MSCs, including their use in modelling diseases and the isolation of MSC-derived factors such as extracellular vesicles, as well as modifications to the cells to increase their efficacy with minimal impact on their positive safety profile.
Dr. Fernando A. Fierro
Guest Editor
Manuscript Submission Information
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Keywords
- mesenchymal stromal cells
- MSC-derived factors
- MSC-based therapies
- extracellular vesicles
