Advances in Antibody–Drug Conjugates
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 72
Special Issue Editor
Interests: T helper cell differentiation; autoimmune diseases; antibody engineering and antibody drug conjugate; Th2/ILC2; asthma; liver fibrosis
Special Issue Information
Dear Colleagues,
Antibody–drug conjugates (ADCs) represent a significant advance in cancer treatment by combining the specificity of antibodies with the potency of highly cytotoxic agents. This targeted strategy has the potential to reduce the severity of side effects by preferentially delivering the therapeutic payload directly to the tumor site, with ADCs sometimes referred to as ‘precision chemotherapy’. As our understanding of tumor biology deepens and ADC design improves, we are moving closer to effective, safe, and personalized cancer therapies. Numerous innovative ADC formats are being developed, including bispecific ADCs, dual-drug ADCs, conditionally active ADCs, immunostimulatory ADCs, and antibody–siRNA conjugates. Each of these formats offers unique capabilities to tackle a range of cancer treatment challenges, bringing new hope to patients with difficult-to-treat cancers.
Antibody–drug conjugates have been developed primarily for the treatment of cancer. However, the development of ADCs for non-oncology indications is still in its early stages. As we continue to improve our understanding of disease pathogenesis and identify more disease-related surface-specific markers, as well as potent small molecules that target the critical molecular pathways relevant to different diseases, the potential applications of ADCs may expand to a wide range of diseases beyond cancer.
This Special Issue will cover all aspects of the roles and mechanisms of ADC therapeutics in cancer and non-oncology indications, focusing on recent advances in the ADC platform and technology, including targets, antibody selection, payload, and linker and conjugation chemistry. Both original research and review articles are welcome.
Prof. Dr. Bing Sun
Guest Editor
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Keywords
- antibody–drug conjugate (ADC)
- cancer treatment
- non-oncology indications
- antibody selection
- payload
- linker
- conjugation chemistry
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